INT37130

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Context Info
Confidence 0.41
First Reported 1986
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.81
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Umod) extracellular region (Umod) Golgi apparatus (Umod)
cytoplasmic membrane-bounded vesicle (Umod) plasma membrane (Umod)
Anatomy Link Frequency
midbrain 1
Umod (Rattus norvegicus)
Pain Link Frequency Relevance Heat
midbrain 6 100.00 Very High Very High Very High
qutenza 12 99.96 Very High Very High Very High
fluoxetine 11 99.70 Very High Very High Very High
gABA 5 96.96 Very High Very High Very High
Ventral tegmentum 7 93.36 High High
withdrawal 7 92.36 High High
Dismenorea 5 89.68 High High
Neurotransmitter 1 72.80 Quite High
interstitial cystitis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Lordosis 8 100.00 Very High Very High Very High
Hypothermia 2 98.00 Very High Very High Very High
Interstitial Cystitis 2 96.92 Very High Very High Very High
Convulsion 4 94.08 High High
Syndrome 1 90.68 High High
Reprotox - General 1 5 89.68 High High
Substance Withdrawal Syndrome 1 86.72 High High
Anxiety Disorder 2 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specifically, this effect was due to reduced levels of 3alpha,5alpha-THP which enhance transcription of the gene encoding the alpha4 subunit of the GABA(A) receptor.
Negative_regulation (levels) of THP associated with gaba
1) Confidence 0.41 Published 1998 Journal Nature Section Abstract Doc Link 9582073 Disease Relevance 1.04 Pain Relevance 0.91
Systemic acute or chronic fluoxetine significantly decreased lordosis and midbrain 3alpha,5alpha-THP levels compared to vehicle.
Negative_regulation (decreased) of THP in midbrain associated with midbrain, lordosis and fluoxetine
2) Confidence 0.41 Published 2003 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 14993038 Disease Relevance 0.49 Pain Relevance 1.17
Seven to 24 days after the capsaicin injection, Thp was still decreased in 4 surviving frogs (Thp = 15 +/- 2 degrees C).
Negative_regulation (decreased) of Thp associated with qutenza
3) Confidence 0.36 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3485298 Disease Relevance 0.10 Pain Relevance 0.44
After an intraperitoneal (IP) injection of 20 mg/kg of capsaicin, Thp was significantly decreased and equalled 3 +/- 1 degree C.
Negative_regulation (decreased) of Thp associated with qutenza
4) Confidence 0.36 Published 1986 Journal Physiol. Behav. Section Abstract Doc Link 3485298 Disease Relevance 0.09 Pain Relevance 0.39
PATIENTS, SUBJECTS AND METHODS: The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC.
Negative_regulation (reduced) of THP
5) Confidence 0.35 Published 2009 Journal BJU Int. Section Body Doc Link 19007360 Disease Relevance 0.10 Pain Relevance 0

General Comments

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