INT37379

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Context Info
Confidence 0.62
First Reported 1984
Last Reported 2002
Negated 1
Speculated 1
Reported most in Abstract
Documents 10
Total Number 12
Disease Relevance 0.16
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Glp1r) signal transducer activity (Glp1r)
Anatomy Link Frequency
ileum 4
colon 2
intestines 2
Glp1r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 12 100.00 Very High Very High Very High
Neuropeptide 6 100.00 Very High Very High Very High
qutenza 6 100.00 Very High Very High Very High
narcan 2 100.00 Very High Very High Very High
Somatostatin 17 99.88 Very High Very High Very High
Neurotransmitter 12 99.84 Very High Very High Very High
tetrodotoxin 5 99.82 Very High Very High Very High
Cholecystokinin 3 98.88 Very High Very High Very High
opiate 7 98.40 Very High Very High Very High
Opioid 11 96.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 1 80.72 Quite High
Stress 1 76.84 Quite High
Diabetes Mellitus 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Regulation of glucagon-like peptide-1 secretion from rat ileum by neurotransmitters and peptides.
Regulation (Regulation) of Localization (secretion) of glucagon-like peptide-1 in ileum associated with neurotransmitter and neuropeptide
1) Confidence 0.62 Published 1995 Journal J. Endocrinol. Section Title Doc Link 7490533 Disease Relevance 0 Pain Relevance 0.34
Paradoxically, GLP-1 originates from the lower intestines and therefore a complex regulation of postprandial GLP-1 secretion must exist.
Regulation (regulation) of Localization (secretion) of GLP-1 in intestines
2) Confidence 0.62 Published 1995 Journal J. Endocrinol. Section Abstract Doc Link 7490533 Disease Relevance 0 Pain Relevance 0.23
These results demonstrate the role of M1 muscarinic receptors expressed by L cells in the control of postprandial secretion of GLP-1.
Regulation (control) of Localization (secretion) of GLP-1
3) Confidence 0.62 Published 2002 Journal Endocrinology Section Abstract Doc Link 12021207 Disease Relevance 0 Pain Relevance 0.16
M2 muscarinic receptors also seem to play a role in controlling GLP-1 secretion by fetal, but not adult, L cells.
Regulation (controlling) of Localization (secretion) of GLP-1
4) Confidence 0.62 Published 2002 Journal Endocrinology Section Abstract Doc Link 12021207 Disease Relevance 0 Pain Relevance 0.16
Additionally, GLP-1 and PYY secretions are positively modulated by alpha1-receptor stimulation and inhibited by alpha2-receptor activation upon beta-receptor occupation.
Regulation (modulated) of Localization (secretions) of GLP-1
5) Confidence 0.60 Published 1999 Journal J. Endocrinol. Section Abstract Doc Link 10425466 Disease Relevance 0 Pain Relevance 0.23
Tetrodotoxin did not modify the GIP-induced release of GLP-1.
Neg (not) Regulation (modify) of Localization (release) of GLP-1 associated with tetrodotoxin
6) Confidence 0.27 Published 1994 Journal Endocrinology Section Abstract Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.30
Regulation of glucagon-like peptide-1-(7-36) amide secretion by intestinal neurotransmitters and hormones in the isolated vascularly perfused rat colon.
Regulation (Regulation) of Localization (secretion) of glucagon-like peptide-1 in colon associated with neurotransmitter and neuropeptide
7) Confidence 0.24 Published 1994 Journal Endocrinology Section Title Doc Link 7988423 Disease Relevance 0 Pain Relevance 0.26
Regulation of glucagon-like peptide-1-(7-36) amide, peptide YY, and neurotensin secretion by neurotransmitters and gut hormones in the isolated vascularly perfused rat ileum.
Regulation (Regulation) of Localization (secretion) of glucagon-like peptide-1 in ileum associated with neurotransmitter
8) Confidence 0.23 Published 1995 Journal Endocrinology Section Title Doc Link 7588257 Disease Relevance 0 Pain Relevance 0.11
The effects of infusion of the two tachykinins, substance P (SP) and neurokinin A (NKA), and of capsaicin on the release of glucagon-like peptide-1 (GLP-1), somatostatin, and vasoactive intestinal polypeptide (VIP) were studied in isolated, vascularly perfused ileal segments.
Regulation (effects) of Localization (release) of GLP-1 associated with qutenza, somatostatin and substance p
9) Confidence 0.10 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489905 Disease Relevance 0 Pain Relevance 0.56
The effects of infusion of the two tachykinins, substance P (SP) and neurokinin A (NKA), and of capsaicin on the release of glucagon-like peptide-1 (GLP-1), somatostatin, and vasoactive intestinal polypeptide (VIP) were studied in isolated, vascularly perfused ileal segments.
Regulation (effects) of Localization (release) of glucagon-like peptide-1 associated with qutenza, somatostatin and substance p
10) Confidence 0.07 Published 1999 Journal Dig. Dis. Sci. Section Abstract Doc Link 10489905 Disease Relevance 0 Pain Relevance 0.56
To determine the effects of nutrients on pancreatic hormone release, intravenous arginine or oral glucose were administered to the animals of the three experimental groups.
Spec (determine) Regulation (effects) of Localization (release) of pancreatic hormone
11) Confidence 0.02 Published 1986 Journal Horm. Metab. Res. Section Abstract Doc Link 3519410 Disease Relevance 0.08 Pain Relevance 0.09
An effect of naloxone on pancreatic hormone release was observed after meals which contain opiate active substance.
Regulation (effect) of Localization (release) of pancreatic hormone associated with narcan and opiate
12) Confidence 0.01 Published 1984 Journal Horm. Metab. Res. Section Abstract Doc Link 6088380 Disease Relevance 0.08 Pain Relevance 1.30

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