INT37148

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.43
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.91
Pain Relevance 4.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CALCA) aging (CALCA) extracellular region (CALCA)
nucleus (CALCA) intracellular (CALCA) cell-cell signaling (CALCA)
Anatomy Link Frequency
blood 2
CPA 2
neural 2
CALCA (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 49 100.00 Very High Very High Very High
calcitonin gene related peptide 16 100.00 Very High Very High Very High
Clonidine 9 100.00 Very High Very High Very High
substance P 27 99.80 Very High Very High Very High
adenocard 4 99.76 Very High Very High Very High
Neurotransmitter 1 99.36 Very High Very High Very High
tetrodotoxin 13 98.24 Very High Very High Very High
qutenza 22 97.96 Very High Very High Very High
antagonist 21 93.84 High High
c fibre 2 93.12 High High
Disease Link Frequency Relevance Heat
Heat Stress Disorders 11 99.70 Very High Very High Very High
Pressure And Volume Under Development 3 98.72 Very High Very High Very High
Thyroid Disease 1 91.92 High High
Coronary Artery Disease 2 89.52 High High
Ganglion Cysts 1 88.72 High High
INFLAMMATION 48 82.16 Quite High
Myocardial Infarction 2 80.72 Quite High
Clostridium Difficile Infection 1 56.88 Quite High
Ileitis 1 55.56 Quite High
Colitis 1 53.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In sucrose gap, brief superfusion with 0.3 microM CGRP produced a TTX (1 microM)- resistant membrane hyperpolarization and relaxation: the hyperpolarization produced by CGRP was inhibited by about 50% by either TEA (10 mM) or CPA (10 microM), while being unaffected by glibenclamide (3 microM).
Negative_regulation (inhibited) of Gene_expression (produced) of CGRP in CPA associated with tetrodotoxin and calcitonin gene-related peptide
1) Confidence 0.43 Published 1996 Journal Regul. Pept. Section Abstract Doc Link 8701024 Disease Relevance 0 Pain Relevance 1.10
L-NAME treatment could also inhibit clonidine-induced CGRP synthesis and secretion concomitantly with the decreased NO content in culture medium.
Negative_regulation (inhibit) of Gene_expression (synthesis) of CGRP associated with calcitonin gene-related peptide and clonidine
2) Confidence 0.42 Published 2009 Journal Peptides Section Abstract Doc Link 19520131 Disease Relevance 0 Pain Relevance 1.18
And heat stress increased the expression of CGRP, which was also abolished by capsazepine.
Negative_regulation (abolished) of Gene_expression (expression) of CGRP associated with heat stress disorders and calcitonin gene-related peptide
3) Confidence 0.42 Published 2007 Journal Vascul. Pharmacol. Section Abstract Doc Link 17140857 Disease Relevance 0.71 Pain Relevance 0.71
Furthermore, it has also been reported that capsaicin-treated pigs significantly increase mean arterial blood pressure compared with controls and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure.
Negative_regulation (decrease) of Gene_expression (synthesis) of CGRP in blood associated with pressure and volume under development, qutenza and calcitonin gene-related peptide
4) Confidence 0.42 Published 2009 Journal Int. J. Cardiol. Section Abstract Doc Link 18280595 Disease Relevance 0.68 Pain Relevance 0.83
Verapamil (10(-5) M) and adenosine (10(-4) M) reduced the positive inotropic effect of hCGRP at concentrations of 3 X 10(-9) and 3 X 10(-8) M, but not at that of 3 X 10(-7) M.
Negative_regulation (reduced) of Gene_expression (effect) of hCGRP associated with adenocard
5) Confidence 0.38 Published 1986 Journal Peptides Section Abstract Doc Link 3489930 Disease Relevance 0 Pain Relevance 0.20
Ouabain (5 X 10(-5) M) inhibited the effect of hCGRP in concentrations of 3 X 10(-7) and 3 X 10(-8) M, but not in that of 3 X 10(-9) M.
Negative_regulation (inhibited) of Gene_expression (effect) of hCGRP
6) Confidence 0.38 Published 1986 Journal Peptides Section Abstract Doc Link 3489930 Disease Relevance 0 Pain Relevance 0.21
Increased levels of neurotransmitters in both mucosa and supernatant imply de novo production of both CGRP and SP, requiring the presence of neural cell bodies in the sac.
Negative_regulation (imply) of Gene_expression (production) of CGRP in neural associated with calcitonin gene related peptide, neurotransmitter and substance p
7) Confidence 0.24 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.51 Pain Relevance 0.76

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox