INT373

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Context Info
Confidence 0.61
First Reported 1975
Last Reported 2011
Negated 12
Speculated 2
Reported most in Abstract
Documents 37
Total Number 39
Disease Relevance 17.86
Pain Relevance 11.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
LDH 2
mammary gland 1
plasma 1
macrophage 1
brain 1
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
spinal dorsal horn 76 100.00 Very High Very High Very High
gABA 22 100.00 Very High Very High Very High
adenocard 13 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
Cholecystokinin 10 100.00 Very High Very High Very High
ischemia 140 99.72 Very High Very High Very High
cerebral cortex 3 99.64 Very High Very High Very High
Pain 35 99.60 Very High Very High Very High
Paracetamol 11 99.46 Very High Very High Very High
medulla 2 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 25 100.00 Very High Very High Very High
Toxicity 20 99.92 Very High Very High Very High
Thrombosis Related Under Development 15 99.82 Very High Very High Very High
Hepatitis Virus Infection 1 99.80 Very High Very High Very High
Cv Unclassified Under Development 92 99.72 Very High Very High Very High
Pain 34 99.60 Very High Very High Very High
Muscular Dystrophy 18 99.54 Very High Very High Very High
Middle Cerebral Artery Infarction 47 98.64 Very High Very High Very High
Jaundice 2 98.36 Very High Very High Very High
INFLAMMATION 106 97.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Etherization caused twofold changes in synovial and articular cartilage G-6-PDH, LDH, CPK, glutamic DH, and ICDH based on tissue dry weight and DNA content.
Regulation (changes) of LDH in articular cartilage
1) Confidence 0.61 Published 1975 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 1139446 Disease Relevance 0.18 Pain Relevance 0.34
Although other test drugs have no effect on LDH in urine phenylbutazone and indomethacin elevated GPT and A1-P, oxyphenbutazone did gamma-GT and anthranilic acid derivatives did Al-P and gamma-GT.
Neg (no) Regulation (effect) of LDH in urine
2) Confidence 0.59 Published 1978 Journal J Toxicol Sci Section Abstract Doc Link 34731 Disease Relevance 0.16 Pain Relevance 0.39
However, no significant changes in LDH activity were observed in the rats treated only with the aqueous extract of Embelia ribes, as compared to the sham rats [Table 1].


Neg (no) Regulation (changes) of LDH
3) Confidence 0.52 Published 2008 Journal Indian Journal of Pharmacology Section Body Doc Link PMC2792627 Disease Relevance 0.55 Pain Relevance 0.04
Changes in extracellular levels of transmitter amino acids and lactic acid dehydrogenase (LDH) in rat cerebral cortex during and following four-vessel occlusion elicited global cerebral ischemia were examined using a cortical cup technique.
Spec (examined) Regulation (Changes) of LDH in cerebral cortex associated with cv general 4 under development, ischemia and cerebral cortex
4) Confidence 0.47 Published 1994 Journal Brain Res. Bull. Section Abstract Doc Link 7915962 Disease Relevance 0.28 Pain Relevance 0.63
In general, NNT had no effect on serum enzymes (SGOT, SGPT, LDH, HBDH), but it increased blood urea nitrogen (BUN) and serum creatinine 24 h after administration.
Neg (no) Regulation (effect) of LDH in blood
5) Confidence 0.45 Published 1984 Journal J Toxicol Environ Health Section Abstract Doc Link 6492189 Disease Relevance 0.57 Pain Relevance 0.21
Removal of olfactory bulbs in rats did not affect LDH activity (Figure 2), whereas caspase-3 activity was significantly enhanced (0.26 ± 0.004 OD arbitrary units/mg protein in control group vs 0.37 ± 0.004 OD arbitrary units/mg protein in OBX group, p < 0.001) (Figure 2).
Neg (not) Regulation (affect) of LDH in olfactory bulbs
6) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2518376 Disease Relevance 0.30 Pain Relevance 0.03
BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) at 40 microM markedly inhibited glutathione reductase and also strongly potentiated cell killing by AAP but did not significantly influence segmental cytoplasmic contraction or LDH release in response to AFB1.
Neg (not) Regulation (influence) of LDH associated with paracetamol
7) Confidence 0.41 Published 1986 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 3088775 Disease Relevance 0.28 Pain Relevance 0.71
The heat threshold over the PSH and the pressure threshold over the LDH were unaffected by the bilateral saphenous transection, demonstrating that following loose sciatic ligation both of these thresholds are mediated by the sciatic nerve.
Neg (unaffected) Regulation (unaffected) of LDH in sciatic nerve associated with sciatic nerve
8) Confidence 0.38 Published 1993 Journal Pain Section Abstract Doc Link 8121690 Disease Relevance 0.68 Pain Relevance 0.62
No change in LDH or CS present in the cytosol fraction relative to whole cell activity was observed with any of the cardioprotective interventions.
Neg (No) Regulation (change) of LDH
9) Confidence 0.29 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15764678 Disease Relevance 0.23 Pain Relevance 0.42
The changes of LDH activity in plasma also correlated with the result of the infarct volume.
Regulation (changes) of LDH in plasma
10) Confidence 0.27 Published 2004 Journal Life Sci. Section Abstract Doc Link 15010264 Disease Relevance 0.65 Pain Relevance 0.44
The structural integrity of synaptosomes was controlled by electron microscopy, by changes in lactate dehydrogenase activity as well as by the ability of synaptosomes to maintain the transmembrane potential, using the fluorescent probe 1-anilino-8-naphthalenesulfonate.
Regulation (changes) of lactate dehydrogenase
11) Confidence 0.27 Published 1984 Journal Biokhimiia Section Abstract Doc Link 6087936 Disease Relevance 0 Pain Relevance 0.35
Such changes in LDH activity and albumin concentration reflected ischemic change, and the newly developed technique may be useful for the monitoring of extracellular dynamics of proteins with molecular weight less than 200 kDa.
Regulation (changes) of LDH
12) Confidence 0.27 Published 1996 Journal Anal. Biochem. Section Abstract Doc Link 8660563 Disease Relevance 0.10 Pain Relevance 0.11
We examined the temporal alteration of serum CK and LDH levels during episodes of pulmonary thrombosis experienced in 7 DMD patients who fulfilled the following diagnostic criteria: 1. sudden onset of dyspnea, chest pain, and hypoxia; 2. abnormal coagulation profile or abnormal chest CT findings, such as peripheral wedged shaped shadow and; 3. pneumothorax ruled out from X-ray findings.
Spec (examined) Regulation (alteration) of LDH in chest associated with angina, hypoxia, muscular dystrophy, pneumothorax, dyspnea and thrombosis related under development
13) Confidence 0.26 Published 2000 Journal Rinsho Shinkeigaku Section Abstract Doc Link 10825803 Disease Relevance 1.12 Pain Relevance 0.09
On univariate analysis, 11 of 27 parameters significantly affected survival, namely performance status, primary cancer, fatigue, dyspnea, use of strong analgesics, brain metastases, leukocytosis, lactate dehydrogenase (LDH), depression, and anxiety.
Regulation (affected) of LDH in brain
14) Confidence 0.26 Published 2007 Journal J. Clin. Oncol. Section Body Doc Link 17664480 Disease Relevance 0.06 Pain Relevance 0
The baseline condition in these animals was also characterized by up-regulation of seven genes (encoding members of GABA, cholecystokinin, histamine, serotonin, and neurotensin systems) in the LDH ipsilateral to the neonatally-injured paw.
Regulation (regulation) of LDH in LDH associated with gaba, spinal dorsal horn, serotonin and cholecystokinin
15) Confidence 0.24 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1242251 Disease Relevance 0.31 Pain Relevance 1.25
A modified lactic acid dehydrogenase(LDH) release assay was done to assess the NK cell activity.
Regulation (modified) of LDH in NK cell
16) Confidence 0.23 Published 2008 Journal Zhong Nan Da Xue Xue Bao Yi Xue Ban Section Body Doc Link 18544843 Disease Relevance 0.05 Pain Relevance 0
In cases of acute viral hepatitis, hepatic LDH concentration is altered in about 50% of the patients, with values typically only slightly above the reference limit [30].
Regulation (altered) of LDH associated with hepatitis virus infection
17) Confidence 0.22 Published 2010 Journal Scientia Pharmaceutica Section Body Doc Link PMC3007612 Disease Relevance 0.21 Pain Relevance 0.03
In particular, at baseline, twelve genes (representing GABA, serotonin, adenosine, neuropeptide Y, cholecystokinin, opioid, tachykinin and interleukin systems) were up-regulated in the bilateral LDH of the former animals.
Regulation (regulated) of LDH in LDH associated with adenocard, gaba, spinal dorsal horn, neuropeptide, opioid, cholecystokinin and serotonin
18) Confidence 0.21 Published 2005 Journal Mol Pain Section Abstract Doc Link PMC1242251 Disease Relevance 0.36 Pain Relevance 1.22
The concentrations of TP, ALB and level of IL-10 in intestine in group M decreased significantly while the concentrations of S/L, LDH and the levels of IL-6 and TNF-?
Regulation (concentrations) of LDH in intestine
19) Confidence 0.21 Published 2008 Journal BMC Gastroenterol Section Abstract Doc Link PMC2564972 Disease Relevance 0.26 Pain Relevance 0.08
However, these patients appear to have higher LDH values and bone pain as well as a poor prognosis and higher risk to develop SRE.
Regulation (values) of LDH associated with pain
20) Confidence 0.20 Published 2010 Journal BMC Urol Section Body Doc Link PMC3022602 Disease Relevance 1.36 Pain Relevance 0.25

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