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Context Info
Confidence 0.60
First Reported 1987
Last Reported 1998
Negated 1
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 3.65
Pain Relevance 1.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prtn3) peptidase activity (Prtn3) plasma membrane (Prtn3)
enzyme binding (Prtn3)
Anatomy Link Frequency
central nervous system 1
Prtn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 1 99.68 Very High Very High Very High
Neuritis 8 99.64 Very High Very High Very High
Multiple sclerosis 3 92.96 High High
Inflammation 4 85.64 High High
peripheral neuropathy 1 75.56 Quite High
Demyelination 2 75.00 Quite High
abdominal pain 1 72.76 Quite High
cva 2 68.64 Quite High
Arthritis 1 64.96 Quite High
corticosteroid 1 62.48 Quite High
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 4 99.64 Very High Very High Very High
Microscopic Polyangiitis 11 97.78 Very High Very High Very High
Vasculitis 8 96.96 Very High Very High Very High
Demyelinating Disease 8 94.20 High High
Systemic Vasculitis 2 90.80 High High
Renal Insufficiency 1 89.88 High High
Hepatitis B Virus Infection 2 88.36 High High
Hepatitis 1 87.84 High High
INFLAMMATION 4 85.64 High High
Hepatitis C Virus Infection 1 76.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Proteinase K and PMSF produced no significant change.
Neg (no) Gene_expression (produced) of Proteinase K
1) Confidence 0.60 Published 1987 Journal J. Neurol. Sci. Section Abstract Doc Link 3481630 Disease Relevance 0.63 Pain Relevance 0.41
Since calcium activated neutral proteinase (calpain) is present in the central nervous system (CNS) and degrades myelin proteins, this endopeptidase has been suggested to play a role in myelin destruction in demyelinating diseases such as multiple sclerosis (MS).
Gene_expression (present) of proteinase in central nervous system associated with multiple sclerosis, central nervous system and demyelinating disease
2) Confidence 0.04 Published 1998 Journal Brain Res. Section Abstract Doc Link 9518658 Disease Relevance 0.77 Pain Relevance 0.35
Antineutrophil cytoplasm antibodies (ANCA) are found in 75% of MPA patients and the majority of these ANCA detected are perinuclear-staining anti-myeloperoxidase ANCA, although anti-proteinase 3 has also be detected.
Gene_expression (detected) of anti-proteinase 3 associated with microscopic polyangiitis
3) Confidence 0.01 Published 1996 Journal Ann Med Interne (Paris) Section Abstract Doc Link 8796093 Disease Relevance 2.24 Pain Relevance 0.28

General Comments

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