INT374

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Context Info
Confidence 0.70
First Reported 1978
Last Reported 2011
Negated 4
Speculated 2
Reported most in Abstract
Documents 212
Total Number 215
Disease Relevance 107.08
Pain Relevance 47.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ldha) mitochondrion (Ldha) oxidoreductase activity (Ldha)
cytoplasm (Ldha)
Anatomy Link Frequency
blood 13
hepatocytes 8
plasma 7
liver 6
lung 5
Ldha (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 187 100.00 Very High Very High Very High
cytokine 140 100.00 Very High Very High Very High
Glutamate 62 100.00 Very High Very High Very High
metalloproteinase 48 100.00 Very High Very High Very High
Dorsal horn 47 100.00 Very High Very High Very High
lidocaine 31 100.00 Very High Very High Very High
Catecholamine 16 100.00 Very High Very High Very High
ischemia 224 99.98 Very High Very High Very High
imagery 81 99.86 Very High Very High Very High
Paracetamol 215 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 183 100.00 Very High Very High Very High
Cancer 132 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 22 100.00 Very High Very High Very High
Hypoxia 266 99.98 Very High Very High Very High
Coronary Artery Disease 211 99.98 Very High Very High Very High
Toxicity 363 99.96 Very High Very High Very High
Hypoalbuminemia 2 99.96 Very High Very High Very High
Injury 557 99.90 Very High Very High Very High
Liver Disease 201 99.88 Very High Very High Very High
Pressure And Volume Under Development 64 99.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Some neurons in the parietal area of the cerebral cortex and endotheliocytes in blood vessels showed increases in NO synthesis and in the activity of energy metabolism enzymes (SDH, LDH).
Positive_regulation (increases) of LDH in cerebral cortex associated with cerebral cortex
1) Confidence 0.70 Published 2004 Journal Neurosci. Behav. Physiol. Section Abstract Doc Link 15526421 Disease Relevance 0.17 Pain Relevance 0.23
After the 60- and 120-min incubation with lidocaine, the amount of LDH activity was significantly increased compared with the choline group and was similar to that of the group incubated in distilled water.
Positive_regulation (increased) of LDH associated with lidocaine
2) Confidence 0.70 Published 2000 Journal Anesth. Analg. Section Abstract Doc Link 11004054 Disease Relevance 0.07 Pain Relevance 0.87
The induced LDH leakage was completed in 1 hr and the LDH activity was stable in storage at 10 degrees for 2 weeks.
Positive_regulation (induced) of LDH
3) Confidence 0.70 Published 1988 Journal Cell Biol. Toxicol. Section Abstract Doc Link 3228704 Disease Relevance 0 Pain Relevance 0.15
When transit ischemic treatment (for 15 min) was performed by ligation of both hepatic artery and portal vein, LDH activity increased significantly, which continued for over 5 h.
Positive_regulation (increased) of LDH in portal vein
4) Confidence 0.69 Published 1996 Journal Anal. Biochem. Section Abstract Doc Link 8660563 Disease Relevance 0.09 Pain Relevance 0.12
In all tested lung cells, propranolol caused concentration-dependent decreases of MTT reduction and LDH retention in the fraction of attached cells, which was associated with an increase of LDH activity in the medium and in the fraction of non-attached cells.
Positive_regulation (increase) of LDH in lung
5) Confidence 0.69 Published 2003 Journal Methods Find Exp Clin Pharmacol Section Abstract Doc Link 14571279 Disease Relevance 0.08 Pain Relevance 0.10
Ischemia-reperfusion (I/R) induced by 30-min of ischemia and 60-min of reperfusion significantly increased the levels of malondialdehyde (MDA) and lactate dehydrogenase (LDH) and resulted in serious intestinal edema (wet weight/dry weight).
Positive_regulation (increased) of lactate dehydrogenase associated with pressure and volume under development and ischemia
6) Confidence 0.69 Published 2001 Journal Life Sci. Section Abstract Doc Link 11212864 Disease Relevance 0.63 Pain Relevance 0.58
Ischemia-reperfusion (I/R) induced by 30-min of ischemia and 60-min of reperfusion significantly increased the levels of malondialdehyde (MDA) and lactate dehydrogenase (LDH) and resulted in serious intestinal edema (wet weight/dry weight).
Positive_regulation (increased) of LDH associated with pressure and volume under development and ischemia
7) Confidence 0.69 Published 2001 Journal Life Sci. Section Abstract Doc Link 11212864 Disease Relevance 0.63 Pain Relevance 0.58
A massive secretion of CA obtained after switchover from hypertonic to normotonic solution was not associated with an increase in lactate dehydrogenase content in the perfusate, nor was there any reduction in the lactate dehydrogenase content of the adrenal medulla.
Positive_regulation (increase) of lactate dehydrogenase in adrenal medulla associated with medulla and catecholamine
8) Confidence 0.68 Published 1986 Journal J. Neurosci. Section Abstract Doc Link 2427669 Disease Relevance 0 Pain Relevance 0.56
G. biloba extract alone increased LDH leakage in hepatocytes at concentrations > or =75 mug/ml and > or =750 mug/ml after a 72 h and 24 h treatment period, respectively.
Positive_regulation (increased) of LDH in hepatocytes
9) Confidence 0.68 Published 2006 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17045319 Disease Relevance 0.26 Pain Relevance 0.34
An increase in LDH was observed in both sexes given 5400 mg/kg/day and half of these animals also showed increases in GOT and Urea N. 7.
Positive_regulation (increase) of LDH
10) Confidence 0.67 Published 1992 Journal J Toxicol Sci Section Abstract Doc Link 1321257 Disease Relevance 0.59 Pain Relevance 0.09
Serum LDH, BUN and creatinin levels were significantly increased in the morphine group compared to the tramadol group.
Positive_regulation (increased) of LDH associated with tramadol and morphine
11) Confidence 0.66 Published 2005 Journal J. Biosci. Section Abstract Doc Link 15886461 Disease Relevance 0.23 Pain Relevance 1.42
APAP toxicity in renal slices from both 3- and 12-month-old rats was characterized by concentration-dependent increases in LDH leakage.
Positive_regulation (increases) of LDH associated with toxicity and paracetamol
12) Confidence 0.66 Published 1990 Journal Toxicol. Lett. Section Abstract Doc Link 2356566 Disease Relevance 0.78 Pain Relevance 1.42
The lactate dehydrogenase level was increased in case 1 and the dihydroepiandostrone level was increased in both cases.
Positive_regulation (increased) of lactate dehydrogenase
13) Confidence 0.66 Published 2002 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11961390 Disease Relevance 0.26 Pain Relevance 0.10
After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 mug/kg).
Positive_regulation (elevated) of LDH
14) Confidence 0.64 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19280152 Disease Relevance 0.66 Pain Relevance 0.15
After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 mug/kg).
Positive_regulation (elevated) of lactate dehydrogenase
15) Confidence 0.64 Published 2009 Journal Arch. Pharm. Res. Section Abstract Doc Link 19280152 Disease Relevance 0.66 Pain Relevance 0.15
The n-3 PUFA caused increases in the activities of HK, G6PD, LDH, and MDH in comparison with control.
Positive_regulation (increases) of LDH
16) Confidence 0.64 Published 2004 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Abstract Doc Link 15207530 Disease Relevance 0.09 Pain Relevance 0.09
Similarly, serum TNF-alpha and LDH were elevated in the burn group as compared to control group.
Positive_regulation (elevated) of LDH associated with burns
17) Confidence 0.64 Published 2006 Journal Burns Section Abstract Doc Link 16926069 Disease Relevance 1.34 Pain Relevance 0.06
When tested 0.5, 1, 2, 4, 8 and 24 hrs after cocaine administration, sublethal dose of cocaine (80 mg/kg ip) injection resulted in significant increase in the plasma lactate dehydrogenase (LDH) levels.
Positive_regulation (increase) of LDH in plasma associated with cocaine
18) Confidence 0.63 Published 1991 Journal Life Sci. Section Abstract Doc Link 1745104 Disease Relevance 0.30 Pain Relevance 1.14
This was probably due to inhibition of hepatocyte activity by halothane because increases in GOT, LDH and lactate in the perfusate and a decrease in the O2 consumption by the rat liver were observed.
Positive_regulation (increases) of LDH in liver associated with halothane
19) Confidence 0.62 Published 1991 Journal Masui Section Abstract Doc Link 2051575 Disease Relevance 0.09 Pain Relevance 0.75
Serum LDH levels were significantly increased as the patients approached death.
Positive_regulation (increased) of Serum LDH associated with death
20) Confidence 0.58 Published 2007 Journal Eur. J. Cancer Section Abstract Doc Link 17349786 Disease Relevance 0.69 Pain Relevance 0.09

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