INT375

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 9
Speculated 3
Reported most in Abstract
Documents 293
Total Number 296
Disease Relevance 152.46
Pain Relevance 47.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (REN) extracellular space (REN) extracellular region (REN)
intracellular (REN) response to stress (REN)
Anatomy Link Frequency
plasma 130
blood 24
heart 8
sympathetic 8
sympathetic nervous system 5
REN (Homo sapiens)
Pain Link Frequency Relevance Heat
Catecholamine 72 100.00 Very High Very High Very High
narcan 53 100.00 Very High Very High Very High
Pain 44 100.00 Very High Very High Very High
noradrenaline 36 100.00 Very High Very High Very High
Serotonin 13 100.00 Very High Very High Very High
Bile 13 100.00 Very High Very High Very High
Paracetamol 6 100.00 Very High Very High Very High
Clonidine 133 99.98 Very High Very High Very High
cva 120 99.84 Very High Very High Very High
Dopamine 38 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 786 100.00 Very High Very High Very High
Stress 215 100.00 Very High Very High Very High
Proteinuria 131 100.00 Very High Very High Very High
Renal Artery Obstruction 67 99.98 Very High Very High Very High
Heart Rate Under Development 409 99.96 Very High Very High Very High
Bartter Syndrome 42 99.96 Very High Very High Very High
Weight Loss 25 99.96 Very High Very High Very High
Acute Renal Failure 19 99.96 Very High Very High Very High
Bradycardia 1 99.96 Very High Very High Very High
Myocardial Infarction 676 99.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The contribution of neurogenic mechanisms in maintaining hypertension was investigated in 13 patients with unilateral renal artery stenosis (twelve with normal, one with grossly elevated plasma renin levels) by determining the haemodynamic and hormonal responses to the centrally acting sympatholytic agent, clonidine.
Positive_regulation (elevated) of plasma renin in renal artery associated with renal artery obstruction, hypertension and clonidine
1) Confidence 0.70 Published 1991 Journal Clin. Auton. Res. Section Abstract Doc Link 1822252 Disease Relevance 0.60 Pain Relevance 0.29
In the patient with grossly elevated renin levels, blood pressure fell minimally (6%) after clonidine, but unlike others fell profoundly (37%) after captopril.
Positive_regulation (elevated) of renin in blood associated with clonidine
2) Confidence 0.70 Published 1991 Journal Clin. Auton. Res. Section Abstract Doc Link 1822252 Disease Relevance 0.75 Pain Relevance 0.55
Clonidine exerted balanced effects on cardiac output and systemic vascular resistance while blood volume and plasma renin activity were slightly increased.
Positive_regulation (increased) of renin in plasma associated with clonidine
3) Confidence 0.70 Published 1987 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2455184 Disease Relevance 0.51 Pain Relevance 0.34
The blood pressure was markedly high when he visited our hospital and peripheral plasma renin activity was also elevated.
Positive_regulation (elevated) of renin in plasma
4) Confidence 0.70 Published 1985 Journal Hinyokika Kiyo Section Abstract Doc Link 3832924 Disease Relevance 0.62 Pain Relevance 0.10
Plasma renin activity was measured on the blood drawn from the renal vein of both sides and the ratio was about 2.4, and renin activity of the segmental renal vein from the left lower portion was elevated.
Positive_regulation (elevated) of renin in renal vein
5) Confidence 0.70 Published 1985 Journal Hinyokika Kiyo Section Abstract Doc Link 3832924 Disease Relevance 0.72 Pain Relevance 0.08
Lack of effect of naloxone in a moderate dosage on the exercise-induced increase in blood pressure, heart rate, plasma catecholamines, plasma renin activity and plasma aldosterone in healthy males.
Positive_regulation (increase) of renin in blood associated with pressure and volume under development, catecholamine and narcan
6) Confidence 0.70 Published 1985 Journal Clin. Sci. Section Title Doc Link 3881209 Disease Relevance 0.19 Pain Relevance 0.58
Compared with the control value (15.1 +/- 1.8 ng.ml-1.hr-1), plasma renin activity was activated 30 and 60 minutes after induction of hypotension (55.5 +/- 6.0 ng.ml-1.hr-1, P less than 0.001, 50.3 +/- 7.1 ng.ml-1.hr-1, P less than 0.01, respectively).
Positive_regulation (activated) of plasma renin in plasma associated with pressure volume 2 under development
7) Confidence 0.69 Published 1990 Journal Masui Section Abstract Doc Link 2232139 Disease Relevance 0.50 Pain Relevance 0.17
Renovascular hypertension (via decreased renal afferent arteriolar perfusion) and pheochromocytoma (via sympathetic nerve activation) both increase plasma renin and activate the angiotensin-aldosterone axis.
Positive_regulation (increase) of renin in plasma associated with hypertension and pheochromocytoma
8) Confidence 0.69 Published 2010 Journal J Gen Intern Med Section Body Doc Link PMC2811596 Disease Relevance 0.34 Pain Relevance 0.03
Increased prostaglandin production follows renin activation; simultaneously, the arterial vessels show diminished angiotensin sensitivity.
Positive_regulation (activation) of renin in vessels
9) Confidence 0.69 Published 1995 Journal Anaesthesist Section Abstract Doc Link 7653790 Disease Relevance 0.73 Pain Relevance 0
In additional experiments in which the plasma renin level was measured, the potentiation of responses to sympathetic stimulation and a high dose of norepinephrine (2 mug) occurred at the time that the renin level was increased by hemorrhage.
Positive_regulation (increased) of renin in sympathetic associated with cva
10) Confidence 0.69 Published 1975 Journal Am. J. Physiol. Section Abstract Doc Link 1115240 Disease Relevance 0.32 Pain Relevance 0.23
This produced a prompt and reversible increase in plasma renin activity. 2.
Positive_regulation (increase) of renin in plasma
11) Confidence 0.69 Published 1976 Journal Clin Sci Mol Med Suppl Section Abstract Doc Link 1071584 Disease Relevance 0 Pain Relevance 0.25
Her blood pressure was high and plasma renin activity and aldosterone levels were elevated.
Positive_regulation (elevated) of renin in plasma
12) Confidence 0.69 Published 1992 Journal Intern. Med. Section Abstract Doc Link 1351768 Disease Relevance 0.74 Pain Relevance 0.29
At increasing rates of renal nerve stimulation plasma renin activity was increased by 40, 70 and 180%.
Positive_regulation (increased) of renin in plasma
13) Confidence 0.69 Published 1984 Journal Comp Biochem Physiol A Comp Physiol Section Abstract Doc Link 6149845 Disease Relevance 0 Pain Relevance 0
Those patients with "low renin" hypertension (n = 7) were noted to show an increase in plasma renin activity; the patients with "normal renin" hypertension (n = 4) tended to show a decrease.
Positive_regulation (increase) of renin in plasma associated with hypertension
14) Confidence 0.69 Published 1983 Journal Chest Section Abstract Doc Link 6822131 Disease Relevance 0.82 Pain Relevance 0.35
Twenty-four hours after stenosis, when all dogs were fully conscious, significant elevations in mean arterial pressure and plasma renin activity were seen only in the dogs anaesthetized for stenosis production.
Positive_regulation (elevations) of renin in plasma associated with pathologic constriction
15) Confidence 0.69 Published 1980 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 7449193 Disease Relevance 0.71 Pain Relevance 0
The temporal relationships suggest that the increased sympathetic activity increases mean arterial blood pressure and heart rate, with mean arterial blood pressure also increased by increased plasma AVP concentration, whereas the delayed, increased plasma renin activity is likely a response to the ensuing hypotension, or earlier inhibition by AVP, or both.


Positive_regulation (increased) of renin in plasma
16) Confidence 0.68 Published 1994 Journal Anesthesiology Section Body Doc Link 8017643 Disease Relevance 0 Pain Relevance 0
The rapid increase to 1.66 MAC increased mean arterial blood pressure, heart rate, and plasma epinephrine and norepinephrine concentrations, and plasma renin activity with both desflurane and isoflurane, the former usually producing a response of greater magnitude than the latter.
Positive_regulation (increased) of renin in plasma
17) Confidence 0.68 Published 1994 Journal Anesthesiology Section Body Doc Link 8017643 Disease Relevance 0 Pain Relevance 0
A four-fold increase in plasma concentrations of renin and aldosterone was noted after pneumoperitoneum and reverse Trendelenburg positioning (P > 0.05).
Positive_regulation (increase) of renin in plasma associated with pneumoperitoneum
18) Confidence 0.68 Published 1996 Journal Br J Anaesth Section Abstract Doc Link 8688262 Disease Relevance 0.49 Pain Relevance 0.08
Renin and aldosterone secretion increase during sleep and are synchronized to the nonREM-REM cycle [36,37].
Positive_regulation (increase) of Renin
19) Confidence 0.68 Published 2003 Journal BMC Psychiatry Section Body Doc Link PMC280657 Disease Relevance 0.32 Pain Relevance 0.33
Rats that were made hyperuricemic rapidly developed hypertension through activation of the renin-angiontensin system, induction of endothelial dysfunction, and vascular smooth muscle proliferation.
Positive_regulation (activation) of renin in smooth muscle associated with hyperuricemia and hypertension
20) Confidence 0.67 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 1.58 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox