INT37392

Context Info Confidence 0.61 First Reported 1986 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 6 Disease Relevance 0.96 Pain Relevance 2.49

Anatomy Link Frequency parietal 3 vein 1 BAS (Homo sapiens)

Pain Link Frequency Relevance Heat midbrain 147 99.30 amygdala 9 98.18 Thalamus 39 97.64 insula 6 95.64 cocaine 198 85.60 Dismenorea 1 76.76 Anterior cingulate 6 70.00 headache 2 63.00 cva 2 56.96 antagonist 1 39.40

Disease Link Frequency Relevance Heat Mrsa Infection 4 97.88 Chills 2 92.40 Aspiration Pneumonia 2 87.96 Death 2 86.48 Infection 12 77.16 Dysmenorrhea 1 76.76 Urinary Tract Infection 2 73.88 Arrhythmias 2 Under Development 2 69.28 Head Trauma 7 64.08 Headache 2 63.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Biological profile of a bioactive aortic substance (BAS), released by vessel rings from indomethacin-treated rats.

Localization (released) of BAS

1) Confidence 0.61 Published 1986 Journal Prostaglandins Leukot Med Section Title Doc Link 3523541 Disease Relevance 0.08 Pain Relevance 0.08

Across subjects, bilateral occipital (BAs 17-19 and 37), temporal (BA 21), and cingulate (BAs 24, 30) cortex, ventral precuneus (BA 7), thalamus, parahippocampus, amygdala, putamen, caudate, cerebellum, and pons had positive CM (pcorr <0.001; Fig. 6); temporal (BAs 20, 22), parietal (BAs 2, 3, and 5), prefrontal (BA 9), cingulate (BA 32), and orbitofrontal (BAs 11 and 47) cortex, and posterior insula had negative CM (pcorr <0.001; Fig. 6).

Localization (parietal) of BAs in parietal associated with insula, midbrain, thalamus and amygdala

2) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2876035 Disease Relevance 0 Pain Relevance 0.83

Across subjects, bilateral occipital (BAs 17-19 and 37), temporal (BA 21), and cingulate (BAs 24, 30) cortex, ventral precuneus (BA 7), thalamus, parahippocampus, amygdala, putamen, caudate, cerebellum, and pons had positive CM (pcorr <0.001; Fig. 6); temporal (BAs 20, 22), parietal (BAs 2, 3, and 5), prefrontal (BA 9), cingulate (BA 32), and orbitofrontal (BAs 11 and 47) cortex, and posterior insula had negative CM (pcorr <0.001; Fig. 6).

Localization (occipital) of BAs in parietal associated with insula, midbrain, thalamus and amygdala

3) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2876035 Disease Relevance 0 Pain Relevance 0.67

Across subjects, bilateral occipital (BAs 17-19 and 37), temporal (BA 21), and cingulate (BAs 24, 30) cortex, ventral precuneus (BA 7), thalamus, parahippocampus, amygdala, putamen, caudate, cerebellum, and pons had positive CM (pcorr <0.001; Fig. 6); temporal (BAs 20, 22), parietal (BAs 2, 3, and 5), prefrontal (BA 9), cingulate (BA 32), and orbitofrontal (BAs 11 and 47) cortex, and posterior insula had negative CM (pcorr <0.001; Fig. 6).

Localization (parietal) of BAs in parietal associated with insula, midbrain, thalamus and amygdala

4) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2876035 Disease Relevance 0 Pain Relevance 0.83

Several blood cultures (from the CVC or from the peripheral vein), urine and bronchial secretions (BAS) were collected for cultures.

Localization (secretions) of BAS in vein

5) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2844393 Disease Relevance 0.62 Pain Relevance 0.09

KPC: Klebsiella pneumoniae carbapenemase; CVC: Central venousdevice; ICARE: Intensive Care Antimicrobial Resistance Epidemiology; ICU: Intensive care unit; TMP-SMX: Trimethoprim-sulfamethoxazole; CT: Computed Tomography; BAS: Bronchial secretions; CLSI: Clinical Laboratory Standards Institute; MBL: Metallo-beta-lactamases.

Localization (secretions) of BAS associated with mrsa infection

6) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2844393 Disease Relevance 0.26 Pain Relevance 0

General Comments

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