INT37254

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Context Info
Confidence 0.36
First Reported 1984
Last Reported 1986
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.76
Pain Relevance 1.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (MTM1) cytoplasm (MTM1)
Anatomy Link Frequency
trunks 1
MTM1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 11 98.40 Very High Very High Very High
antagonist 2 98.24 Very High Very High Very High
agonist 9 90.56 High High
depression 2 85.44 High High
Clonidine 2 81.28 Quite High
ketamine 1 70.16 Quite High
Disease Link Frequency Relevance Heat
Miosis 1 90.60 High High
Ocular Hypertension 7 86.88 High High
Depression 2 85.44 High High
Hypotension 1 57.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, intra-arterially administered xylazine (10, 33 and 100 micrograms) produced dose-related inhibition of contractions of the CNM elicited by electrically stimulating the pre- and postganglionic sympathetic trunks without altering the response to i.a. norepinephrine (10 micrograms).
Negative_regulation (inhibition) of CNM in trunks
1) Confidence 0.36 Published 1986 Journal J Ocul Pharmacol Section Abstract Doc Link 3503099 Disease Relevance 0.54 Pain Relevance 0.15
For example, the inhibitory effects of an ergoline derivative LY141865 on neuronally mediated contractions of the CNM could be reversed (or prevented) by relatively selective DA2 antagonists, such as sulpiride and domperidone, but not by relatively selective alpha 2-antagonists, such as yohimbine and rauwolscine.
Negative_regulation (reversed) of CNM associated with dopamine and antagonist
2) Confidence 0.01 Published 1984 Journal Curr. Eye Res. Section Abstract Doc Link 6150810 Disease Relevance 0.22 Pain Relevance 0.94

General Comments

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