INT37430

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Context Info
Confidence 0.63
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 61
Total Number 64
Disease Relevance 54.63
Pain Relevance 13.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (Gpi1) carbohydrate metabolic process (Gpi1) cytoplasm (Gpi1)
cytosol (Gpi1) extracellular space (Gpi1) extracellular region (Gpi1)
Anatomy Link Frequency
NK cells 6
joints 5
T cells 5
granulocytes 2
reticulum 2
Gpi1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 2984 100.00 Very High Very High Very High
rheumatoid arthritis 1711 99.80 Very High Very High Very High
imagery 162 99.04 Very High Very High Very High
Inflammatory mediators 3 98.20 Very High Very High Very High
cytokine 72 97.76 Very High Very High Very High
Inflammation 380 97.72 Very High Very High Very High
methotrexate 20 96.08 Very High Very High Very High
cINOD 12 91.48 High High
positron emission tomography 16 89.88 High High
Angina 3 85.28 High High
Disease Link Frequency Relevance Heat
Arthritis 3364 100.00 Very High Very High Very High
Paroxysmal Nocturnal Hemoglobinuria 873 99.84 Very High Very High Very High
Rheumatoid Arthritis 1711 99.80 Very High Very High Very High
Disease 599 99.80 Very High Very High Very High
Immunization 379 99.80 Very High Very High Very High
Apoptosis 40 99.70 Very High Very High Very High
Atherosclerosis 18 99.48 Very High Very High Very High
Chronic Disease 46 99.42 Very High Very High Very High
Rheumatic Diseases 50 99.20 Very High Very High Very High
Targeted Disruption 371 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in contrast to the K/B×N model, in which Th cells are only necessary to provide help to B cells that produce the arthritogenic antibodies against G6PI.
Gene_expression (produce) of G6PI in B cells
1) Confidence 0.63 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.61 Pain Relevance 0.53
G6PI deposits, together with IgG and C3, are detectable in the joints of arthritic mice in the K/B×N serum transfer model [98].
Gene_expression (detectable) of G6PI in joints associated with arthritis
2) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.79 Pain Relevance 0.24
Interestingly, although GPI is ubiquitously expressed in the body, the immune response against GPI appears to initiate in the draining lymph nodes of peripheral joints in K/B×N mice [94].
Gene_expression (expressed) of GPI in joints
3) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.97 Pain Relevance 0.39
It is currently unclear why systemic autoreactivity against the ubiquitously expressed glycolytic enzyme G6PI specifically induces arthritis, with no other symptoms of organ-specific or systemic autoimmune disease.
Gene_expression (expressed) of G6PI associated with autoimmune disease and arthritis
4) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.15 Pain Relevance 0.44
However, systemically expressed antigens such as G6PI are not only presented in the joint, and not every cationic antigen induces arthritis upon immunization.
Gene_expression (presented) of G6PI in joint associated with immunization and arthritis
5) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.81 Pain Relevance 0.27
Thus, in G6PI-induced arthritis in normal mice, CD4+ cells are not only important in the induction but also throughout the effector phase of the disease.
Gene_expression (important) of G6PI associated with disease and arthritis
6) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.55 Pain Relevance 0.50
Autoreactivity against G6PI in the pathogenesis of RA?
Gene_expression (Autoreactivity) of G6PI associated with rheumatoid arthritis
7) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.11 Pain Relevance 0.46
However, systemically expressed antigens such as G6PI are not only presented in the joint, and not every cationic antigen induces arthritis upon immunization.
Gene_expression (expressed) of G6PI in joint associated with immunization and arthritis
8) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 0.85 Pain Relevance 0.29
An interesting further twist in the story was added by a recent report. van Gaalen and coworkers [85] found that whereas only one of 55 RA patients who did not have systemic manifestations of the disease produced antibodies against G6PI, seven of 22 patients with systemic manifestations (nodules or vasculitis) and 12 of 13 patients with Felty's syndrome had detectable ?
Gene_expression (antibodies) of G6PI in nodules associated with syndrome, rheumatoid arthritis, increased venous pressure under development and disease
9) Confidence 0.55 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.31 Pain Relevance 0.33
In the K/B×N T-cell receptor transgenic mouse model arthritis is caused by a systemic autoimmune response to the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI).
Gene_expression (expressed) of glucose-6-phosphate in T-cell associated with targeted disruption and arthritis
10) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064898 Disease Relevance 1.15 Pain Relevance 0.35
In the K/B×N T-cell receptor transgenic mouse model arthritis is caused by a systemic autoimmune response to the ubiquitously expressed glycolytic enzyme glucose-6-phosphate isomerase (G6PI).
Gene_expression (expressed) of G6PI in T-cell associated with targeted disruption and arthritis
11) Confidence 0.49 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064898 Disease Relevance 1.16 Pain Relevance 0.35
Arthritis can be induced in recipient mice by transfer of polyclonal IgG1 or combinations of at least two different monoclonal IgG1 antibodies against G6PI [69].
Gene_expression (transfer) of G6PI associated with arthritis
12) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.02 Pain Relevance 0.37
-G6PI antibodies in the synovial fluid of RA patients.
Gene_expression (antibodies) of G6PI in synovial fluid associated with rheumatoid arthritis
13) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.32 Pain Relevance 0.38
One initial report [79] indicated that IgG antibodies against G6PI were detectable at low dilution (1:50) in the serum of 64% of RA patients but not in control individuals.
Gene_expression (antibodies) of G6PI associated with rheumatoid arthritis
14) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.13 Pain Relevance 0.44
Why G6PI?
Gene_expression (Why) of G6PI
15) Confidence 0.48 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064898 Disease Relevance 1.12 Pain Relevance 0.23
The autoreactive transgenic T cells recognize G6PI and provide help for the production of arthritogenic IgG antibodies against G6PI.
Gene_expression (production) of G6PI in T cells associated with targeted disruption
16) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064898 Disease Relevance 1.16 Pain Relevance 0.35
The target antigen for the initiating T cells and the arthritogenic immunoglobulin G has now, surprisingly, been identified as glucose-6-phosphate iso-merase (GPI), which is a glycolytic enzyme that is expressed in all tissues [15].
Gene_expression (expressed) of GPI in T cells
17) Confidence 0.38 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129986 Disease Relevance 1.24 Pain Relevance 0.37
Starting for STN and GPi, respectively, 8 and 12 mm above the MRI-based target, the microelectrodes were advanced in steps of 500 ?
Gene_expression (respectively) of GPi associated with imagery
18) Confidence 0.36 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.16
Starting for STN and GPi, respectively, 8 and 12 mm above the MRI-based target, the microelectrodes were advanced in steps of 500 ?
Gene_expression (for) of GPi associated with imagery
19) Confidence 0.36 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0 Pain Relevance 0.16
The bottom of the GPi is reached at 0 mm

Macro-test stimulation

Gene_expression (bottom) of GPi
20) Confidence 0.36 Published 2010 Journal Acta Neurochir (Wien) Section Body Doc Link PMC2991152 Disease Relevance 0.21 Pain Relevance 0.05

General Comments

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