INT37107

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Context Info
Confidence 0.43
First Reported 1987
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.25
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHRNE) transport (CHRNE) plasma membrane (CHRNE)
Anatomy Link Frequency
muscle 2
CHRNE (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 5 99.56 Very High Very High Very High
anesthesia 3 99.50 Very High Very High Very High
sSRI 1 96.12 Very High Very High Very High
depression 3 82.08 Quite High
Serotonin 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Muscle Weakness 6 99.08 Very High Very High Very High
Syndrome 3 88.56 High High
Motor Neuron Diseases 9 87.52 High High
Myasthenia Gravis 18 83.76 Quite High
Neurological Disease 3 76.24 Quite High
Neuroblastoma 2 75.00 Quite High
Thymoma 3 70.96 Quite High
Depression 3 57.80 Quite High
Obsessive-compulsive Disorder 1 56.48 Quite High
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The immunoprecipitation test for AChR blocking antibodies yielded fewer positive results (52%), but there was a significant correlation between the degree of AChR blockade and generalization of muscle weakness.
Negative_regulation (blockade) of AChR in muscle associated with muscle weakness
1) Confidence 0.43 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.45 Pain Relevance 0.07
False positive results were rare and were attributed to unexplained antibodies to 125I-alpha-Bgt (AChR binding antibody assay) and recent general anesthesia using muscle relaxants (AChR blocking and AChR modulating antibody assays).
Negative_regulation (blocking) of AChR in muscle associated with anesthesia
2) Confidence 0.42 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.91 Pain Relevance 0.10
In no patient was this the only positive test, because the test for AChR modulating antibodies in this study detected both AChR blocking and modulating antibodies.
Negative_regulation (detected) of AChR
3) Confidence 0.42 Published 1987 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 3479935 Disease Relevance 0.63 Pain Relevance 0.08
In addition mI, and at high concentrations fluoxetine and imipramine, also reduces mAChR function.
Negative_regulation (reduces) of mAChR associated with fluoxetine
4) Confidence 0.06 Published 2004 Journal Metab Brain Dis Section Abstract Doc Link 15214506 Disease Relevance 0.26 Pain Relevance 0.62

General Comments

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