INT37168

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Context Info
Confidence 0.67
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 22
Total Number 24
Disease Relevance 9.61
Pain Relevance 4.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (APCS) protein folding (APCS) extracellular space (APCS)
extracellular region (APCS) protein complex (APCS)
Anatomy Link Frequency
T cells 3
plasma 1
DCs 1
SVR 1
epithelium 1
APCS (Homo sapiens)
Pain Link Frequency Relevance Heat
nalbuphine 7 99.12 Very High Very High Very High
Dopamine 116 98.76 Very High Very High Very High
algil 6 98.04 Very High Very High Very High
tramadol 7 97.48 Very High Very High Very High
fibrosis 95 97.20 Very High Very High Very High
Inflammation 55 92.68 High High
Pain 13 91.72 High High
Clonidine 6 90.08 High High
depression 1 88.28 High High
anesthesia 20 87.92 High High
Disease Link Frequency Relevance Heat
Pancreatitis 112 100.00 Very High Very High Very High
Fibrosis 128 99.12 Very High Very High Very High
Disease 41 99.12 Very High Very High Very High
Pressure And Volume Under Development 4 96.88 Very High Very High Very High
Hypoxia 112 96.76 Very High Very High Very High
Mucositis 129 96.68 Very High Very High Very High
Critical Illness 14 95.20 Very High Very High Very High
Hypercapnia 2 95.04 Very High Very High Very High
Hepatomegaly 3 94.72 High High
Splenomegaly 1 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Decreasing arterial PCO2 to the awake value by controlled ventilation increased SVR (P less than 0.05), but the associated increased SAP and decreased Q70 did not reach statistical significance.
Positive_regulation (increased) of SAP in SVR
1) Confidence 0.67 Published 1987 Journal Anesth. Analg. Section Abstract Doc Link 3492156 Disease Relevance 0.09 Pain Relevance 0.31
Direct intracavernosal (i.c.) injection of 1-30 microg/kg vardenafil or sildenafil also caused dose-dependent increases in ICP:SAP in the absence of PNS.
Positive_regulation (increases) of SAP
2) Confidence 0.67 Published 2002 Journal J. Androl. Section Abstract Doc Link 12002434 Disease Relevance 0.27 Pain Relevance 0
I.v. administration of either PDE 5 inhibitor facilitated PNS-induced erection and increased ICP:SAP in a dose-dependent manner, reaching peak response at approximately 5 minutes.
Positive_regulation (increased) of SAP
3) Confidence 0.67 Published 2002 Journal J. Androl. Section Abstract Doc Link 12002434 Disease Relevance 0.23 Pain Relevance 0
We also found increases in SAP (10%, p = 0.02) and DAP (32%, p = 0.0001) at 5 min, along with an increase in HR (8%, p = 0.0163) at 60 min.
Positive_regulation (increases) of SAP
4) Confidence 0.67 Published 1995 Journal Rev Esp Anestesiol Reanim Section Abstract Doc Link 7481025 Disease Relevance 0.34 Pain Relevance 0.06
Dopamine induced a significant increase in HR, systolic, mean and diastolic SAP in anesthetized models without any statistically significant effect on HR and SAP in the conscious model.
Positive_regulation (increase) of SAP
5) Confidence 0.61 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
Maximum increases in HR (p < or = 0.005, all comparisons) and SAP (p < or = 0.02, all comparisons) occurred one minute after intubation.
Positive_regulation (increases) of SAP
6) Confidence 0.49 Published 2004 Journal Middle East J Anesthesiol Section Abstract Doc Link 15651510 Disease Relevance 0.14 Pain Relevance 2.01
The laboratory results showed ESR accelerated in 87%, ALT elevated in 21.5%, AST elevated in 21.9%, S. bilirubin elevated in 16.5%, gamma GT elevated in 80.6%, and SAP elevated in 76.4%.
Positive_regulation (elevated) of SAP
7) Confidence 0.45 Published 2001 Journal J Egypt Soc Parasitol Section Abstract Doc Link 11775099 Disease Relevance 1.29 Pain Relevance 0.29
Weakly acidic reflux could be a potential mechanism for cough in 24 patients (with either increased oesophageal volume exposure, increased number of weakly acidic reflux or +SAP for weakly acidic reflux).
Positive_regulation (increased) of SAP
8) Confidence 0.45 Published 2007 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 17311606 Disease Relevance 0.14 Pain Relevance 0
RESULTS: Remifentanil decreased heart rate (HR), systolic, mean and diastolic systemic arterial pressures (SAP) in anesthetized animals while conscious monkeys presented an increase in HR, systolic, mean and diastolic SAP, as seen in humans for the respective state of consciousness (conscious and anesthetized).
Positive_regulation (increase) of SAP in heart
9) Confidence 0.41 Published 2008 Journal J Pharmacol Toxicol Methods Section Body Doc Link 18583160 Disease Relevance 0 Pain Relevance 0
Anaesthesia and surgery did not affect SAP plasma levels while patients showed a major increase in CRP concentrations preceding the cytokine responses.
Positive_regulation (increase) of SAP in plasma
10) Confidence 0.37 Published 1998 Journal Acta Anaesthesiol Scand Section Body Doc Link 9527747 Disease Relevance 0.06 Pain Relevance 0
Hamsters were treated with SAP immediately after radiation (day 0) and given SAP either every 2 days from day 0 to 12 or daily from days 0 to 7.
Positive_regulation (given) of SAP
11) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.71 Pain Relevance 0.14
Hamsters were treated with SAP immediately after radiation (day 0) and given SAP either every 2 days from day 0 to 12 or daily from days 0 to 7.
Positive_regulation (treated) of SAP
12) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.70 Pain Relevance 0.14
Promedior are developing SAP for the treatment of fibrotic diseases.
Positive_regulation (developing) of SAP associated with fibrosis and disease
13) Confidence 0.27 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2905325 Disease Relevance 0.72 Pain Relevance 0.14
CONCLUSIONS: The risk factors were significantly different between initially diagnosed ACS and SAP.
Positive_regulation (diagnosed) of SAP
14) Confidence 0.21 Published 2010 Journal J Cardiol Section Body Doc Link 20350505 Disease Relevance 0.22 Pain Relevance 0
In rabbits an immediate activation of protein C (PC) is a specific characteristic of hemostatic activation in SAP [5].
Positive_regulation (activation) of SAP associated with pancreatitis
15) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 0.96 Pain Relevance 0.04
In contrast, the study revealed increases in serum total and conjugated bilirubin levels in SAP treated with APC compared to the placebo.


Positive_regulation (increases) of SAP associated with pancreatitis
16) Confidence 0.20 Published 2010 Journal Crit Care Section Body Doc Link PMC2945119 Disease Relevance 1.04 Pain Relevance 0.03
The first involves T-cell receptor triggering by donor antigen on the surface of DCs or other APCs (Bromley et al 2001).
Positive_regulation (triggering) of APCs in DCs
17) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.24 Pain Relevance 0.03
B7-H3 is a B7 homolog inducible in APCs, which binds a putative receptor on T-cells, resulting in increased T-cell proliferation.
Positive_regulation (inducible) of APCs in T-cell
18) Confidence 0.19 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721321 Disease Relevance 0.07 Pain Relevance 0
CONCLUSIONS: COX-2 expression is upregulated in the adenomatous epithelium of SAP and FAP, while the COX-1 isoform appears to be constitutively expressed at low levels in both neoplastic and non-neoplastic regions.
Positive_regulation (upregulated) of SAP in epithelium
19) Confidence 0.19 Published 2001 Journal Scand. J. Gastroenterol. Section Body Doc Link 11495083 Disease Relevance 0.11 Pain Relevance 0
The efficacy of cellular immune responses also appears to rely on strong antigen-induced priming of T cells by efficient targeting and activation of professional APCs [6], [56].
Positive_regulation (activation) of APCs in T cells
20) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877091 Disease Relevance 0.31 Pain Relevance 0

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