INT37253

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Context Info
Confidence 0.37
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 6.13
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (PTPRC)
Anatomy Link Frequency
muscle 1
bands 1
stomach 1
urine 1
T lymphocytes 1
PTPRC (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 2 99.58 Very High Very High Very High
Inflammation 148 88.24 High High
Inflammatory response 24 86.88 High High
addiction 3 84.68 Quite High
Bile 7 81.64 Quite High
anesthesia 13 80.04 Quite High
Central nervous system 2 78.44 Quite High
rheumatoid arthritis 1 70.80 Quite High
Arthritis 21 68.24 Quite High
Osteoarthritis 1 67.04 Quite High
Disease Link Frequency Relevance Heat
Disease 69 99.58 Very High Very High Very High
Ulcers 2 99.42 Very High Very High Very High
Muscle Disease 116 98.74 Very High Very High Very High
Fatigue 26 95.88 Very High Very High Very High
Chronic Fatigue Syndrome 65 95.12 Very High Very High Very High
Apoptosis 112 90.64 High High
Postoperative Hemorrhage 6 90.20 High High
INFLAMMATION 166 88.24 High High
Cancer 89 85.52 High High
Pancreatitis 1 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Human gastric mucus from a histologically normal stomach also had the characteristics of a weak viscoelastic gel, although that from patients with peptic ulcer disease has a significantly reduced content of polymeric glycoprotein.
Negative_regulation (reduced) of glycoprotein in stomach associated with peptic ulcer disease and disease
1) Confidence 0.37 Published 1987 Journal Biorheology Section Abstract Doc Link 3502763 Disease Relevance 0.36 Pain Relevance 0.10
The glycoprotein polymeric structure is deficient in antral mucus from patients with peptic ulcer disease.
Negative_regulation (deficient) of glycoprotein associated with peptic ulcer disease and disease
2) Confidence 0.28 Published 1985 Journal Dig. Dis. Sci. Section Abstract Doc Link 3932055 Disease Relevance 0.20 Pain Relevance 0.14
Our group alongside others have established that OECs immunophenotype consists of multiple endothelial markers and complete absence of haematopoietic markers such as CD45 and CD14 [23,32].
Negative_regulation (absence) of CD45
3) Confidence 0.18 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.33 Pain Relevance 0.07
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Negative_regulation (positive) of CD45
4) Confidence 0.09 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.05 Pain Relevance 0.10
In addition, CD45 has long been shown to be relevant for LTB4- and C5a-induced chemotaxis and low affinity FcãR signalling in neutrophils [258,259]: since ROS have been shown to be potent inhibitors of CD45 [260], they may interfere with physiological responses to these chemoattractants.
Negative_regulation (inhibitors) of CD45 in neutrophils
5) Confidence 0.09 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.29 Pain Relevance 0.12
Expression of this gene set was also significantly repressed in LCA class 3 (p = 0.04) and marginally so in LCA class 5 (p = 0.09) when compared to control subjects in LCA classes 0 and 2.
Negative_regulation (repressed) of LCA
6) Confidence 0.05 Published 2008 Journal Behav Brain Funct Section Body Doc Link PMC2569951 Disease Relevance 0.92 Pain Relevance 0
Second, ROS-mediated inhibitory modulation of the activity of PTPs (for example, CD45, SHP-1, HePTP) has been shown to regulate signalling events involved in the activation of T lymphocytes [256,257].
Negative_regulation (modulation) of CD45 in T lymphocytes
7) Confidence 0.04 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.42 Pain Relevance 0.16
Ulinastatin (Ulistin®, Han Lim Pharmaceutical, Seoul, Korea), a urinary trypsin inhibitor, is a glycoprotein derived from human urine [12].
Negative_regulation (inhibitor) of glycoprotein in urine
8) Confidence 0.04 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2872884 Disease Relevance 0.84 Pain Relevance 0.27
As in the case of the aforementioned membrane-bound glycoprotein, NEP activity decreased significantly in CCRCC (fourfold), ChRCC (fivefold) and RO (sevenfold) when compared with the normal tissue samples.
Negative_regulation (decreased) of glycoprotein
9) Confidence 0.02 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2876082 Disease Relevance 0.57 Pain Relevance 0
In all cases, the HIBM patients' NCAM bands ran lower than the control, reflecting a decreased sialic acid content of this glycoprotein.
Negative_regulation (decreased) of glycoprotein in bands associated with muscle disease
10) Confidence 0.01 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1790898 Disease Relevance 0.27 Pain Relevance 0.05
A third possibility is that the muscle we biopsied, the quadriceps, had minimal baseline reduction in glycoprotein sialylation so that any increased sialylation after therapy could not be appreciated.
Negative_regulation (reduction) of glycoprotein in muscle
11) Confidence 0.01 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1790898 Disease Relevance 0.57 Pain Relevance 0.20
The authors postulated that PLD may act as a p-glycoprotein (MDR1) inhibitor, thus reducing the excretion of vinorelbine.24

Phase I and II development of PLD

Negative_regulation (inhibitor) of glycoprotein
12) Confidence 0.01 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731020 Disease Relevance 0.30 Pain Relevance 0.04

General Comments

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