INT37532

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Context Info
Confidence 0.40
First Reported 1987
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.23
Pain Relevance 3.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bst1) molecular_function (Bst1) cellular_component (Bst1)
biological_process (Bst1)
Anatomy Link Frequency
neuronal 1
neurons 1
lateral 1
brain 1
neural 1
Bst1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 47 100.00 Very High Very High Very High
Pain 10 99.98 Very High Very High Very High
Dopamine 85 99.84 Very High Very High Very High
Enkephalin 7 98.20 Very High Very High Very High
Morphine 14 96.00 Very High Very High Very High
withdrawal 10 95.64 Very High Very High Very High
Lasting pain 2 94.04 High High
noradrenaline 2 89.52 High High
monoamine 1 86.84 High High
Sciatic nerve 1 79.52 Quite High
Disease Link Frequency Relevance Heat
Pain 12 99.98 Very High Very High Very High
Stress 23 99.82 Very High Very High Very High
Schizophrenia 220 97.80 Very High Very High Very High
Nociception 1 95.84 Very High Very High Very High
Injury 2 78.44 Quite High
Neuropathic Pain 1 76.88 Quite High
Aids-related Complex 7 71.56 Quite High
Autism 8 71.36 Quite High
Congenital Anomalies 44 50.00 Quite Low
Drug Dependence 1 38.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that activation of the BST mediated through the neural pathway from the Ce contributes to the negative affective component of morphine withdrawal.
Positive_regulation (activation) of BST in neural associated with withdrawal, amygdala and morphine
1) Confidence 0.40 Published 2005 Journal Neuroscience Section Abstract Doc Link 15939543 Disease Relevance 0 Pain Relevance 1.21
Altogether, this study demonstrates that pain induces nuclei-and condition-specific neuronal activation in the BST revealing an intriguing supraspinal neurobiological substrate that may contribute to the physiology of acute nociception and the pathophysiology of chronic pain.
Positive_regulation (induces) of BST in neuronal associated with nociception, pain and lasting pain
2) Confidence 0.39 Published 2008 Journal Prog. Neuropsychopharmacol. Biol. Psychiatry Section Abstract Doc Link 18164529 Disease Relevance 0.70 Pain Relevance 0.60
Therefore the aims of this study were: (i). to study the possible involvement of dopaminergic fibre terminals in stress-induced activation of BST perikarya; (ii). to investigate whether Met-enkephalin-immunoreactive neurons are recruited by acute volumen/osmotic challenge; and (iii). to demonstrate synaptic interactions between Met-enkephalin-ir neurons and fibre terminals immunopositive for dopamine or noradrenaline in the anterolateral division of the BST.
Spec (investigate) Positive_regulation (activation) of BST in neurons associated with stress, dopamine, noradrenaline and enkephalin
3) Confidence 0.37 Published 2002 Journal Eur. J. Neurosci. Section Abstract Doc Link 12372018 Disease Relevance 0.60 Pain Relevance 0.72
As TH is involved in the synthesis of DA, these data indicate that the BST and CeA are more heavily innervated by DA than the mPOA and VMH.
Positive_regulation (innervated) of BST associated with dopamine and amygdala
4) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.07 Pain Relevance 0.63
The L-ENKI fibers from the Ce reach the BST via two pathways; one from the venral amygdalofugal pathway (VA), which terminate in the ventral subdivision of the BST pars lateralis (BSTL), and the other from the stria terminalis (ST), which terminates in the lateral subdivision of the BSTL, because accumulation of L-ENKI structures appeared in the axons of these two systems on the amygdaloid side, transection or destruction of the ST alone caused only a slight reduction of ENKI fibers in the lateral subdivision of the BSTL ipsilaterally and transection or destruction of VA alone markedly reduced the number of L-ENKI fibers in the ventral subdivision of the ipsilateral BSTL.
Positive_regulation (reach) of BST in lateral
5) Confidence 0.10 Published 1987 Journal Exp Brain Res Section Abstract Doc Link 3549348 Disease Relevance 0 Pain Relevance 0.16
In rat models of schizophrenia, rats with brain lesions to induce deficits in prepulse inhibition of the startle reflex, blood perfusion is increased in several brain areas including the BST.159 In both rats and mice, CRH reduces prepulse inhibition associated with schizophrenia.160,161 Upregulation of CRH by lipopolysaccharide injection in pregnant rats indicates activation of the fetal stress axis described above as probably involved in schizophrenia.162
Positive_regulation (increased) of BST in brain associated with stress and schizophrenia
6) Confidence 0.02 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.87 Pain Relevance 0.06

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