INT37204

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Context Info
Confidence 0.65
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.76
Pain Relevance 1.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
immune cells 1
hair 1
HCL1 (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 100.00 Very High Very High Very High
Desipramine 1 99.98 Very High Very High Very High
Inflammatory mediators 14 99.74 Very High Very High Very High
chemokine 9 99.52 Very High Very High Very High
antagonist 18 95.84 Very High Very High Very High
substance P 27 95.40 Very High Very High Very High
Nicotine 1 94.96 High High
antidepressant 1 94.32 High High
fluoxetine 2 91.24 High High
depression 1 88.72 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 49 99.54 Very High Very High Very High
Skin Cancer 2 90.24 High High
Seasonal Affective Disorder 1 89.44 High High
Fatigue 19 68.24 Quite High
Sprains And Strains 2 62.56 Quite High
Gastroesophageal Reflux Disease 12 60.32 Quite High
Disorders Of Creatine Metabolism 1 55.92 Quite High
Hyperplasia 1 53.56 Quite High
Syndrome 5 50.00 Quite Low
Pain 4 44.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monoclonal antibodies used in this study were CD19 allophycocyanin (APC) (clone SJ25C1) and CD22 phycoerythrin (PE) (clone S-HCL-1).
Gene_expression (phycoerythrin) of HCL-1
1) Confidence 0.65 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779377 Disease Relevance 0.12 Pain Relevance 0
We have established a serum free human melanocyte-keratinocyte coculture system to study the behavior and functional abilities of melanocytes expressing MC1R red hair color (RHC) variants in order to identify differences from their wild type (WT) counterparts.
Gene_expression (expressing) of hair color in hair associated with melanocortin 1 receptor
2) Confidence 0.58 Published 2008 Journal J. Cell. Physiol. Section Abstract Doc Link 17960564 Disease Relevance 0.15 Pain Relevance 0.39
Phenelzine sulfate, desipramine HCl and bright artificial light produced the same effect.
Gene_expression (produced) of HCl associated with desipramine
3) Confidence 0.48 Published 1987 Journal Life Sci. Section Abstract Doc Link 3497323 Disease Relevance 0.09 Pain Relevance 0.36
Thus the inflammatory mediators produced by HCl exposure may act as chemokines, as immune cells activators, or both.
Gene_expression (exposure) of HCl in immune cells associated with chemokine and inflammatory mediators
4) Confidence 0.05 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.40 Pain Relevance 0.79

General Comments

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