INT37215

Context Info Confidence 0.45 First Reported 1982 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 18 Total Number 19 Disease Relevance 8.99 Pain Relevance 4.87

Anatomy Link Frequency plasma 1 smooth muscle 1 anterior 1 posterior 1 neural 1 SMN1 (Homo sapiens)

Pain Link Frequency Relevance Heat Thalamus 13 99.92 Enkephalin 6 99.44 insula 35 99.16 Pain 157 97.88 qutenza 3 97.68 Fibrositis 12 97.04 fibrosis 18 95.64 opioid receptor 2 93.32 Anterior cingulate cortex 19 91.56 lidocaine 2 91.32

Disease Link Frequency Relevance Heat Urological Neuroanatomy 6 100.00 Multiple System Atrophy 1 99.92 Cancer 15 99.76 Tics 102 99.28 Obesity 6 99.20 Pain 230 97.88 Sleep Disorders 13 97.04 Ureteral Obstruction 25 95.88 Neurilemmoma 5 95.84 Fibrosis 32 95.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Immunohistochemically, the tumor cells were positive for vimentin, SMA, MSA, CD34, laminin and a scattered number for S-100.

Positive_regulation (positive) of SMA associated with cancer and multiple system atrophy

1) Confidence 0.45 Published 1998 Journal Acta Ophthalmol Scand Section Abstract Doc Link 9881563 Disease Relevance 0.99 Pain Relevance 0.08

The data indicate that exposure of the intestinal lumen to an afferent nerve stimulant or nutrient induced a dichotomous pattern of blood flow changes, an increase in the SMA and a reduction in MAT.

Positive_regulation (increase) of SMA in MAT associated with obesity

2) Confidence 0.28 Published 2001 Journal Dig. Dis. Sci. Section Abstract Doc Link 11414297 Disease Relevance 0.50 Pain Relevance 0.18

Both perspectives were associated by the activation of common neural networks in the SMA, the precentral gyrus and the precuneus.

Positive_regulation (activation) of SMA in neural

3) Confidence 0.26 Published 2007 Journal J Neural Transm Section Body Doc Link PMC2797860 Disease Relevance 0 Pain Relevance 0.50

The patient's act of marking the occurrence of tic events perhaps also contributed to activation of M1, SMA, and posterior ACC with both evoked and spontaneous EVs.

Positive_regulation (activation) of SMA in posterior associated with tics

4) Confidence 0.23 Published 2007 Journal Mol Pain Section Body Doc Link PMC2217520 Disease Relevance 0.73 Pain Relevance 0.41

Treatment of cells growing out from human rotator cuff explants with TGF-beta1 significantly increased the amount of SMA evaluated by Western blot analysis.

Positive_regulation (increased) of SMA

5) Confidence 0.23 Published 2001 Journal J. Orthop. Res. Section Abstract Doc Link 11347694 Disease Relevance 0.21 Pain Relevance 0.07

Ten minutes after ligation of the SMA, there was a considerable increase in peristalsis, IIP, and inability to fill the intestinal microcirculation by the three methods described.

Positive_regulation (increase) of SMA in SMA

6) Confidence 0.16 Published 1987 Journal J. Pediatr. Surg. Section Abstract Doc Link 3498812 Disease Relevance 0.70 Pain Relevance 0.12

The interlobular area was seldom immunoreactive for alpha-smooth muscle actin (alpha-SMA), a marker for myofibroblasts, but was usually positive for CD34, a human progenitor cell antigen.

Positive_regulation (immunoreactive) of alpha-SMA in smooth muscle

7) Confidence 0.16 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15189503 Disease Relevance 0.83 Pain Relevance 0.33

In contrast, the periductal area was usually immunoreactive for alpha-SMA, but usually negative for CD34 and immunopositive for bcl-2, indicating a continuously progressive state of fibrosis, in which 'pre-existing'alpha-SMA immunoreactivity in the interlobular area may change in nature and lead to CD34-positive fibrosis or apoptosis.

Positive_regulation (immunoreactive) of alpha-SMA associated with fibrosis and apoptosis

8) Confidence 0.16 Published 2004 Journal Pathol. Int. Section Abstract Doc Link 15189503 Disease Relevance 0.87 Pain Relevance 0.35

However, direct cortical stimulation of SMA has previously induced movements [6], so an alternative explanation could be that we were not able to efficiently stimulate SMA with TMS when the TMS was not accompanied by a voluntary effort, as was the case for the study by Haggard and Whitford [2].

Positive_regulation (stimulation) of SMA

9) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0

Haggard and Whitford [2] showed that TMS stimulation over SMA prior to a voluntary movement removed the sensory suppression effect, which normally accompanies voluntary movements [22].

Positive_regulation (stimulation) of SMA

10) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2952623 Disease Relevance 0 Pain Relevance 0

Immunohistochemically, the tumors were positive for S-100, vimentin, and neuron-specific enolase, and negative for HHF35, Alpha-SMA, and c-kit.

Positive_regulation (negative) of Alpha-SMA in neuron associated with cancer

11) Confidence 0.09 Published 2003 Journal Surg. Today Section Abstract Doc Link 14669089 Disease Relevance 1.18 Pain Relevance 0.08

In contrast, the desmoplastic reaction surrounding all 10 pancreatic adenocarcinoma specimens displayed intense interstitial staining for alpha-SMA, SMMHC, and collagen IV but no staining for von Willebrand factor and cluster of differentiation 31.

Positive_regulation (staining) of alpha-SMA

12) Confidence 0.07 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.07 Pain Relevance 0

Islet cell tumors demonstrated an increase in alpha-SMA staining, although this was not as marked as in ductal adenocarcinomas.

Positive_regulation (increase) of alpha-SMA

13) Confidence 0.07 Published 2002 Journal Surgery Section Body Doc Link 11854689 Disease Relevance 0.06 Pain Relevance 0

The areas of the anterior and mid-cingulate cortex, middle frontal cortex, SMA, thalamus, anterior insula, and basal ganglia displayed more activity in fibromyalgia patients [21,22].

Positive_regulation (cingulate) of SMA in anterior associated with insula, urological neuroanatomy, thalamus and fibrositis

14) Confidence 0.06 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC2935976 Disease Relevance 1.83 Pain Relevance 1.37

The more ventral part (VLO beta) is cytoarchitectonically distinct from the dorsal part (VLO alpha); the former receives input from the anterior part of Sm (Sma), while the latter receives input from the dorsal and ventral parts of Sm (Smd and Smv).

Positive_regulation (receives) of Sma in VLO

15) Confidence 0.02 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 6284805 Disease Relevance 0 Pain Relevance 0

GLP-2 administration at all doses significantly increased the SMA blood flow throughout the experiments.

Positive_regulation (increased) of SMA in blood

16) Confidence 0.01 Published 2007 Journal Regul. Pept. Section Abstract Doc Link 17346812 Disease Relevance 0 Pain Relevance 0.31

-SMA and activated smad2 (p-smad2) levels in proximal tubular epithelial cells.

Positive_regulation (activated) of SMA in proximal

17) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2823698 Disease Relevance 0.50 Pain Relevance 0

Pre-SMA also activates more before self-selected movements (such as DecBa responses) than before externally-commanded ones (like DirBa responses).

Positive_regulation (activates) of Pre-SMA

18) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2943904 Disease Relevance 0.08 Pain Relevance 0.43

Exogenous ENK administration accentuated SMA-H20%-induced increases in plasma NO levels, and their cardiovascular depressing effects were significantly greater when they were administered during SMA-H20% (vs. administration under baseline conditions).

Positive_regulation (increases) of SMA-H20 in plasma associated with enkephalin

19) Confidence 0.00 Published 2005 Journal Int J Immunopathol Pharmacol Section Abstract Doc Link 15698509 Disease Relevance 0.44 Pain Relevance 0.64

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