INT37181

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Context Info
Confidence 0.37
First Reported 1986
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.83
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Itpr3) transport (Itpr3) endoplasmic reticulum (Itpr3)
nucleolus (Itpr3) nucleus (Itpr3) transmembrane transport (Itpr3)
Itpr3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 2 99.96 Very High Very High Very High
bradykinin 30 99.82 Very High Very High Very High
Opioid 3 98.92 Very High Very High Very High
algogenic 1 96.92 Very High Very High Very High
Enkephalin 4 93.12 High High
agonist 3 82.88 Quite High
opiate 1 82.56 Quite High
dorsal root ganglion 4 79.16 Quite High
Disease Link Frequency Relevance Heat
Pain 1 96.74 Very High Very High Very High
Ganglion Cysts 4 79.16 Quite High
Bordatella Infection 2 79.12 Quite High
Neuroblastoma 6 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Bradykinin-induced IP3 release was blocked by several novel bradykinin analogues.
Negative_regulation (blocked) of Localization (release) of IP3 associated with bradykinin
1) Confidence 0.37 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3494104 Disease Relevance 0.37 Pain Relevance 0.55
A23187, a Ca2+ ionophore, produced a 37% decrease in IP3 concentration. 12-O-Tetradecanoylphorbol-13-acetate, which mimics the effects of DG and activates protein kinase C, inhibited IP3 release by 80%.
Negative_regulation (inhibited) of Localization (release) of IP3 associated with kinase c
2) Confidence 0.37 Published 1987 Journal J. Neurochem. Section Abstract Doc Link 3494104 Disease Relevance 0.23 Pain Relevance 0.62
These results show that pain-inducing BK has a major acute stimulatory effect on receptor-phospholipase C-coupled IP3 release, the opioid peptide DADLE has no such effect and, DADLE does not block the IP3 release induced by BK.
Negative_regulation (block) of Localization (release) of IP3 associated with algogenic, opioid and bradykinin
3) Confidence 0.24 Published 1986 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 3516143 Disease Relevance 0.23 Pain Relevance 0.79

General Comments

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