INT37380

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Context Info
Confidence 0.55
First Reported 1980
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 31
Total Number 32
Disease Relevance 19.89
Pain Relevance 3.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
shoulder 2
bowel 2
glenoid fossa 1
small intestine 1
intestine 1
Sis (Mus musculus)
Pain Link Frequency Relevance Heat
shoulder pain 17 99.30 Very High Very High Very High
Sciatic nerve 6 98.84 Very High Very High Very High
abdominal pain 11 98.78 Very High Very High Very High
induced neuropathy 6 98.40 Very High Very High Very High
Inflammation 8 98.28 Very High Very High Very High
tolerance 7 98.16 Very High Very High Very High
Morphine 1 96.56 Very High Very High Very High
Pain 36 95.20 Very High Very High Very High
Angina 2 91.36 High High
cINOD 3 90.68 High High
Disease Link Frequency Relevance Heat
Shoulder Impingement Syndrome 119 100.00 Very High Very High Very High
Glucose Metabolism Disorders 2 100.00 Very High Very High Very High
Diarrhoea 53 99.68 Very High Very High Very High
Diabetes Mellitus 152 99.60 Very High Very High Very High
Shoulder Pain 17 99.30 Very High Very High Very High
Obesity 13 99.24 Very High Very High Very High
Disorder Of Lipid Metabolism 7 99.14 Very High Very High Very High
Impaired Glucose Tolerance 3 98.80 Very High Very High Very High
Abdominal Pain 11 98.78 Very High Very High Very High
Aging 3 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cadmium ions inhibited the activity of the neutral alpha-glucosidase by a maximum of 24.0%, while acid alpha-glucosidase was not inhibited.
Negative_regulation (inhibited) of alpha-glucosidase
1) Confidence 0.55 Published 1981 Journal Neurotoxicology Section Abstract Doc Link 15622722 Disease Relevance 0.25 Pain Relevance 0.25
Eighty-one breath hydrogen tests were performed in 72 children who were investigated either because of chronic diarrhoea or recurrent abdominal pain, or because they were relatives of patients with congenital sucrase-isomaltase deficiency.
Negative_regulation (deficiency) of sucrase-isomaltase associated with abdominal pain and diarrhoea
2) Confidence 0.50 Published 1983 Journal Med. J. Aust. Section Abstract Doc Link 6865823 Disease Relevance 0.20 Pain Relevance 0.10
Cadmium ions inhibited the activity of the neutral alpha-glucosidase by a maximum of 24.0%, while acid alpha-glucosidase was not inhibited.
Negative_regulation (inhibited) of alpha-glucosidase
3) Confidence 0.48 Published 1981 Journal Neurotoxicology Section Abstract Doc Link 15622722 Disease Relevance 0.25 Pain Relevance 0.25
The results of tests on 16 patients were positive (sucrase-isomaltase deficiency, seven patients; secondary sucrose malabsorption, nine patients).
Negative_regulation (deficiency) of sucrase-isomaltase
4) Confidence 0.42 Published 1983 Journal Med. J. Aust. Section Abstract Doc Link 6865823 Disease Relevance 0.19 Pain Relevance 0.09
It was considered that the inhibitory effect of cadmium on the neutral alpha-glucosidase led to the enlargement of glycogen particles, and the large glycogen molecules were then engulfed in the lysosome system.
Negative_regulation (effect) of alpha-glucosidase
5) Confidence 0.41 Published 1981 Journal Neurotoxicology Section Abstract Doc Link 15622722 Disease Relevance 0.25 Pain Relevance 0.25
Sucrose malabsorption defined as an abnormal increase in expired hydrogen, was found in only 3 children who suffered from congenital sucrase-isomaltase deficiency.
Negative_regulation (deficiency) of sucrase-isomaltase
6) Confidence 0.40 Published 1980 Journal Acta Paediatr Scand Section Abstract Doc Link 7368916 Disease Relevance 0.28 Pain Relevance 0.24
We previously demonstrated that the steadiness of shoulder abduction is reduced in patients with subacromial impingement syndrome (SIS), which might be related to shoulder pain associated with the SIS.
Negative_regulation (reduced) of SIS in shoulder associated with shoulder impingement syndrome and shoulder pain
7) Confidence 0.37 Published 2008 Journal Eur. J. Appl. Physiol. Section Abstract Doc Link 18066578 Disease Relevance 0.67 Pain Relevance 0.37
Increased downward rotation of the glenoid fossa will reduce the size of the subacromial area and could contribute to the development or persistence of SIS, potentially accounting for the longevity and chronic nature of SIS in the clinical setting.
Negative_regulation (persistence) of SIS in glenoid fossa associated with aging and shoulder impingement syndrome
8) Confidence 0.36 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2846868 Disease Relevance 1.07 Pain Relevance 0.19
The inhibition of alpha-glucosidase by these agents is competitive and reversible and results in delayed and reduced uptake of carbohydrates across the intestine.
Negative_regulation (inhibition) of alpha-glucosidase in intestine
9) Confidence 0.33 Published 1995 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 8562269 Disease Relevance 0.64 Pain Relevance 0.06
[alpha-Glucosidase inhibitors in the therapy of diabetes mellitus].
Negative_regulation (inhibitors) of alpha-Glucosidase associated with diabetes mellitus
10) Confidence 0.24 Published 1995 Journal Ann. Ital. Med. Int. Section Title Doc Link 8562269 Disease Relevance 0.49 Pain Relevance 0
The compound acarbose is a member of first generation alpha-glucosidase inhibitors.
Negative_regulation (inhibitors) of alpha-glucosidase
11) Confidence 0.24 Published 1995 Journal Ann. Ital. Med. Int. Section Abstract Doc Link 8562269 Disease Relevance 0.84 Pain Relevance 0.09
Compared to their own baseline level, shoulder pain during reaching was significantly reduced in the SIS group and SISele subgroup during (mean difference: 0.3, P = 0.02), immediately after (respectively: 0.6 & 0.5, P < 0.004) and the day after training (respectively: 0.6 & 0.5, P < 0.004), while it remained unchanged in the SISdep subgroup.
Negative_regulation (reduced) of SIS in shoulder associated with shoulder impingement syndrome and shoulder pain
12) Confidence 0.24 Published 2009 Journal Sports Med Arthrosc Rehabil Ther Technol Section Body Doc Link PMC2694775 Disease Relevance 0.57 Pain Relevance 0.19
We report a case of pneumatosis intestinalis in a diabetic patient with minimal change nephrotic syndrome, receiving immunosuppressive drugs and an alpha-glucosidase inhibitor.
Negative_regulation (inhibitor) of alpha-glucosidase associated with diabetes mellitus and disorder of lipid metabolism
13) Confidence 0.18 Published 2007 Journal Intern. Med. Section Abstract Doc Link 17202732 Disease Relevance 0.52 Pain Relevance 0.13
Acarbose is an alpha-glucosidase inhibitor approved for the treatment of type 2 diabetes mellitus.
Negative_regulation (inhibitor) of alpha-glucosidase associated with diabetes mellitus
14) Confidence 0.16 Published 1998 Journal Clin Ther Section Abstract Doc Link 9663365 Disease Relevance 0.31 Pain Relevance 0.08
All enzyme activity is depressed significantly during the 9- to 21-week interval: alpha-glucosidase, beta-glucosidase, alpha-mannosidase, beta-galactosidase, acid phosphatase, N-acetyl-beta-galactosaminidase, 5'-phosphodiesterase type IV, and total rho-nitrophenyl phosphatase are reduced approximately 10 to 20 per cent, whereas beta-glucosaminidase, aryl sulfatase, and N-acetyl-beta-glucosaminidase are decreased almost 40 to 50 per cent.
Negative_regulation (reduced) of alpha-glucosidase
15) Confidence 0.16 Published 1980 Journal Lab. Invest. Section Abstract Doc Link 7421126 Disease Relevance 0.37 Pain Relevance 0.08
In addition, the activities of some intestinal mucosa enzymes (maltase, sucrase, lactase and alkaline phosphatase) in mice pretreated with extract before castor oil were not as severely depressed as those in the control (castor oil treated mice).
Neg (not) Negative_regulation (depressed) of sucrase
16) Confidence 0.14 Published 2000 Journal Afr J Med Med Sci Section Abstract Doc Link 11379441 Disease Relevance 0.18 Pain Relevance 0.10
Correlations between PRISM-RII (IPM and SIS) and other variables are presented in Table 2.
Negative_regulation (presented) of SIS
17) Confidence 0.13 Published 2008 Journal Health Qual Life Outcomes Section Body Doc Link PMC2627820 Disease Relevance 0.80 Pain Relevance 0
In elderly patients with NIDDM, a history of abdominal surgery and the amount of daily exercise must be considered when deciding whether or not to give alpha-glucosidase inhibitors.
Spec (whether) Negative_regulation (inhibitors) of alpha-glucosidase associated with diabetes mellitus
18) Confidence 0.10 Published 1996 Journal Nippon Ronen Igakkai Zasshi Section Abstract Doc Link 8921700 Disease Relevance 1.02 Pain Relevance 0.16
On the other hand, METh inhibited alpha-glucosidase activity in vitro, in a concentration-dependent manner (IC(50) of 3.16mg/mL).
Negative_regulation (inhibited) of alpha-glucosidase
19) Confidence 0.06 Published 2007 Journal J Ethnopharmacol Section Abstract Doc Link 16920301 Disease Relevance 0.56 Pain Relevance 0.12
At high glucose, however, a partial inhibition of both insulin release (approximately 50%) and acid alpha-glucosidase activity was seen. 2-Deoxyglucose slightly suppressed acid phosphatase activity but did not influence the activities of neutral alpha-glucosidase or N-acetyl-beta-D- glucosaminidase.
Negative_regulation (inhibition) of alpha-glucosidase
20) Confidence 0.05 Published 1993 Journal Pharmacology Section Abstract Doc Link 8441762 Disease Relevance 0 Pain Relevance 0.07

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