INT37105

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Context Info
Confidence 0.31
First Reported 1987
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 6.88
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHRNE) transport (CHRNE) plasma membrane (CHRNE)
CHRNE (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 2 98.76 Very High Very High Very High
fluoxetine 5 97.94 Very High Very High Very High
rheumatoid arthritis 5 95.32 Very High Very High Very High
Inflammation 25 94.28 High High
depression 3 90.16 High High
tolerance 15 59.60 Quite High
anesthesia 1 51.84 Quite High
sSRI 1 48.24 Quite Low
Action potential 35 27.00 Quite Low
corticosteroid 115 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 846 99.96 Very High Very High Very High
Autoimmune Disease 25 97.64 Very High Very High Very High
Systemic Lupus Erythematosus 5 96.52 Very High Very High Very High
Neuroblastoma 2 96.32 Very High Very High Very High
Rheumatoid Arthritis 5 95.32 Very High Very High Very High
INFLAMMATION 15 94.28 High High
Neuropathic Pain 20 93.76 High High
Depression 3 90.16 High High
Obsessive-compulsive Disorder 1 88.84 High High
Motor Neuron Diseases 18 82.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
One would anticipate that antibodies with greatest pathophysiological potential would be of an IgG with greatest pathophysiological potential would be of an IgG subclass that activates complement, or of a specificity that competes for acetylcholine's binding site on the receptor or readily cross-links two AChR molecules to trigger receptor modulation (e.g., by binding to sites on the duplicated alpha-subunit).
AChR Binding (cross-links) of
1) Confidence 0.31 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.69 Pain Relevance 0.05
In SP MG, binding of antibody to the AChR initiates autoimmune attack on the endplate region.
AChR Binding (binding) of associated with myasthenia gravis
2) Confidence 0.31 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 0.75 Pain Relevance 0.06
Rarely, false positive results in AChR binding antibody assays have been observed in patients with other autoimmune diseases such as systemic lupus erythematosus, rheumatoid arthritis, and inflammatory neuropathy.
AChR Binding (binding) of associated with autoimmune disease, inflammation, neuropathic pain, rheumatoid arthritis and systemic lupus erythematosus
3) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.50 Pain Relevance 0.09
Approximately 4% of patients with negative AChR binding antibodies have an elevated AChR modulating antibody assay, and approximately 1% of patients with negative AChR binding antibodies demonstrate increased AChR blocking antibodies [29].


AChR Binding (binding) of
4) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.09 Pain Relevance 0.06
Though relatively less sensitive than SFEMG, AChR binding antibodies are highly specific for autoimmune MG.
AChR Binding (binding) of associated with myasthenia gravis
5) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.43 Pain Relevance 0.08
Approximately 4% of patients with negative AChR binding antibodies have an elevated AChR modulating antibody assay, and approximately 1% of patients with negative AChR binding antibodies demonstrate increased AChR blocking antibodies [29].


AChR Binding (binding) of
6) Confidence 0.24 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.08 Pain Relevance 0.06
The current study aimed to investigate the possible modulatory role of mI versus fluoxetine or imipramine pretreatments on serotonin-2A receptor (5HT2A-R) and muscarinic acetylcholine receptor (mAChR) function and binding in in vitro systems.
mAChR Binding (binding) of associated with serotonin and fluoxetine
7) Confidence 0.04 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214506 Disease Relevance 0.35 Pain Relevance 0.46

General Comments

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