INT37104

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Context Info
Confidence 0.27
First Reported 1987
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 1.76
Pain Relevance 1.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (GANAB) Golgi apparatus (GANAB) endoplasmic reticulum (GANAB)
carbohydrate metabolic process (GANAB)
GANAB (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 18 100.00 Very High Very High Very High
diclofenac 3 87.52 High High
anesthesia 1 48.96 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 6 100.00 Very High Very High Very High
Myasthenia Gravis 6 97.60 Very High Very High Very High
Colon Cancer 9 96.64 Very High Very High Very High
Muscle Weakness 2 71.44 Quite High
Thymoma 1 65.28 Quite High
Neurological Disease 1 63.20 Quite High
Motor Neuron Diseases 3 60.40 Quite High
Syndrome 1 56.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that inhibition of long chain fatty acid oxidation via binding of NSAIDs to the alpha-subunit of the trifunctional protein may contribute to the inhibitory effects of NSAIDs on colorectal carcinoma cell growth.
alpha-subunit Binding (binding) of associated with colon cancer and cinod
1) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694975 Disease Relevance 0.40 Pain Relevance 0.57
We now report that all NSAIDs tested bound to the alpha-subunit of the trifunctional protein of the long chain fatty acid oxidation pathway, as assessed by competition with 125I-[Nle15]-gastrin2,17 in a covalent cross-linking assay.
alpha-subunit Binding (bound) of associated with cinod
2) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9694975 Disease Relevance 0.33 Pain Relevance 0.45
Binding of nonsteroidal antiinflammatory drugs to the alpha-subunit of the trifunctional protein of long chain fatty acid oxidation.
alpha-subunit Binding (Binding) of associated with inflammation
3) Confidence 0.27 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 9694975 Disease Relevance 0.36 Pain Relevance 0.49
One would anticipate that antibodies with greatest pathophysiological potential would be of an IgG with greatest pathophysiological potential would be of an IgG subclass that activates complement, or of a specificity that competes for acetylcholine's binding site on the receptor or readily cross-links two AChR molecules to trigger receptor modulation (e.g., by binding to sites on the duplicated alpha-subunit).
alpha-subunit Binding (binding) of
4) Confidence 0.04 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.67 Pain Relevance 0

General Comments

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