INT37390

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Context Info
Confidence 0.46
First Reported 1986
Last Reported 2010
Negated 5
Speculated 8
Reported most in Abstract
Documents 39
Total Number 47
Disease Relevance 28.74
Pain Relevance 11.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crp) extracellular region (Crp)
Anatomy Link Frequency
leukocyte 7
coronary artery 3
platelet 2
blood 2
joints 2
Crp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory marker 133 100.00 Very High Very High Very High
Pain 32 100.00 Very High Very High Very High
antagonist 11 100.00 Very High Very High Very High
Perioperative pain 7 99.96 Very High Very High Very High
cINOD 30 99.84 Very High Very High Very High
Inflammation 148 99.80 Very High Very High Very High
Angina 99 99.52 Very High Very High Very High
Buprenorphine 63 99.52 Very High Very High Very High
methotrexate 13 99.40 Very High Very High Very High
alcohol 33 97.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 314 100.00 Very High Very High Very High
Coronary Artery Disease 83 100.00 Very High Very High Very High
Pain 29 100.00 Very High Very High Very High
Post Operative Pain 7 99.96 Very High Very High Very High
Cv General 3 Under Development 124 99.52 Very High Very High Very High
Acute Coronary Syndrome 38 99.48 Very High Very High Very High
Myocardial Infarction 30 99.48 Very High Very High Very High
Adhesions 14 99.44 Very High Very High Very High
Cv Unclassified Under Development 32 99.32 Very High Very High Very High
Cancer 22 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Within each treatment group, significant postoperative changes in C-reactive protein levels, leukocyte count, and body temperature were noted when compared with preoperative values.
Regulation (changes) of C-reactive protein in body
1) Confidence 0.46 Published 1998 Journal Plast. Reconstr. Surg. Section Abstract Doc Link 9583482 Disease Relevance 0.25 Pain Relevance 0.27
The postoperative serum C-reactive protein level was found to affect postoperative pain, and there was a larger extension lag and more subsidence of the implant in those with the mutilating type of the disease.
Regulation (affect) of C-reactive protein associated with perioperative pain and disease
2) Confidence 0.44 Published 2002 Journal J Hand Surg Br Section Abstract Doc Link 12027497 Disease Relevance 0.36 Pain Relevance 0.18
Imidazole.2-hydroxybenzoate was more effective than sulindac on Ritchie's articular index, left hand proximal interphalangeal joint circumference, erythrocyte sedimentation rate, and C-reactive protein.
Regulation (effective) of C-reactive protein in erythrocyte
3) Confidence 0.44 Published 1986 Journal Clin Ther Section Abstract Doc Link 3521858 Disease Relevance 0.25 Pain Relevance 0.17
This study examined the effect of chromium niacinate (Cr-N) or chromium picolinate (Cr-P) supplementation on lipid peroxidation (LP), TNF-alpha, IL-6, C-reactive protein (CRP), glycosylated hemoglobin (HbA(1)), cholesterol, and triglycerides (TG) in diabetic rats.
Spec (examined) Regulation (effect) of C-reactive protein associated with diabetes mellitus
4) Confidence 0.35 Published 2007 Journal Free Radic. Biol. Med. Section Abstract Doc Link 17854708 Disease Relevance 0.34 Pain Relevance 0.07
It has also been suggested that circulating C-reactive protein levels may not reflect all relevant inflammatory effectors, owing to post-transcriptional regulation of C-reactive protein [22].
Regulation (regulation) of C-reactive protein associated with inflammation
5) Confidence 0.34 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1160573 Disease Relevance 0.65 Pain Relevance 0.13
In particular, we examined changes in C-reactive protein, white blood cell count, albumin, and fibrinogen.
Spec (examined) Regulation (changes) of C-reactive protein in white blood cell
6) Confidence 0.34 Published 2005 Journal PLoS Medicine Section Abstract Doc Link PMC1160573 Disease Relevance 2.09 Pain Relevance 0.36
While the imputation may have diluted the effect of the prioritisation strategies including highly sensitive C reactive protein, the relative risks estimates for C reactive protein are likely to be inflated because of publication bias and inadequate adjustment for the routinely recorded factors known to relate to both highly sensitive C reactive protein and outcome (including smoking, diabetes, obesity, and lipid concentrations).17 Even when using the upper 95% confidence limit for the C reactive protein effect, a prioritisation strategy with a risk score using information from highly sensitive C reactive protein and estimated glomerular filtration rate had an incremental cost effectiveness ratio exceeding £40?
Regulation (effect) of reactive protein in upper associated with nicotine addiction, diabetes mellitus and obesity
7) Confidence 0.31 Published 2010 Journal BMJ : British Medical Journal Section Body Doc Link PMC2808469 Disease Relevance 0.29 Pain Relevance 0
However, limited information is available concerning the value of C-reactive protein levels in patients with acute myocardial infarction.
Regulation (value) of C-reactive protein associated with myocardial infarction
8) Confidence 0.27 Published 2003 Journal Am. J. Med. Section Abstract Doc Link 14693321 Disease Relevance 0.27 Pain Relevance 0.10
Effect of nifedipine on C-reactive protein levels in the coronary sinus and on coronary blood flow in response to acetylcholine in patients with stable angina pectoris having percutaneous coronary intervention.
Regulation (Effect) of C-reactive protein in coronary sinus associated with stable angina pectoris and angina
9) Confidence 0.27 Published 2005 Journal Am. J. Cardiol. Section Title Doc Link 15877999 Disease Relevance 0.28 Pain Relevance 0.27
The mean values of the serum C-reactive protein on postoperative days 1, 3, and 7 were significantly less in the LA group.
Regulation (values) of C-reactive protein
10) Confidence 0.27 Published 2001 Journal Surg Laparosc Endosc Percutan Tech Section Abstract Doc Link 11444750 Disease Relevance 1.28 Pain Relevance 0.34
PURPOSE: To investigate the prognostic value of elevated C-reactive protein levels in patients with stable angina who underwent coronary stenting.
Spec (investigate) Regulation (value) of C-reactive protein associated with angina
11) Confidence 0.27 Published 2003 Journal Am. J. Med. Section Abstract Doc Link 12829197 Disease Relevance 0.17 Pain Relevance 0.17
The number of swollen and tender joints, duration of morning stiffness, erythrocyte sedimentation rate, C-reactive protein, and hemoglobin levels showed significant improvement after pulse therapy.
Regulation (number) of C-reactive protein in joints
12) Confidence 0.24 Published 2008 Journal Clin. Rheumatol. Section Abstract Doc Link 18604580 Disease Relevance 1.45 Pain Relevance 0.26
MTX (5 mg) induced a significant effect on the Ritchie joint index, morning stiffness, pain, ESR and C-reactive protein.
Regulation (effect) of C-reactive protein in joint associated with pain and methotrexate
13) Confidence 0.24 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 8348281 Disease Relevance 0.20 Pain Relevance 0.51
In the BPN/VPA group there was no change in haemoglobin, leucocytes or C-reactive protein (CRP) during treatment.
Neg (no) Regulation (change) of C-reactive protein in leucocytes associated with buprenorphine
14) Confidence 0.24 Published 2006 Journal BMC Psychiatry Section Body Doc Link PMC1660570 Disease Relevance 0.56 Pain Relevance 1.07
There were no statistically significant differences between subgroups, neither in the median value of the C-reactive protein: 4.49 mg/l in infarction versus 4.5 mg/l in Angina (p = ns) nor in the percentage of patients with high levels of C-reactive protein (77% in infarction versus 71% in Angina).
Regulation (value) of C-reactive protein
15) Confidence 0.24 Published 2002 Journal An Med Interna Section Body Doc Link 12152386 Disease Relevance 0.12 Pain Relevance 0
Effect of antispastic agents (calcium antagonists and/or isosorbide dinitrate) on high-sensitivity C-reactive protein in patients with coronary vasospastic angina pectoris and no hemodynamically significant coronary artery disease.
Regulation (Effect) of C-reactive protein in coronary artery associated with angina, coronary artery disease and antagonist
16) Confidence 0.23 Published 2005 Journal Am. J. Cardiol. Section Title Doc Link 15619396 Disease Relevance 0.19 Pain Relevance 0.28
The aim of this study was to investigate the prognostic value of C-reactive protein elevation in a large population with unstable angina.
Spec (investigate) Regulation (value) of C-reactive protein associated with angina
17) Confidence 0.23 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9352968 Disease Relevance 0.75 Pain Relevance 0.64
Value of C-reactive protein in patients with stable angina pectoris, coronary narrowing (30% to 70%), and normal fractional flow reserve.
Regulation (Value) of C-reactive protein associated with stable angina pectoris and angina
18) Confidence 0.23 Published 2003 Journal Am. J. Cardiol. Section Title Doc Link 12972111 Disease Relevance 0.19 Pain Relevance 0.15
The value of high-sensitivity C-reactive protein and other inflammatory markers (leukocytes and fibrinogen) were analysed and were compared in those patients with unstable angina versus myocardial infarction without ST elevation.
Regulation (value) of C-reactive protein in leukocytes
19) Confidence 0.21 Published 2002 Journal An Med Interna Section Body Doc Link 12152386 Disease Relevance 0.18 Pain Relevance 0
This was not observed in those patients who received amlodipine monotherapy, in whom there was no systematic change in high-sensitivity C-reactive protein associated with ischaemia reduction [median 0.2 mg/L, P = 0.113 (Pearson's correlation coefficient ?
Neg (no) Regulation (change) of C-reactive protein associated with cv unclassified under development
20) Confidence 0.17 Published 2010 Journal European Heart Journal Section Body Doc Link PMC2966969 Disease Relevance 0.41 Pain Relevance 0

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