INT37364

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Context Info
Confidence 0.29
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.50
Pain Relevance 0.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
osteoclast 1
Oaf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 131 99.84 Very High Very High Very High
Visceral pain 15 91.76 High High
analgesia 20 89.60 High High
Opioid 12 87.44 High High
Pain 15 82.84 Quite High
antagonist 37 78.96 Quite High
Analgesic 16 74.80 Quite High
Enkephalin 6 56.80 Quite High
agonist 11 29.12 Quite Low
Antinociceptive 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 1 97.88 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

15 91.76 High High
Pain 12 82.84 Quite High
Multiple Myeloma 2 81.64 Quite High
Osteoporosis 1 75.00 Quite High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

32 5.00 Very Low Very Low Very Low
Nociception 7 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Colitis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The demonstration of increased osteoclast activating factor (OAF) derived from the cultured myeloma cells from each case suggests that the secretion of OAF and immunoglobulin are unrelated.
Positive_regulation (increased) of OAF in osteoclast
1) Confidence 0.29 Published 1986 Journal Am. J. Med. Sci. Section Abstract Doc Link 3518452 Disease Relevance 0.41 Pain Relevance 0.08
Similar transactivation of opioid receptors by epidermal growth factor receptor has been recently described [44], however this is the first evidence of transactivation of MOR by activation of KATP channels.


Positive_regulation (transactivation) of first associated with opioid receptor
2) Confidence 0.02 Published 2010 Journal Mol Pain Section Body Doc Link PMC2908066 Disease Relevance 0 Pain Relevance 0.86

General Comments

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