INT37377

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Context Info
Confidence 0.38
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 1.79
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mme) plasma membrane (Mme)
Anatomy Link Frequency
plasma 4
lungs 4
Mme (Mus musculus)
Pain Link Frequency Relevance Heat
Antinociceptive 3 99.46 Very High Very High Very High
narcan 7 98.60 Very High Very High Very High
opiate 1 98.08 Very High Very High Very High
antagonist 1 97.44 Very High Very High Very High
Inflammation 28 97.00 Very High Very High Very High
Analgesic 2 95.92 Very High Very High Very High
Enkephalin 3 75.00 Quite High
withdrawal 1 59.12 Quite High
tail-flick 1 56.64 Quite High
Morphine 2 52.96 Quite High
Disease Link Frequency Relevance Heat
Adult Respiratory Distress Syndrome 352 99.68 Very High Very High Very High
INFLAMMATION 32 97.00 Very High Very High Very High
Sepsis 8 87.84 High High
Nociception 2 75.00 Quite High
Respiratory Disease 4 60.88 Quite High
Pressure And Volume Under Development 8 44.40 Quite Low
Lung Injury 52 22.12 Low Low
Pulmonary Edema 8 21.32 Low Low
Injury 56 20.00 Low Low
Leukemia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The measurements made with this sensitive method indicated that the activity of NEP in plasma was decreased during ALI.
Negative_regulation (decreased) of NEP Binding (activity) of in plasma associated with adult respiratory distress syndrome
1) Confidence 0.38 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 1.15 Pain Relevance 0.03
Decreased lung NEP activity in mice with acute lung injury
Negative_regulation (Decreased) of NEP Binding (activity) of in lung associated with adult respiratory distress syndrome
2) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.30 Pain Relevance 0.03
Decreased plasma NEP activity in mice with acute lung injury
Negative_regulation (Decreased) of NEP Binding (activity) of in plasma associated with adult respiratory distress syndrome
3) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0.27 Pain Relevance 0.05
For measurements of NEP activity in mouse lungs, each specimen was homogenized with 5 volumes of 50 mM homogenate HEPES buffer at pH 7.4, containing 1 mM ethylene glycol tetraacetic acid, 50 ?
Negative_regulation (measurements) of NEP Binding (activity) of in lungs
4) Confidence 0.37 Published 2010 Journal Respir Res Section Body Doc Link PMC3009633 Disease Relevance 0 Pain Relevance 0
The antinociceptive effects of Thiorphan, an 'enkephalinase' inhibitor, or bestatin, an aminopeptidase inhibitor, as well as of their association and the pronociceptive effects of naloxone, an opiate receptor antagonist, were evaluated in various analgesic tests in mice.
Negative_regulation (inhibitor) of enkephalinase Binding (association) of associated with analgesic, antagonist, narcan, opiate and antinociceptive
5) Confidence 0.24 Published 1986 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3519246 Disease Relevance 0.07 Pain Relevance 0.76

General Comments

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