INT37227

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 19
Total Number 21
Disease Relevance 11.16
Pain Relevance 5.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (EGF) extracellular space (EGF) extracellular region (EGF)
plasma membrane (EGF)
Anatomy Link Frequency
platelet 2
foot 2
tears 1
epithelial cells 1
BUC 1
EGF (Homo sapiens)
Pain Link Frequency Relevance Heat
interstitial cystitis 192 99.28 Very High Very High Very High
chemokine 24 98.68 Very High Very High Very High
cytokine 141 98.28 Very High Very High Very High
cINOD 37 97.40 Very High Very High Very High
Inflammation 77 95.28 Very High Very High Very High
Opioid 3 95.00 High High
opioid receptor 4 91.20 High High
peptic ulcer disease 5 90.12 High High
palliative 5 72.04 Quite High
Pain 21 68.96 Quite High
Disease Link Frequency Relevance Heat
Eye Disease 65 100.00 Very High Very High Very High
Cancer 128 99.80 Very High Very High Very High
Diabetic Foot Ulcer 8 99.44 Very High Very High Very High
Peptic Ulcer 11 99.40 Very High Very High Very High
Interstitial Cystitis 192 99.28 Very High Very High Very High
Hepatocellular Cancer 89 98.36 Very High Very High Very High
Ulcers 43 97.36 Very High Very High Very High
INFLAMMATION 97 97.20 Very High Very High Very High
Breast Cancer 58 95.92 Very High Very High Very High
Diabetes Mellitus 5 95.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF receptor (EGFR) mRNA was regulated in a similar manner in LNCaP derivatives established during the second cycle of intermittent withdrawal.
Regulation (regulated) of EGF
1) Confidence 0.45 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0 Pain Relevance 0
EGF receptor (EGFR) mRNA was regulated in a similar manner in LNCaP derivatives established during the second cycle of intermittent withdrawal.
Regulation (regulated) of EGF
2) Confidence 0.44 Published 2004 Journal Prostate Section Body Doc Link 15065088 Disease Relevance 0 Pain Relevance 0
This indicated the beneficial effect on ulcers of oral administration of EGF with agents allowing it to remain at high levels in the stomach, whereas most reports suggested less effect of oral EGF on healing of gastroduodenal ulcers.
Regulation (effect) of EGF in stomach associated with ulcers and peptic ulcer
3) Confidence 0.36 Published 1994 Journal J. Gastroenterol. Hepatol. Section Abstract Doc Link 7881024 Disease Relevance 0.61 Pain Relevance 0.07
Due to its irreversible inhibition BIBW-2992 remains active in many EGF-R mutations, including the EGF-RvIII mutation, which has been reported in HNSCC.
Regulation (active) of EGF-R
4) Confidence 0.31 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2868849 Disease Relevance 0.37 Pain Relevance 0
Role of acid and salivary epidermal growth factor in gastric mucosal adaptation to naproxen in man.
Regulation (Role) of epidermal growth factor
5) Confidence 0.27 Published 1998 Journal Scand. J. Gastroenterol. Section Title Doc Link 9754723 Disease Relevance 0.19 Pain Relevance 0.19
To investigate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in advanced diabetic foot ulcers (DFU) A double-blind trial was carried out to test two rhEGF dose levels in type 1 or 2 diabetes patients with Wagner's grade 3 or 4 ulcers, with high risk of amputation.
Spec (investigate) Regulation (efficacy) of rhEGF in foot associated with diabetic foot ulcer, diabetes mellitus, ulcers and amputation
6) Confidence 0.27 Published 2007 Journal International wound journal Section Abstract Doc Link 17953679 Disease Relevance 0.76 Pain Relevance 0
EGF, fractalkine/CX3CL1, IL-1Ra, IP-10/CXCL10, and VEGF levels were the only molecules that were determined using the same reagents for both DED and control tears.
Regulation (control) of EGF in tears associated with eye disease
7) Confidence 0.26 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2874579 Disease Relevance 0.30 Pain Relevance 0.44
Changes in BUC membrane potassium conductance caused by altered levels of EGF and HB-EGF may therefore play a role in the pathophysiology of IC.
Regulation (altered) of EGF in BUC associated with interstitial cystitis
8) Confidence 0.25 Published 2007 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 16837648 Disease Relevance 0.98 Pain Relevance 0.95
To investigate the efficacy and safety of recombinant human epidermal growth factor (rhEGF) in advanced diabetic foot ulcers (DFU) A double-blind trial was carried out to test two rhEGF dose levels in type 1 or 2 diabetes patients with Wagner's grade 3 or 4 ulcers, with high risk of amputation.
Spec (investigate) Regulation (efficacy) of epidermal growth factor in foot associated with diabetic foot ulcer, diabetes mellitus, ulcers and amputation
9) Confidence 0.23 Published 2007 Journal International wound journal Section Abstract Doc Link 17953679 Disease Relevance 0.76 Pain Relevance 0
However, APF, HB-EGF, and EGF were the most sensitive and specific for IC, with anti-proliferative factor activity most clearly separating the interstitial cystitis and control groups (5).


Regulation (sensitive) of EGF associated with interstitial cystitis
10) Confidence 0.22 Published 2005 Journal BMC Urol Section Body Doc Link PMC1131910 Disease Relevance 1.34 Pain Relevance 1.07
There was no effect of drug or EGF treatment on total ERK1/2 expression.
Neg (no) Regulation (effect) of EGF
11) Confidence 0.20 Published 2005 Journal J Carcinog Section Body Doc Link PMC1208922 Disease Relevance 0.35 Pain Relevance 0
In preneoplastic cells, the aberrant signaling that was detected most frequently was an elevated activation of ERK, a reduced or increased IL-6 and EGF response, and an increased LIF response.
Regulation (response) of EGF
12) Confidence 0.19 Published 2005 Journal BMC Cancer Section Abstract Doc Link PMC1289280 Disease Relevance 0.51 Pain Relevance 0.13
Additional treatment with Sulindac metabolites did not alter the EGF-elevated phospho-AKT level.


Neg (not) Regulation (alter) of EGF
13) Confidence 0.16 Published 2004 Journal Cancer Cell Int Section Body Doc Link PMC425591 Disease Relevance 0.42 Pain Relevance 0
Similarly, primary wallaby epithelial cells shows a growth response to EGF while the WalBC cell line was not EGF responsive as these maximal doses.
Neg (not) Regulation (responsive) of EGF in epithelial cells
14) Confidence 0.16 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2263075 Disease Relevance 0.34 Pain Relevance 0
There were no sex differences or age-related changes in the salivary IR-hEGF levels.
Regulation (changes) of hEGF
15) Confidence 0.14 Published 1987 Journal Hepatogastroenterology Section Abstract Doc Link 3499370 Disease Relevance 1.03 Pain Relevance 0.32
Clinical and experimental work supports the view that the epidermal growth factor receptor (EGFR) is a relevant target for cancer therapy.
Regulation (target) of epidermal growth factor associated with cancer
16) Confidence 0.14 Published 2007 Journal Cancer Invest. Section Abstract Doc Link 18027154 Disease Relevance 0.55 Pain Relevance 0.07
In addition, the receptor-mediated JNK activation was dependent on Src family tyrosine kinases, but independent of phosphatidylinositol-3 kinase and EGF receptor tyrosine kinases.
Neg (independent) Regulation (independent) of EGF
17) Confidence 0.12 Published 2003 Journal J. Neurochem. Section Abstract Doc Link 12558970 Disease Relevance 0.20 Pain Relevance 0.48
However, APF, HB-EGF, and EGF were the most sensitive and specific for IC, with anti-proliferative factor activity most clearly separating the interstitial cystitis and control groups (5).


Regulation (sensitive) of EGF associated with interstitial cystitis
18) Confidence 0.10 Published 2005 Journal BMC Urol Section Body Doc Link PMC1131910 Disease Relevance 1.35 Pain Relevance 1.07
These include drugs targeted against the epidermal growth factor, platelet-derived growth factor, vascular endothelial growth factor, src kinase, histone deacetylase, the proteasome, and mesothelin.
Regulation (targeted) of epidermal growth factor in platelet
19) Confidence 0.04 Published 2008 Journal Curr Treat Options Oncol Section Abstract Doc Link PMC2782121 Disease Relevance 0.28 Pain Relevance 0
The observed inhibitory effects were dose dependent in both URG and RG extracts.
Regulation (dependent) of URG
20) Confidence 0.04 Published 2008 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2635732 Disease Relevance 0.18 Pain Relevance 0.31

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