INT37103

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Context Info
Confidence 0.67
First Reported 1987
Last Reported 2010
Negated 3
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.32
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHRNE) transport (CHRNE) plasma membrane (CHRNE)
Anatomy Link Frequency
juvenile 1
CHRNE (Homo sapiens)
Pain Link Frequency Relevance Heat
Action potential 16 95.80 Very High Very High Very High
Pain 2 73.36 Quite High
anesthesia 4 48.56 Quite Low
rheumatoid arthritis 2 42.32 Quite Low
Inflammation 10 40.24 Quite Low
corticosteroid 46 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
abdominal pain 6 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
medulla 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 354 99.34 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 24 99.04 Very High Very High Very High
Muscle Hypotonia 2 97.64 Very High Very High Very High
Congenital Myasthenic Syndromes 50 96.60 Very High Very High Very High
Disease 38 95.24 Very High Very High Very High
Lower Respiratory Tract Infection 4 93.68 High High
Patent Ductus Arteriosus 2 87.44 High High
Autoimmune Disease 10 87.12 High High
Scoliosis 2 86.80 High High
Cyanosis 2 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the total yield of positive serological results was significantly improved (90%) by assaying AChR modulating antibodies when AChR binding antibodies were not detected, because in 27 patients (8%) only one of the two tests was positive.
Neg (not) Gene_expression (detected) of AChR
1) Confidence 0.67 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.34 Pain Relevance 0
However, the total yield of positive serological results was significantly improved (90%) by assaying AChR modulating antibodies when AChR binding antibodies were not detected, because in 27 patients (8%) only one of the two tests was positive.
Neg (not) Gene_expression (detected) of AChR
2) Confidence 0.58 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.35 Pain Relevance 0
It may be difficult to make the distinction between juvenile MG and congenital MG, particularly in the absence of AChR or MuSK antibodies, or a clear history of ptosis and other manifestations of hypotonia from the time of birth that would suggest genetic disease.
Gene_expression (antibodies) of AChR in juvenile associated with muscle hypotonia, myasthenia gravis, ocular toxicity (including many sub-types) and disease
3) Confidence 0.43 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.78 Pain Relevance 0.07
AChR antibodies
Gene_expression (antibodies) of AChR
4) Confidence 0.37 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 0.74 Pain Relevance 0
Serum antibodies against AChR and MuSK were negative.
Neg (negative) Gene_expression (negative) of AChR
5) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.73 Pain Relevance 0.05
These mutations impair the expression and stability of MuSK, diminish agrin-dependent MuSK phosphorylation and AChR clustering, and fail to co-immunoprecipitate with Dok-7 but not with Lrp4 or Tid1.
Gene_expression (expression) of AChR
6) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2876883 Disease Relevance 0.39 Pain Relevance 0

General Comments

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