INT3738

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Context Info
Confidence 0.61
First Reported 1977
Last Reported 2010
Negated 5
Speculated 6
Reported most in Abstract
Documents 25
Total Number 32
Disease Relevance 13.73
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Epo) aging (Epo) extracellular region (Epo)
Anatomy Link Frequency
liver 2
urine 2
macrophage 1
plasma 1
brain 1
Epo (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 14 100.00 Very High Very High Very High
acular 8 100.00 Very High Very High Very High
Analgesic 3 100.00 Very High Very High Very High
Pain 8 99.98 Very High Very High Very High
Dismenorea 5 99.12 Very High Very High Very High
agonist 1 98.96 Very High Very High Very High
local anesthetic 2 98.92 Very High Very High Very High
Clonidine 2 97.80 Very High Very High Very High
ischemia 114 97.20 Very High Very High Very High
anesthesia 26 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 7 99.98 Very High Very High Very High
Sepsis 79 99.96 Very High Very High Very High
Stroke 44 99.92 Very High Very High Very High
Congenital Anomalies 2 99.80 Very High Very High Very High
Uremia 2 99.68 Very High Very High Very High
Small Cell Lung Cancer 7 99.44 Very High Very High Very High
Altitude Sickness 2 99.44 Very High Very High Very High
Reprotox - General 1 3 99.12 Very High Very High Very High
Anaemia 26 99.04 Very High Very High Very High
Nicotine Addiction 1 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EPO is required for normal brain development and regulates neurogenesis and glial cell proliferation in the adult mouse brain (Shingo et al., 2001; Sugawa et al., 2002), whereas stroke up-regulates endogenous EPO and its receptor (Bernaudin et al., 1999).
Regulation (regulates) of EPO in adult mouse associated with stroke and neurodegenerative disease
1) Confidence 0.61 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.48 Pain Relevance 0.04
Effects of ketorolac tromethamine on erythropoietin levels in Sprague Dawley rats.
Regulation (Effects) of erythropoietin associated with analgesic and acular
2) Confidence 0.57 Published 1994 Journal Int J Artif Organs Section Title Doc Link 7759142 Disease Relevance 0.15 Pain Relevance 0.59
Several solutions to the processes of anemia, such as blunted erythropoietin production and erythropoietin response and abnormalities in iron metabolism have been developed.
Regulation (response) of erythropoietin associated with anaemia and congenital anomalies
3) Confidence 0.47 Published 2004 Journal Crit Care Clin Section Abstract Doc Link 15135458 Disease Relevance 1.01 Pain Relevance 0
We investigated the effect of RD administered to rats in the last day of gestation on the dam and the fetuses' levels of EPO.
Spec (investigated) Regulation (effect) of EPO
4) Confidence 0.45 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.19 Pain Relevance 0.19
Furthermore, we also evaluated whether EPO administration affects the expansion of the SVZ in response to a hypoxic- ischemic insult to the neonatal brain, by a volumetric analysis of SVZ of the rat brain.


Spec (whether) Regulation (affects) of EPO in brain associated with hypoxia
5) Confidence 0.45 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526527 Disease Relevance 1.04 Pain Relevance 0.19
This study was designed to investigate the effects of erythropoietin (EPO) treatment after unilateral testicular torsion.
Spec (investigate) Regulation (effects) of EPO associated with spermatic cord torsion
6) Confidence 0.45 Published 2007 Journal World J Urol Section Abstract Doc Link 17690891 Disease Relevance 0.36 Pain Relevance 0.13
This study was designed to investigate the effects of erythropoietin (EPO) treatment after unilateral testicular torsion.
Spec (investigate) Regulation (effects) of erythropoietin associated with spermatic cord torsion
7) Confidence 0.45 Published 2007 Journal World J Urol Section Abstract Doc Link 17690891 Disease Relevance 0.36 Pain Relevance 0.13
No direct effects of rhEPO administration on the emergence of active oxygen were observed.
Neg (No) Regulation (effects) of rhEPO
8) Confidence 0.45 Published 2010 Journal Hinyokika Kiyo Section Abstract Doc Link 20808070 Disease Relevance 0.42 Pain Relevance 0.10
The above mentioned experimental evidences prompted us to compare the effects of the administration of rhEPO, GM-CSF and their combination on liver regeneration following major hepatectomy.
Regulation (effects) of rhEPO in liver
9) Confidence 0.45 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.36 Pain Relevance 0.12
Aim of the present study is to compare the effect of the administration of EPO and GM-CSF alone or in combination on the acceleration of liver regeneration in rats after major hepatectomy.


Regulation (effect) of EPO in liver
10) Confidence 0.45 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2917416 Disease Relevance 0.20 Pain Relevance 0.14
As a prelude to an investigation of the possible use of local anesthetics as additives to subcutaneous rHuEPO, we examined the effect of the addition of lidocaine on the erythropoietic properties of rHuEPO.
Spec (examined) Regulation (effect) of rHuEPO associated with lidocaine and local anesthetic
11) Confidence 0.44 Published 1994 Journal Pediatr. Nephrol. Section Abstract Doc Link 7947041 Disease Relevance 0.17 Pain Relevance 0.75
Effect of lidocaine on the hematopoietic properties of recombinant human erythropoietin in the uremic rat.
Regulation (Effect) of erythropoietin associated with lidocaine and uremia
12) Confidence 0.44 Published 1994 Journal Pediatr. Nephrol. Section Title Doc Link 7947041 Disease Relevance 0.20 Pain Relevance 0.74
Effects of oxygen inhalation on endogenous erythropoietin kinetics, erythropoiesis, and properties of blood cells in sickle-cell anemia.
Regulation (Effects) of erythropoietin in blood cells associated with anaemia
13) Confidence 0.44 Published 1984 Journal N. Engl. J. Med. Section Title Doc Link 6738642 Disease Relevance 0.35 Pain Relevance 0.05
The mechanism associated with EPO expression regulation and G-CSF in the present study may be similar to a previously described molecular mechanism involved in VEGF expression regulation and macrophage colony-stimulating factor (M-CSF) in cell monocytes and macrophages [29].
Regulation (regulation) of EPO in macrophage
14) Confidence 0.39 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2852409 Disease Relevance 0.30 Pain Relevance 0.06
The data in the present study has demonstrated that systemic administration of r-Hu-EPO is also effective in stimulating the proliferative potentials of progenitor cells in the ischemic penumbra and SVZ of LV in a similar fashion to intracerebro-ventriculaly administered EPO.
Regulation (effective) of r-Hu-EPO
15) Confidence 0.39 Published 2010 Journal Anatomy & Cell Biology Section Body Doc Link PMC2998786 Disease Relevance 0.35 Pain Relevance 0.07
Very preliminary analysis of an ongoing phase III trial studying two erythropoietin doses given continuously subcutaneously versus a retrospective analysis of a "control group" (drawn from historical data on the occurrence of anemia in cisplatin- and/or carboplatin-treated patients) has shown beneficial effects of erythropoietin during treatment with these platinating agents.
Regulation (effects) of erythropoietin associated with anaemia
16) Confidence 0.39 Published 1994 Journal Semin. Oncol. Section Abstract Doc Link 8202718 Disease Relevance 0.47 Pain Relevance 0.11
Subsequent studies found similar effects of EGF and EPO treatments on more posterior injuries.
Regulation (effects) of EPO in posterior associated with injury
17) Confidence 0.37 Published 2010 Journal Frontiers in Human Neuroscience Section Body Doc Link PMC2991189 Disease Relevance 0.24 Pain Relevance 0
We examined the effect of dietary supplementation with L-arginine on breath condensate VEGF, exhaled nitric oxide (NO), plasma erythropoietin, symptoms of acute mountain sickness, and respiratory related sensations at 4,342 m through the course of 24 h in seven healthy male subjects.
Spec (examined) Regulation (effect) of erythropoietin in respiratory associated with altitude sickness
18) Confidence 0.30 Published 2005 Journal High Alt. Med. Biol. Section Abstract Doc Link 16351563 Disease Relevance 0.24 Pain Relevance 0.14
The data show that acute administration of ritodrine reduces fetal and dam plasma EPO, while long-term terbutaline treatment late in gestation alters maternal, but not fetal plasma EPO, indicating that neither drug has any direct regulatory effect on the erythropoietic ability of the fetuses.
Regulation (alters) of EPO in plasma
19) Confidence 0.27 Published 1994 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 7993659 Disease Relevance 0.11 Pain Relevance 0.12
Regional wall thickening in the infarct border zone was significantly higher in rats that received eEPCs + EPO compared to eEPC, EPO alone or controls (Fig. 3B).
Regulation (controls) of EPO in thickening
20) Confidence 0.27 Published 2010 Journal BMC Cardiovasc Disord Section Body Doc Link PMC2954875 Disease Relevance 0.07 Pain Relevance 0.04

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