INT37111

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Context Info
Confidence 0.44
First Reported 1983
Last Reported 2011
Negated 0
Speculated 5
Reported most in Abstract
Documents 7
Total Number 11
Disease Relevance 2.61
Pain Relevance 3.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
caudate nucleus 2
substantia nigra 2
fat 2
sympathetic nervous system 2
neural 2
Mme (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 12 99.80 Very High Very High Very High
antagonist 6 99.68 Very High Very High Very High
dopamine receptor 2 99.32 Very High Very High Very High
Enkephalin 16 98.80 Very High Very High Very High
Intracerebroventricular 2 98.60 Very High Very High Very High
agonist 13 98.20 Very High Very High Very High
Substantia nigra 5 97.08 Very High Very High Very High
Delta opioid receptors 1 91.80 High High
Opioid 1 87.24 High High
opiate 1 77.76 Quite High
Disease Link Frequency Relevance Heat
Arrhythmia Under Development 1 99.98 Very High Very High Very High
Weight Gain 18 99.80 Very High Very High Very High
Catalepsy 4 98.92 Very High Very High Very High
Myocardial Infarction 7 98.80 Very High Very High Very High
Obesity 76 95.12 Very High Very High Very High
Arrhythmogenic Right Ventricular Dysplasia 1 95.12 Very High Very High Very High
Natriuresis 12 83.00 Quite High
Stress 20 80.48 Quite High
Diabetes Mellitus 18 79.56 Quite High
Hypertension 1 72.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
[Anti-arrhythmia effects of enkephalinase inhibitors].
Regulation (effects) of Negative_regulation (inhibitors) of enkephalinase associated with arrhythmia under development
1) Confidence 0.44 Published 2001 Journal Eksp Klin Farmakol Section Title Doc Link 11764494 Disease Relevance 0.20 Pain Relevance 0.30
The present series of experiments examined the effects of thiorphan, an inhibitor of enkephalinase A, on cardiovascular responses to intracerebroventricular (i.c.v.) administration of [D-Ala2,Met5]enkephalin (DAME) and its amide and on peripheral interactions with the sympathetic nervous system and vasoactive peptides.
Spec (examined) Regulation (effects) of Negative_regulation (inhibitor) of enkephalinase in sympathetic nervous system associated with enkephalin and intracerebroventricular
2) Confidence 0.42 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6360696 Disease Relevance 0.07 Pain Relevance 0.41
[The effect of multiple administrations of beta-endorphin and an enkephalinase inhibitor into the rat caudate nucleus on the realization of an avoidance conditioned reflex].
Regulation (effect) of Negative_regulation (inhibitor) of enkephalinase in caudate nucleus
3) Confidence 0.42 Published 1995 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Title Doc Link 7754679 Disease Relevance 0 Pain Relevance 0.09
We examined the effects of ONO-9902, a novel NEP inhibitor, on changes in hemodynamic parameters, NEP activity and neurohumoral factors in rats with CHF induced by left coronary artery ligation (CAL).
Spec (examined) Regulation (effects) of Spec (examined) Negative_regulation (inhibitor) of NEP in left coronary artery associated with myocardial infarction
4) Confidence 0.35 Published 2001 Journal Cardiovasc. Res. Section Abstract Doc Link 11476752 Disease Relevance 0.61 Pain Relevance 0
In order to determine the role of ACE and NEP inhibition independently rats (Groups 5 and 6) were fed a high-fat diet containing Enalapril (500?
Spec (determine) Regulation (role) of Negative_regulation (inhibition) of NEP in fat
5) Confidence 0.26 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 0.30 Pain Relevance 0.06
Influence of enkephalinase inhibitor was the most effective.
Regulation (Influence) of Negative_regulation (inhibitor) of enkephalinase
6) Confidence 0.25 Published 1995 Journal Zh Vyssh Nerv Deiat Im I P Pavlova Section Abstract Doc Link 7754679 Disease Relevance 0 Pain Relevance 0.09
Since AVE7688 is an inhibitor of both angiotensin converting enzyme and neutral endopeptidase we also investigated the role of Enalapril, an inhibitor of angiotensin converting enzyme, and Candoxatril, an inhibitor of neutral endopeptidase, on weight gain and vascular and neural function in rats fed a high-fat diet.
Spec (investigated) Regulation (role) of Negative_regulation (inhibitor) of neutral endopeptidase in neural associated with weight gain
7) Confidence 0.22 Published 2011 Journal Journal of Obesity Section Body Doc Link PMC2933895 Disease Relevance 1.04 Pain Relevance 0.10
The effect of inhibitors of the membrane-bound metalloendopeptidase-24.11 ('enkephalinase') on the activity of electrophysiologically identifiable neurons in the substantia nigra is described.
Regulation (effect) of Negative_regulation (inhibitors) of enkephalinase in substantia nigra associated with substantia nigra
8) Confidence 0.18 Published 1987 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3480807 Disease Relevance 0 Pain Relevance 0.12
The effect of specific inhibitors of APM, ACE and NEP on the permeability of [Met5]enkephalin (Met-Enk) and a conformationally constrained and enzymatically stable analog, DPDPE, also was determined.
Spec (determined) Regulation (effect) of Negative_regulation (inhibitors) of NEP associated with enkephalin
9) Confidence 0.14 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7915319 Disease Relevance 0 Pain Relevance 0.35
Effects of SCH 32615, an enkephalinase inhibitor, on D-1 and D-2 dopamine receptor-mediated behaviors.
Regulation (Effects) of Negative_regulation (inhibitor) of enkephalinase associated with dopamine receptor
10) Confidence 0.09 Published 1995 Journal Neuropharmacology Section Title Doc Link 7566505 Disease Relevance 0.15 Pain Relevance 0.77
To test this hypothesis, the effects of SCH 32615, an enkephalinase inhibitor, on DA antagonist-induced catalepsy, DA D-1 agonist-induced non-stereotyped grooming, and DA D-2 agonist-induced stereotyped behavior were studied.
Regulation (effects) of Negative_regulation (inhibitor) of enkephalinase associated with dopamine, catalepsy, antagonist and agonist
11) Confidence 0.09 Published 1995 Journal Neuropharmacology Section Abstract Doc Link 7566505 Disease Relevance 0.18 Pain Relevance 0.83

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