INT37335

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Context Info
Confidence 0.51
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 45
Total Number 45
Disease Relevance 24.36
Pain Relevance 4.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Nsdhl) endoplasmic reticulum (Nsdhl)
Anatomy Link Frequency
brain 3
embryo 3
liver 3
stem cells 3
amniotic fluid 2
Nsdhl (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 78 99.92 Very High Very High Very High
cytokine 52 97.10 Very High Very High Very High
Clonidine 1 93.44 High High
Dopamine 910 93.26 High High
Hippocampus 130 92.16 High High
Inflammation 37 91.84 High High
Antihistamine 1 91.76 High High
Potency 111 88.24 High High
Locus ceruleus 260 87.84 High High
amygdala 52 85.44 High High
Disease Link Frequency Relevance Heat
Ascariasis 34 100.00 Very High Very High Very High
Cirrhosis 9 99.96 Very High Very High Very High
Schizophrenia 5720 99.82 Very High Very High Very High
Aggression 52 99.32 Very High Very High Very High
Congenital Anomalies 1186 99.16 Very High Very High Very High
Psychosis 182 98.78 Very High Very High Very High
Panic Disorder 101 98.00 Very High Very High Very High
Cholangitis 12 97.92 Very High Very High Very High
Urological Neuroanatomy 104 97.48 Very High Very High Very High
Body Weight 46 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The serum levels of the parent drug and BPA do not result in particularly elevated peaks.
Gene_expression (levels) of BPA
1) Confidence 0.51 Published 1986 Journal Pharmatherapeutica Section Abstract Doc Link 3515370 Disease Relevance 0.86 Pain Relevance 0.49
Humans are exposed to BPA when it leaks from plastic packaging and dental appliances (Feldman 1997), and nanomolar concentrations have been measured in human serum (Takeuchi and Tsutsumi 2002).
Gene_expression (exposed) of BPA
2) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.26 Pain Relevance 0
When exposing pregnant mice to 100 mg/kg BPA given subcutaneously, BPA was detected 30 min after exposure in fetal sera, liver, brain uterus, and testes (Domoradzki et al. 2003; Shin et al. 2002; Uchida et al. 2002).
Gene_expression (exposing) of BPA in brain
3) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.06 Pain Relevance 0
It should be noted, however, that in our model the BPA effect had a more transient nature than did that of the other hormones.
Gene_expression (effect) of BPA
4) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0 Pain Relevance 0
In the present study, BPA was found to significantly induce luciferase activity at doses of 1,000 and 10,000 ?
Gene_expression (found) of BPA
5) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0 Pain Relevance 0.03
BPA has been found to possess weak estrogenic properties in in vitro assays with an EC50 (median effective concentration) about 10,000 times less than strong estrogens such as 17?
Gene_expression (found) of BPA
6) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.37 Pain Relevance 0
BPA has been found to possess weak estrogenic properties in in vitro assays with an EC50 (median effective concentration) about 10,000 times less than strong estrogens such as 17?
Gene_expression (possess) of BPA
7) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.37 Pain Relevance 0
When considering that nanomolar levels of BPA have been measured in human serum (Takeuchi and Tsutsumi 2002), human amniotic fluid at 15–18 weeks of gestation (Ikezuki et al. 2002), and surface water (Fromme et al. 2003), concern about BPA exposure during embryonic/fetal life seems to be justified.
Gene_expression (exposure) of BPA in amniotic fluid
8) Confidence 0.41 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0 Pain Relevance 0
Levels of BPA in amniotic fluid at 15–18 weeks of gestation have been shown to be 5-fold higher than serum levels in both pregnant and nonpregnant women, suggesting a possible accumulation of BPA in the early embryo (Ikezuki et al. 2002), although Domoradzki et al. (2003) could not confirm this in animal experiments.
Gene_expression (Levels) of BPA in amniotic fluid
9) Confidence 0.37 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.42 Pain Relevance 0.03
When exposing pregnant mice to 100 mg/kg BPA given subcutaneously, BPA was detected 30 min after exposure in fetal sera, liver, brain uterus, and testes (Domoradzki et al. 2003; Shin et al. 2002; Uchida et al. 2002).
Gene_expression (detected) of BPA in brain
10) Confidence 0.37 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247619 Disease Relevance 0.06 Pain Relevance 0
Perinatal BPA exposure did not alter the uterine response to E2 administered from PND25 to PND35 in either mouse strain.
Gene_expression (exposure) of BPA in uterine associated with sprains and strains
11) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.46 Pain Relevance 0
Consistent with this concept, previous studies of CD-1 mice exposed perinatally to BPA revealed an increased number of TEBs at puberty and terminal ends in adulthood (Markey et al. 2001a; Munoz de Toro et al. 2005).
Gene_expression (exposed) of BPA
12) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.39 Pain Relevance 0
In contrast, the response of the mammary gland to E2 was significantly altered by perinatal BPA exposure.
Gene_expression (exposure) of BPA in mammary gland
13) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.44 Pain Relevance 0
Also, there is an overexpression of progesterone receptors in BPA-exposed animals, which in turn induces excessive lateral branching of the mammary gland ducts (Munoz de Toro et al. 2005), resulting in an increased ductal density of the gland.
Gene_expression (overexpression) of BPA in gland
14) Confidence 0.33 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1852652 Disease Relevance 0.43 Pain Relevance 0
As mentioned previously, BDNF and DA neurotransmission appear linked in schizophrenia.181 Increased BDNF associated with hyperactive glutamatergic neurons has been found in cerebellar granule cells in schizophrenia.244 Another study of schizophrenia found reduced plasma levels of BDNF in first-episode psychosis compared with normal.245 In mouse cerebellar granule cells, BPA decreases induction of both BDNF and c-fos mRNA.246 These results are difficult to interpret as induction of c-fos may be altered in similar directions by amphetamine, PCP, and antipsychotic treatment depending on brain region, dose, timing, and environment.247–250

cAMP-Responsive Element-Binding Protein and Mitogen-Activated Protein.

Gene_expression (induction) of BPA in glutamatergic neurons associated with dopamine, psychosis and schizophrenia
15) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 1.18 Pain Relevance 0.09
For example, female but not male rats prenatally and/or perinatally exposed to BPA exhibit increased neophobia.309 Female Mongolian gerbils exposed to varying levels of BPA display decreased exploratory behaviors,315 and perinatal BPA exposure of mice results in the decrease or elimination of sexual differences exhibited by mice in exploration and emotional response tests.316 Male rat offspring exposed prenatally to BPA exhibit greater aggression before but not after puberty.317
Gene_expression (exposure) of BPA associated with aggression
16) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.56 Pain Relevance 0.29
For example, female but not male rats prenatally and/or perinatally exposed to BPA exhibit increased neophobia.309 Female Mongolian gerbils exposed to varying levels of BPA display decreased exploratory behaviors,315 and perinatal BPA exposure of mice results in the decrease or elimination of sexual differences exhibited by mice in exploration and emotional response tests.316 Male rat offspring exposed prenatally to BPA exhibit greater aggression before but not after puberty.317
Gene_expression (levels) of BPA associated with aggression
17) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.63 Pain Relevance 0.40
For example, female but not male rats prenatally and/or perinatally exposed to BPA exhibit increased neophobia.309 Female Mongolian gerbils exposed to varying levels of BPA display decreased exploratory behaviors,315 and perinatal BPA exposure of mice results in the decrease or elimination of sexual differences exhibited by mice in exploration and emotional response tests.316 Male rat offspring exposed prenatally to BPA exhibit greater aggression before but not after puberty.317
Gene_expression (exposed) of BPA associated with aggression
18) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.43 Pain Relevance 0.21
BPA increases antibody response to protein antigens in vivo292 and enhances autoantibody production by B1 cells that may influence the development of autoimmune diseases.293 Th1 greater than Th2 cytokine induction is nearly universal in immunological studies of mice exposed to BPA tending to support an autoimmune response.294–298 One study found BPA exposure suppressed the Th-2 (IL-4) response.299 Another found that BPA impairs lymphocyte proliferation.295
Gene_expression (exposure) of BPA in lymphocyte associated with autoimmune disease and cytokine
19) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.82 Pain Relevance 0.05
This review summarizes these findings and proposes a theory of endocrine disruption, like that observed from BPA exposure, as a pathway of schizophrenia pathogenesis.
Gene_expression (exposure) of BPA associated with schizophrenia
20) Confidence 0.28 Published 2009 Journal Schizophrenia Bulletin Section Abstract Doc Link PMC2643957 Disease Relevance 1.05 Pain Relevance 0.04

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