INT37171

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Context Info
Confidence 0.55
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.18
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SULT1A1) small molecule metabolic process (SULT1A1) cytoplasm (SULT1A1)
Anatomy Link Frequency
liver 2
SULT1A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 15 99.00 Very High Very High Very High
fluoxetine 1 94.24 High High
Paracetamol 8 87.28 High High
Bile 9 67.20 Quite High
agonist 13 21.48 Low Low
Kinase C 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Opioid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 2 93.12 High High
Van Bogaert's Disease 7 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Gallstones 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Insulin Resistance 1 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quercetin, a flavonoid present in edible fruit, vegetable and wine, was a potent inhibitor of human liver SULT1A1 and estrogen sulfotransferase (EST) activities and the sulfation of resveratrol.
Negative_regulation (inhibitor) of SULT1A1 in liver
1) Confidence 0.55 Published 2004 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 15487807 Disease Relevance 0 Pain Relevance 0.13
Mefenamic acid is therefore a potent and selective inhibitor of human liver SULT1A1.
Negative_regulation (inhibitor) of SULT1A1 in liver
2) Confidence 0.55 Published 2004 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 15487807 Disease Relevance 0 Pain Relevance 0.08
In contrast, the agent 2,6-dichloro-4-nitrophenol, an inhibitor of the enzyme phenol sulfotransferase, did not interfere with DA uptake, but did inhibit DAS formation in a concentration-dependent manner.
Negative_regulation (inhibitor) of sulfotransferase associated with dopamine
3) Confidence 0.51 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3492601 Disease Relevance 0 Pain Relevance 0.61
Although less potent in this intact cell system (IC50 2-5 microM), quercetin was still more potent than 2,6-dichloro-4-nitrophenol, the classical P-form PST inhibitor that has been shown to be an inhibitor also in vivo.
Negative_regulation (inhibitor) of PST
4) Confidence 0.38 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8742236 Disease Relevance 0.09 Pain Relevance 0.12
Curcumin, genistein, and ellagic acid (other polyphenolic natural products) were also inhibitors of P-form PST, with IC50 values of 0.38-34.8 microM.
Negative_regulation (inhibitors) of PST
5) Confidence 0.38 Published 1996 Journal Drug Metab. Dispos. Section Abstract Doc Link 8742236 Disease Relevance 0.09 Pain Relevance 0.15
The SULT1 family is divided into five subfamilies, designated SULT1A, SULT1B, SULT1C, SULT1D, and SULT1E.
Negative_regulation (designated) of SULT1A
6) Confidence 0.18 Published 2009 Journal PPAR Research Section Body Doc Link PMC2724710 Disease Relevance 0 Pain Relevance 0.11

General Comments

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