INT37294

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Context Info
Confidence 0.54
First Reported 1986
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.27
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Ece1) peptidase activity (Ece1) plasma membrane (Ece1)
Anatomy Link Frequency
blood 1
epithelial cell 1
endothelium 1
Ece1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 3 96.84 Very High Very High Very High
noradrenaline 2 92.48 High High
qutenza 2 91.88 High High
anesthesia 6 91.84 High High
Spinal cord 9 89.44 High High
antagonist 8 88.36 High High
agonist 5 87.60 High High
tetrodotoxin 2 81.68 Quite High
substance P 2 77.60 Quite High
intrathecal 2 50.40 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 1 97.60 Very High Very High Very High
Injury 6 94.52 High High
Heart Rate Under Development 8 85.68 High High
Increased Venous Pressure Under Development 2 72.48 Quite High
Hypertension 1 67.44 Quite High
Pressure And Volume Under Development 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study using phosphoramidon, a potent inhibitor of endothelin-converting enzyme-1 (ECE-1), we investigated the influence of ET-1 on the expression of constitutive (cNOS) and inducible nitric oxide synthase (NOS-2) during gastric mucosal injury caused by indomethacin.
Negative_regulation (inhibitor) of ECE-1 associated with injury
1) Confidence 0.54 Published 2000 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 11145282 Disease Relevance 0.17 Pain Relevance 0.10
In this study using phosphoramidon, a potent inhibitor of endothelin-converting enzyme-1 (ECE-1), we investigated the influence of ET-1 on the expression of constitutive (cNOS) and inducible nitric oxide synthase (NOS-2) during gastric mucosal injury caused by indomethacin.
Negative_regulation (inhibitor) of endothelin-converting enzyme-1 associated with injury
2) Confidence 0.54 Published 2000 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 11145282 Disease Relevance 0.17 Pain Relevance 0.10
Furthermore, big ET-1 (100 pmol) caused toxic effects and delayed cardiovascular changes which were prevented by the prior i.t. administration of either BQ-123 (65 nmol) or 100 nmol phosphoramidon, an endothelin-converting enzyme (ECE) inhibitor.
Negative_regulation (inhibitor) of endothelin-converting enzyme
3) Confidence 0.39 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522926 Disease Relevance 0.29 Pain Relevance 0.30
Furthermore, big ET-1 (100 pmol) caused toxic effects and delayed cardiovascular changes which were prevented by the prior i.t. administration of either BQ-123 (65 nmol) or 100 nmol phosphoramidon, an endothelin-converting enzyme (ECE) inhibitor.
Negative_regulation (inhibitor) of ECE
4) Confidence 0.39 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522926 Disease Relevance 0.28 Pain Relevance 0.28
Pretreatment with phosphoramidon produced dose-dependent reduction in the extent of mucosal damage caused by indomethacin, accompanied by a significant recovery in the expression of cNOS, and a marked decline in ECE-1, epithelial cell apoptosis and the mucosal level of ET-1.
Negative_regulation (decline) of ECE-1 in epithelial cell
5) Confidence 0.35 Published 2000 Journal Scand. J. Gastroenterol. Section Body Doc Link 11145282 Disease Relevance 0.06 Pain Relevance 0
The potentiating effect of BQ-788 was not modified in arterial segments without endothelium or pretreated with the inhibitor of nitric oxide synthesis N(W)-nitro-L-arginine (L-NA, 10(-4) M) or with the inhibitor of endothelin converting enzyme N-(alpha-rhamnopyranosyloxy-hydroxyphosphinyl)-leu-trp (phosphoramidon, 10(-4) M).
Negative_regulation (inhibitor) of endothelin converting enzyme in endothelium
6) Confidence 0.27 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10611437 Disease Relevance 0.13 Pain Relevance 0.27
This response was sensitive to phosphoramidon and [Phe22]big endothelin-1-(19-37), two inhibitors of endothelin-converting enzyme.
Negative_regulation (inhibitors) of endothelin-converting enzyme
7) Confidence 0.21 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8982672 Disease Relevance 0.17 Pain Relevance 0.32
Pretreatment of rats with captopril, an inhibitor of angiotensin I converting enzyme, prevented the impairment of renal hemodynamics by pentobarbital without restoring blood pressure.
Negative_regulation (inhibitor) of I converting enzyme in blood
8) Confidence 0.08 Published 1986 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3512818 Disease Relevance 0 Pain Relevance 0.38

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