INT37432

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Context Info
Confidence 0.11
First Reported 1986
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.60
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
eukaryotic cells 1
Shbdp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Somatosensory cortex 42 100.00 Very High Very High Very High
Glutamate 12 99.68 Very High Very High Very High
Enkephalin 14 84.88 Quite High
Multiple sclerosis 11 83.08 Quite High
Inflammation 25 82.96 Quite High
Intracerebroventricular 4 79.60 Quite High
allodynia 4 74.48 Quite High
addiction 5 68.60 Quite High
Central nervous system 16 68.32 Quite High
antagonist 27 53.76 Quite High
Disease Link Frequency Relevance Heat
Multiple Sclerosis 52 92.16 High High
Disease 22 86.36 High High
INFLAMMATION 25 82.96 Quite High
Recurrence 1 81.80 Quite High
Infection 20 77.72 Quite High
Nociception 1 76.16 Quite High
Neuropathic Pain 6 74.48 Quite High
Cough 2 70.76 Quite High
Bordatella Infection 7 66.92 Quite High
Adhesions 1 57.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
S2 binding induces the actin binding of S1 and severing and capping follow.
S2 Binding (binding) of
1) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2905391 Disease Relevance 0 Pain Relevance 0
In S2 (Figure 7G–I), an ascending L4?
S2 Binding (ascending) of associated with somatosensory cortex
2) Confidence 0.09 Published 2011 Journal PLoS Biology Section Body Doc Link PMC3014926 Disease Relevance 0 Pain Relevance 0.09
The B subunit contains S2–S5 and binds to the surface of many eukaryotic cells.
S2 Binding (binds) of in eukaryotic cells
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012729 Disease Relevance 1.45 Pain Relevance 0.25
Menthol readily interacted with the Y745 binding site, disrupting the potentially stabilizing interactions between this S2 residue and the D802 motif located on S3 as already suggested by Pedretti et al. [38].
S2 Binding (interactions) of
4) Confidence 0.06 Published 2009 Journal Mol Pain Section Body Doc Link PMC2778643 Disease Relevance 0.15 Pain Relevance 0.14
In contrast, Tyr-Phe-NHOH, designed to interact with S2,S1 subsites through its positively charged Tyr as the P2 component, is a highly potent (Ki = 9 nM) and selective DAP inhibitor.
S2 Binding (interact) of
5) Confidence 0.05 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.37
The compounds synthesized to bind the S1', S2' subsites, such as HN(OH)--CO--CH2--CH(CH2 phi)-CONH--CH(CH2 phi)--COOH, behave as highly potent and mixed inhibitors of both DAP (Ki = 2.5 nM) and enkephalinase (Ki = 0.3 nM).
S2 Binding (bind) of
6) Confidence 0.04 Published 1986 Journal Mol. Pharmacol. Section Abstract Doc Link 3531805 Disease Relevance 0 Pain Relevance 0.37
Rhodesain lacks the critical glutamate residue at the S2 site for arginine binding, and was reported to be inactive against substrates with arginine at P2.[29] Therefore, selectivity for cruzain over rhodesain was anticipated.
S2 Binding (binding) of associated with glutamate
7) Confidence 0.01 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2939063 Disease Relevance 0 Pain Relevance 0.05

General Comments

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