INT37350

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.15
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (ENPEP) peptidase activity (ENPEP) cell-cell signaling (ENPEP)
Anatomy Link Frequency
plasma 1
osteoblasts 1
urine 1
ENPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 21 100.00 Very High Very High Very High
Bioavailability 2 84.24 Quite High
Pain 21 76.76 Quite High
antidepressant 2 64.24 Quite High
sSRI 2 63.56 Quite High
substance P 2 60.96 Quite High
Triptan 2 60.76 Quite High
antagonist 4 58.56 Quite High
Serotonin 2 57.44 Quite High
agonist 2 56.68 Quite High
Disease Link Frequency Relevance Heat
Phosphate Metabolism Disorders 55 98.76 Very High Very High Very High
Bone Disease 73 97.44 Very High Very High Very High
Congenital Anomalies 5 96.72 Very High Very High Very High
Osteogenic Sarcomas 10 80.84 Quite High
Pain 20 76.76 Quite High
Disease 15 71.84 Quite High
Cluster Headache 2 61.60 Quite High
Osteoarthritis 2 50.00 Quite Low
Hyperplasia 1 41.52 Quite Low
INFLAMMATION 8 18.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results emphasize the selective nature of chemical structures required to significantly inhibit AP activity and provided information that could help the rational design of agents with high specificity in a biologic milieu containing multiple peptidases.
Negative_regulation (inhibit) of AP
1) Confidence 0.42 Published 2004 Journal Am J Ther Section Abstract Doc Link 15543085 Disease Relevance 0.05 Pain Relevance 0.78
Inhibition of human plasma leucine5-enkephalin aminopeptidase hydrolysis by various endogenous peptides and a select number of clinically used drugs.
Negative_regulation (Inhibition) of aminopeptidase in plasma associated with enkephalin
2) Confidence 0.36 Published 2004 Journal Am J Ther Section Title Doc Link 15543085 Disease Relevance 0.06 Pain Relevance 0.68
LTB(4) dose-dependently inhibited AP activity in OA osteoblasts, while its effect on osteocalcin depended on endogenous LTB(4) levels in these cells.
Negative_regulation (inhibited) of AP in osteoblasts
3) Confidence 0.17 Published 2002 Journal Arthritis Rheum. Section Body Doc Link 12124864 Disease Relevance 0 Pain Relevance 0
Regardless of the differently worded position statements of the APA and A?
Negative_regulation (worded) of APA
4) Confidence 0.14 Published 2008 Journal Philos Ethics Humanit Med Section Body Doc Link PMC2561033 Disease Relevance 0 Pain Relevance 0
These compounds are effective inhibitors of human enkephalin degrading aminopeptidase, microsomal leucine aminopeptidase (EC 3.4.11.2), and cytosolic leucine aminopeptidase (EC 3.4.11.1) at micro- to nanomolar concentrations.
Negative_regulation (inhibitors) of enkephalin degrading aminopeptidase associated with enkephalin
5) Confidence 0.06 Published 1986 Journal Biochemistry Section Abstract Doc Link 3516217 Disease Relevance 0 Pain Relevance 0.10
Evaluation of AP, measured by an autoanalyzer, has been performed also in all the individuals undergoing mutational analysis.
Negative_regulation (Evaluation) of AP
6) Confidence 0.05 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297578 Disease Relevance 0.94 Pain Relevance 0.14
The diagnosis of childhood HP was based on clinical signs and confirmed in all patients by reduced serum alkaline phosphatase (AP) activity and elevated AP substrate, including phosphoethanolamine (PEA), levels in urine and elevated pyridoxal-5'-phosphate (PLP) in plasma [21].
Negative_regulation (reduced) of AP in urine associated with phosphate metabolism disorders
7) Confidence 0.04 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1533806 Disease Relevance 0.10 Pain Relevance 0

General Comments

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