INT3732

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Context Info
Confidence 0.01
First Reported 1977
Last Reported 1985
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) plasma membrane (Neu1) lysosome (Neu1)
Anatomy Link Frequency
neutrophils 6
Neu1 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 5 97.82 Very High Very High Very High
Inflammation 6 96.76 Very High Very High Very High
Analgesic 2 90.00 High High
Osteoarthritis 2 75.84 Quite High
aspirin 2 25.00 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 97.70 Very High Very High Very High
Osteoarthritis 3 77.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Anti-inflammatory activity of the nonsteroidal anti-inflammatory drugs has been ascribed to prostaglandin synthesis inhibition; recent studies suggest additional effects based on inhibition of neutrophil aggregation, superoxide radical generation, and lysosomal enzyme release.
Negative_regulation (inhibition) of Localization (release) of lysosomal enzyme in neutrophil associated with inflammation and cinod
1) Confidence 0.01 Published 1985 Journal Am. J. Med. Section Abstract Doc Link 3904439 Disease Relevance 0.85 Pain Relevance 0.61
PGE1, PGE2, PGA1, PGA2, PGB1 and PGB2 reduced lysosomal enzyme release from cytochalasin B-treated neutrophils.
Negative_regulation (reduced) of Localization (release) of lysosomal enzyme in neutrophils
2) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.10
Naproxen, chloroquine and indomethacin inhibited particle uptake by and lysosomal enzyme secretion from neutrophils incubated with zymosan in Krebs-Ringer phosphate medium, pH 7.4, at 37 degrees C.
Negative_regulation (inhibited) of Localization (secretion) of lysosomal enzyme in neutrophils
3) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.04

General Comments

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