INT37490

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Context Info
Confidence 0.30
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Title
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1b1) endoplasmic reticulum (Cyp1b1)
Cyp1b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 7 99.92 Very High Very High Very High
palliative 1 88.08 High High
Enkephalin 1 66.08 Quite High
addiction 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 67 99.84 Very High Very High Very High
Hepatotoxicity 3 99.44 Very High Very High Very High
Hyperplasia 7 98.82 Very High Very High Very High
Recurrence 1 85.12 High High
Endometriosis (extended) 1 78.88 Quite High
Apoptosis 4 71.04 Quite High
Malignant Neoplastic Disease 6 68.20 Quite High
Cancer 60 67.04 Quite High
Body Weight 1 64.32 Quite High
Hereditary Nonpolyposis Colorectal Neoplasms 9 61.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Saini et al. reported that CYP1B1 depletion in endometrial cancer cells leads to decreased cellular proliferation and induced G0-G1 cell cycle arrest, thus suggesting that CYP1B1 inhibition in endometrial cancer cells could be a useful therapeutic approach [54].
Negative_regulation (inhibition) of CYP1B1 associated with endometrial cancer and hyperplasia
1) Confidence 0.30 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2852605 Disease Relevance 1.24 Pain Relevance 0.09
The substrate analogs guanidinoethylmercaptosuccinic acid, guanidinopropylsuccinic acid, and aminopropylmercaptosuccinic acid competitively inhibited the islet CP B with inhibition constant (Ki) values of 23, 21, and 230 nM, respectively.
Negative_regulation (inhibited) of CP B
2) Confidence 0.03 Published 1987 Journal Endocrinology Section Abstract Doc Link 3542502 Disease Relevance 0 Pain Relevance 0.07
Cytochrome P4502E1 inhibition by propylene glycol prevents acetaminophen (paracetamol) hepatotoxicity in mice without cytochrome P4501A2 inhibition.
Negative_regulation (inhibition) of P4501A2 associated with paracetamol and hepatotoxicity
3) Confidence 0.02 Published 1995 Journal Pharmacol. Toxicol. Section Title Doc Link 7479582 Disease Relevance 0.33 Pain Relevance 0.53

General Comments

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