INT37416

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 2.02
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Pcsk1) extracellular space (Pcsk1) embryo development (Pcsk1)
Anatomy Link Frequency
marginal zone 1
Pcsk1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dynorphin 10 86.76 High High
Inflammation 6 81.52 Quite High
Neurotransmitter 1 78.48 Quite High
Neuropeptide 7 75.00 Quite High
headache 3 75.00 Quite High
Pain 2 75.00 Quite High
Spinal cord 1 75.00 Quite High
antinociception 2 56.28 Quite High
Opioid 1 54.76 Quite High
fibrosis 2 47.20 Quite Low
Disease Link Frequency Relevance Heat
Lung Injury 18 92.48 High High
Disease 13 91.32 High High
Adult Respiratory Distress Syndrome 40 89.20 High High
Bacterial Respiratory Disease 2 85.60 High High
INFLAMMATION 10 81.52 Quite High
Headache 4 75.00 Quite High
Infection 1 59.44 Quite High
Death 4 51.76 Quite High
Respiratory Failure 4 50.92 Quite High
Pulmonary Fibrosis 2 47.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PC1/3 and PC2 substrate proenkephalin was also induced following lipopolysaccharide treatment in the marginal zone, where PC1/3 expression was also found.
Positive_regulation (induced) of PC1 in marginal zone
1) Confidence 0.67 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16337011 Disease Relevance 0.22 Pain Relevance 0.04
This study demonstrates that during gestation and HSP, lumbar PC2 protein content, but not that of PC1, is augmented.
Positive_regulation (augmented) of PC1
2) Confidence 0.45 Published 1999 Journal Neuroendocrinology Section Abstract Doc Link 10529622 Disease Relevance 0 Pain Relevance 0.52
RHINOS is widely available because it is implemented by Prolog-KABA which is operative on personal computers such as NEC PC9801 and IBM-PC.
Positive_regulation (operative) of NEC PC9801
3) Confidence 0.37 Published 1986 Journal Comput Methods Programs Biomed Section Abstract Doc Link 3527551 Disease Relevance 0.84 Pain Relevance 0.27
We first asked whether the N-terminal domain of proSAAS (proSAAS-(1-180)) could stabilize PC1 activity, similar to the effect of the N-terminal domain of 7B2 on PC2.
Positive_regulation (stabilize) of PC1
4) Confidence 0.22 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11719503 Disease Relevance 0 Pain Relevance 0
Surprisingly, cotransfection of proSAAS-(1-180) cDNA, encoding a protein that lacks the inhibitory C-terminal domain peptide, also reduced the activity of PC1 detected in the medium, but the mass of PC1 secreted into the medium was increased, suggesting a proSAAS-mediated inactivation reaction.
Positive_regulation (increased) of PC1
5) Confidence 0.16 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11719503 Disease Relevance 0 Pain Relevance 0
1 challenge, whereas PC-1 was upregulated after 12 hours (Figure 1c).
Positive_regulation (upregulated) of PC-1
6) Confidence 0.16 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
In these conditions, PC-1 was induced approximately 2-fold after 12 hours and reached a maximal induction of approximately 3.5-fold after 24 hours of stimulation with TGF-?
Positive_regulation (induced) of PC-1
7) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
Surprisingly, cotransfection of proSAAS-(1-180) cDNA, encoding a protein that lacks the inhibitory C-terminal domain peptide, also reduced the activity of PC1 detected in the medium, but the mass of PC1 secreted into the medium was increased, suggesting a proSAAS-mediated inactivation reaction.
Positive_regulation (increased) of PC1
8) Confidence 0.13 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 11719503 Disease Relevance 0 Pain Relevance 0
Nevertheless, studies have shown that an increase in mRNA PC I is consistent with an increase in PC I protein levels [22-24].
Positive_regulation (increase) of PC I
9) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.43 Pain Relevance 0.04
Nevertheless, studies have shown that an increase in mRNA PC I is consistent with an increase in PC I protein levels [22-24].
Positive_regulation (increase) of PC I
10) Confidence 0.01 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.53 Pain Relevance 0.04

General Comments

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