INT3735

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Context Info
Confidence 0.73
First Reported 1977
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 3.83
Pain Relevance 2.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on glycosyl bonds (Neu1) plasma membrane (Neu1) lysosome (Neu1)
Anatomy Link Frequency
neutrophils 5
lymph nodes 1
Neu1 (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 5 99.32 Very High Very High Very High
Inflammation 12 97.76 Very High Very High Very High
rheumatoid arthritis 99 96.96 Very High Very High Very High
cINOD 9 96.88 Very High Very High Very High
spinal inflammation 55 96.40 Very High Very High Very High
Analgesic 2 87.08 High High
Infliximab 81 86.64 High High
Osteoarthritis 2 75.00 Quite High
methotrexate 9 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 100.00 Very High Very High Very High
Hypersensitivity 1 99.08 Very High Very High Very High
Cancer 23 98.36 Very High Very High Very High
INFLAMMATION 21 97.76 Very High Very High Very High
Rheumatoid Arthritis 99 96.96 Very High Very High Very High
Low Back Pain 55 96.40 Very High Very High Very High
Osteoarthritis 4 92.96 High High
Arthritis 2 80.72 Quite High
Recurrence 23 75.92 Quite High
Breast Cancer 38 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Occurrence of aPL/ACL and anti-?
Localization (Occurrence) of aPL
1) Confidence 0.73 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064868 Disease Relevance 1.64 Pain Relevance 1.26
While the sequential administration of trastuzumab after chemotherapy appears to be effective, longer follow- up is needed to determine whether simultaneous and sequential administration with other chemotherapy agents are equally effective and whether there is a population of patients in whom chemotherapy is not necessary (patients with estrogen receptor-positive and HER-2/neu-positive disease, patients with negative lymph nodes and tumors < 1 cm) and for whom trastuzumab alone might represent appropriate adjuvant therapy.
Localization (disease) of neu-positive in lymph nodes associated with cancer and disease
2) Confidence 0.12 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1959236 Disease Relevance 0.46 Pain Relevance 0
Mean concentrations in both groups correlated strongly with the level of beta-glucuronidase activity as a measure of lysosomal enzyme release (r = 0.71, p less than 0.0001).
Localization (release) of lysosomal enzyme
3) Confidence 0.04 Published 1987 Journal Clin. Chim. Acta Section Abstract Doc Link 3594915 Disease Relevance 0.50 Pain Relevance 0.23
Anti-inflammatory activity of the nonsteroidal anti-inflammatory drugs has been ascribed to prostaglandin synthesis inhibition; recent studies suggest additional effects based on inhibition of neutrophil aggregation, superoxide radical generation, and lysosomal enzyme release.
Localization (release) of lysosomal enzyme in neutrophil associated with inflammation and cinod
4) Confidence 0.01 Published 1985 Journal Am. J. Med. Section Abstract Doc Link 3904439 Disease Relevance 0.83 Pain Relevance 0.60
PGF2alpha accelerated lysosomal enzyme release, had no effect on phagocytosis at high concentrations and inhibited both processes at low concentrations..
Localization (release) of lysosomal enzyme
5) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.04
Naproxen, chloroquine and indomethacin inhibited particle uptake by and lysosomal enzyme secretion from neutrophils incubated with zymosan in Krebs-Ringer phosphate medium, pH 7.4, at 37 degrees C.
Localization (secretion) of lysosomal enzyme in neutrophils
6) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.04
In the presence of cytochalasin B, an agent which inhibits phagocytosis while havine no effect on selective lysosomal enzyme secretion, naproxen, chloroquine and indomethacin, continued to inhibit the discharge of beta-glucuronidase from neutrophils.
Localization (secretion) of lysosomal enzyme in neutrophils
7) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.09
Modulation of phagocytosis by and lysosomal enzyme secretion from guinea-pig neutrophils: effect of nonsteroid anti-inflammatory agents and prostaglindins.
Localization (secretion) of lysosomal enzyme in neutrophils associated with aspirin and inflammation
8) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 850132 Disease Relevance 0.10 Pain Relevance 0.10
PGE1, PGE2, PGA1, PGA2, PGB1 and PGB2 reduced lysosomal enzyme release from cytochalasin B-treated neutrophils.
Localization (release) of lysosomal enzyme in neutrophils
9) Confidence 0.00 Published 1977 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 850132 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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