INT37541

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Context Info
Confidence 0.77
First Reported 1986
Last Reported 2010
Negated 2
Speculated 6
Reported most in Body
Documents 113
Total Number 121
Disease Relevance 68.54
Pain Relevance 11.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SPP1) extracellular region (SPP1) cell adhesion (SPP1)
cytoplasm (SPP1)
Anatomy Link Frequency
lung 7
epithelial cells 6
plasma 3
osteoblast 3
connective tissue 3
SPP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 1179 100.00 Very High Very High Very High
metalloproteinase 593 100.00 Very High Very High Very High
chemokine 13 100.00 Very High Very High Very High
Chronic pancreatitis 20 99.84 Very High Very High Very High
Inflammation 323 99.30 Very High Very High Very High
Mechanotransduction 56 98.74 Very High Very High Very High
cytokine 209 97.96 Very High Very High Very High
Multiple sclerosis 560 97.36 Very High Very High Very High
rheumatoid arthritis 233 97.12 Very High Very High Very High
medulla 5 97.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Prostate Cancer 1812 100.00 Very High Very High Very High
Metastasis 1224 100.00 Very High Very High Very High
Pulmonary Fibrosis 1043 100.00 Very High Very High Very High
Osteoporosis 221 100.00 Very High Very High Very High
Atherosclerosis 45 100.00 Very High Very High Very High
Respiratory Syncytial Virus 464 99.88 Very High Very High Very High
Injury 663 99.84 Very High Very High Very High
Pancreatitis 20 99.84 Very High Very High Very High
Skin Cancer 208 99.76 Very High Very High Very High
Fibrosis 174 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Localization and expression of osteopontin in the rotator cuff tendons in patients with calcifying tendinitis.
Gene_expression (expression) of osteopontin in tendons associated with tendinopathy
1) Confidence 0.77 Published 2001 Journal Virchows Arch. Section Title Doc Link 11469694 Disease Relevance 0.43 Pain Relevance 0.15
We previously reported that dental pulp cells produced osteopontin in vitro.
Gene_expression (produced) of osteopontin in dental pulp
2) Confidence 0.77 Published 2001 Journal J Endod Section Abstract Doc Link 11485265 Disease Relevance 0.44 Pain Relevance 0.07
Taken together, the present findings suggest that osteopontin produced by dental pulp cells is possibly associated with calcification of the pulp stone matrix.
Gene_expression (produced) of osteopontin in dental pulp associated with calcification
3) Confidence 0.77 Published 2001 Journal J Endod Section Abstract Doc Link 11485265 Disease Relevance 0.55 Pain Relevance 0.06
Osteopontin expression was detected in acinar or ductal cells in all 11 cases of chronic calcifying pancreatitis, whereas in 5 of 9 CP cases without pancreatic stones there was no expression of osteopontin in acinar or ductal cells.
Neg (no) Gene_expression (expression) of osteopontin
4) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
Osteopontin expression in chronic pancreatitis.
Gene_expression (expression) of Osteopontin associated with chronic pancreatitis
5) Confidence 0.77 Published 2002 Journal Pancreas Section Title Doc Link 12142743 Disease Relevance 0.20 Pain Relevance 0.20
Osteopontin expression was detected in acinar or ductal cells in all 11 cases of chronic calcifying pancreatitis, whereas in 5 of 9 CP cases without pancreatic stones there was no expression of osteopontin in acinar or ductal cells.
Gene_expression (expression) of Osteopontin
6) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
We used reverse transcription polymerase chain reaction and reverse transcription in situ polymerase chain reaction to evaluate osteopontin mRNA expression and immunohistochemical staining to evaluate osteopontin-producing cells.
Gene_expression (expression) of osteopontin mRNA
7) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
We used reverse transcription polymerase chain reaction and reverse transcription in situ polymerase chain reaction to evaluate osteopontin mRNA expression and immunohistochemical staining to evaluate osteopontin-producing cells.
Gene_expression (producing) of osteopontin
8) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
Osteopontin mRNA expression was observed in chronic calcifying pancreatitis samples but not in normal pancreas tissues.
Gene_expression (expression) of Osteopontin mRNA in pancreas
9) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
The data revealed a high incidence of osteopontin expression in chronic calcifying pancreatitis in comparison with its expression in CP without stones (p = 0.0081).
Gene_expression (expression) of osteopontin
10) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
AIMS: Osteopontin expression is related to urinary stone formation and several diseases associated with calcification such as atherosclerosis, breast cancer, and meningioma.
Gene_expression (expression) of Osteopontin
11) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
RESULTS: No expression of osteopontin was seen in normal pancreas cells.
Gene_expression (expression) of osteopontin in pancreas
12) Confidence 0.77 Published 2002 Journal Pancreas Section Body Doc Link 12142743 Disease Relevance 0 Pain Relevance 0
This is also supported by the colocalization of MMP-7 and osteopontin in IPF epithelial cells, and by the computational relationship of the expression levels of osteopontin and MMP-7.
Gene_expression (expression) of osteopontin in epithelial cells associated with fibrosis
13) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.69 Pain Relevance 0.29
We observed that in human IPF lungs, hyperplastic alveolar epithelial cells seemed to be a source of osteopontin, which is consistent with the findings of Berman et al. [15,16].
Gene_expression (source) of osteopontin in lungs associated with fibrosis and hyperplasia
14) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 1.09 Pain Relevance 0.42
Osteopontin expression levels were higher in most IPF lungs than in any control lung (Figure 1B).


Gene_expression (expression) of Osteopontin in lung associated with fibrosis
15) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.79 Pain Relevance 0.40
We demonstrated that osteopontin is highly expressed in IPF lungs, and that it is primarily expressed by hyperplastic alveolar epithelial cells.
Gene_expression (expressed) of osteopontin in epithelial cells associated with fibrosis and hyperplasia
16) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.84 Pain Relevance 0.35
In experimental lung fibrosis it has been suggested that osteopontin produced by alveolar macrophages functions as a fibrogenic cytokine [15,16].
Gene_expression (produced) of osteopontin in alveolar macrophages associated with fibrosis, pulmonary fibrosis and cytokine
17) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.97 Pain Relevance 0.36
Also, osteopontin expression is increased in the myocardium after myocardial infarction, and the lack of this mediator is associated with decreased collagen accumulation [25].
Gene_expression (expression) of osteopontin in myocardium associated with myocardial infarction
18) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.67 Pain Relevance 0.24
The integrin receptors for osteopontin are widely expressed in lung epithelial cells and fibroblasts [47], but a change in their repertoire has not been reported yet with IPF.
Gene_expression (expressed) of osteopontin in fibroblasts associated with fibrosis
19) Confidence 0.77 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1198037 Disease Relevance 0.62 Pain Relevance 0.31
It has been postulated that metastasis to specific target organs may require not only expression of SPP1 but an additional set of signaling molecules that promote metastasis to the specific organ.
Gene_expression (expression) of SPP1 associated with metastasis
20) Confidence 0.71 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1865555 Disease Relevance 1.41 Pain Relevance 0.04

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