INT37300

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Context Info
Confidence 0.27
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.37
Pain Relevance 0.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi) carbohydrate metabolic process (Gpi) cytoplasm (Gpi)
cytosol (Gpi) extracellular space (Gpi) extracellular region (Gpi)
Anatomy Link Frequency
striatum 1
stomach 1
Gpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 206 100.00 Very High Very High Very High
Neurotransmitter 196 98.48 Very High Very High Very High
antagonist 39 93.84 High High
agonist 66 81.76 Quite High
dopamine receptor 58 79.40 Quite High
gABA 108 75.04 Quite High
Enkephalin 27 75.00 Quite High
Somatostatin 35 68.72 Quite High
GABAergic 40 61.28 Quite High
positron emission tomography 8 43.28 Quite Low
Disease Link Frequency Relevance Heat
Catalepsy 2 94.56 High High
Parkinson's Disease 42 93.84 High High
Congenital Anomalies 6 92.00 High High
Movement Disorders 4 87.60 High High
Disease 58 31.36 Quite Low
Hypertension 18 5.00 Very Low Very Low Very Low
Sleep Disorders 16 5.00 Very Low Very Low Very Low
Affective Disorder 16 5.00 Very Low Very Low Very Low
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Neuroleptic Malignant Syndrome 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is likely that these drug effects are in large part secondary to activation or inactivation of striatal D2LRs, and are transmitted to GPi via the indirect pathway.
Localization (transmitted) of GPi
1) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.19 Pain Relevance 0.21
GPi activity is indirectly under the control of dopamine released in the striatum, via the direct and indirect pathways.
Localization (released) of GPi in striatum associated with dopamine
2) Confidence 0.27 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2987554 Disease Relevance 0.18 Pain Relevance 0.31
Bombesin-like immunoreactivity (BLI), a putative peptidergic neurotransmitter of the gastrointestinal intrinsic nervous system is released from the isolated perfused rat stomach in response to the classical neurotransmitter acetylcholine and in response to other putative peptidergic neurotransmitters such as vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI) or growth hormone releasing factor (GRF).
Localization (releasing) of PHI in stomach associated with neurotransmitter
3) Confidence 0.15 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3513044 Disease Relevance 0 Pain Relevance 0.25
PHI is found in abundance in the SCN and is co-localized [162,163].
Localization (localized) of PHI
4) Confidence 0.02 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06
VIP and PHI are structurally related to PACAP.
Localization (related) of PHI
5) Confidence 0.01 Published 2006 Journal J Circadian Rhythms Section Body Doc Link PMC1402333 Disease Relevance 0 Pain Relevance 0.06

General Comments

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