INT37405

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Context Info
Confidence 0.49
First Reported 1986
Last Reported 2007
Negated 1
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.32
Pain Relevance 2.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cst7)
Anatomy Link Frequency
muscle 2
skin 1
wrist 1
Cst7 (Mus musculus)
Pain Link Frequency Relevance Heat
Action potential 39 100.00 Very High Very High Very High
carpal tunnel syndrome 22 98.86 Very High Very High Very High
Demyelination 1 85.52 High High
nerve block 1 75.00 Quite High
anesthesia 1 71.52 Quite High
Inflammatory response 2 54.16 Quite High
Sciatic nerve 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 57 99.76 Very High Very High Very High
Neuropathy 28 99.28 Very High Very High Very High
Carpal Tunnel Syndrome 22 98.86 Very High Very High Very High
Neurologic Manifestations 1 94.40 High High
Demyelinating Disease 1 85.52 High High
Arrhythmias 2 Under Development 3 79.48 Quite High
Lipidosis 2 75.00 Quite High
Frailty 1 71.48 Quite High
Death 1 68.16 Quite High
Neuropathic Pain 1 60.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ratio of pCMAP to dCMAP amplitudes was reduced in the Twitcher, 0.39 +/- 0.13 (10), compared with controls 0.72 +/- 0.17 (21) and the ratio of pCMAP to dCMAP phases was increased (2.8 +/- 0.8 (10) vs 1.0 +/- 0.2 (21), P less than 0.01 for all).
Positive_regulation (increased) of dCMAP
1) Confidence 0.49 Published 1986 Journal J. Neurol. Sci. Section Abstract Doc Link 3525759 Disease Relevance 0.36 Pain Relevance 0.11
Upon muscle lengthening with relaxation, both groups showed a reduction in CMAP amplitude and an increase in CMAP duration.
Positive_regulation (increase) of CMAP in muscle
2) Confidence 0.40 Published 2005 Journal J Electromyogr Kinesiol Section Abstract Doc Link 15763674 Disease Relevance 0.54 Pain Relevance 0.62
Muscle shortening with contraction afforded decreased CMAP duration and increased CMAP amplitude in both groups.
Positive_regulation (increased) of CMAP in Muscle
3) Confidence 0.40 Published 2005 Journal J Electromyogr Kinesiol Section Abstract Doc Link 15763674 Disease Relevance 0.54 Pain Relevance 0.62
In 16% of CTS hands there was an abnormal amplitude reduction without increased duration of CMAP or SNAP from wrist stimulation indicating partial conduction block.
Neg (without) Positive_regulation (increased) of CMAP in wrist associated with action potential and carpal tunnel syndrome
4) Confidence 0.21 Published 1997 Journal Electroencephalogr Clin Neurophysiol Section Abstract Doc Link 9284240 Disease Relevance 0.50 Pain Relevance 0.80
Hot, cold, pinprick, light touch sensations, SNAP and CMAP were significantly inhibited, and skin temperature was significantly increased after administration of both agents.
Positive_regulation (increased) of CMAP in skin associated with action potential
5) Confidence 0.21 Published 1998 Journal Br J Anaesth Section Abstract Doc Link 9924223 Disease Relevance 0 Pain Relevance 0.44
Furthermore, a significant increase in CMAP amplitude was evidenced beginning 4 weeks after surgery.
Positive_regulation (increase) of CMAP
6) Confidence 0.21 Published 2003 Journal Clin Neurophysiol Section Body Doc Link 12804677 Disease Relevance 0.07 Pain Relevance 0
Key messages

• CMAP durations were increased in a sepsis model in rats in the first 24 hours. • CMAP amplitudes were significantly decreased in a sepsis model in rats in the first 24 hours. • Latency times were significantly prolonged in a sepsis model in rats in the first 24 hours. • Electrophysiological changes seen in sepsis might appear before clinical signs of CIP.


Positive_regulation (increased) of CMAP associated with neuropathy, action potential and sepsis
7) Confidence 0.09 Published 2007 Journal Crit Care Section Body Doc Link PMC2151871 Disease Relevance 1.29 Pain Relevance 0.40

General Comments

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