INT3755

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Context Info
Confidence 0.40
First Reported 1975
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 8.99
Pain Relevance 8.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GBE1) generation of precursor metabolites and energy (GBE1) small molecule metabolic process (GBE1)
transferase activity, transferring glycosyl groups (GBE1) carbohydrate metabolic process (GBE1)
Anatomy Link Frequency
leucocytes 2
livers 1
skeletal muscle 1
GBE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 24 100.00 Very High Very High Very High
Paracetamol 70 99.98 Very High Very High Very High
cINOD 13 99.98 Very High Very High Very High
antiepileptic Drug 1 99.08 Very High Very High Very High
anticonvulsant 2 98.92 Very High Very High Very High
Action potential 24 97.76 Very High Very High Very High
anesthesia 11 97.72 Very High Very High Very High
action potential duration 46 97.40 Very High Very High Very High
fortral 1 97.00 Very High Very High Very High
Osteoarthritis 3 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 26 100.00 Very High Very High Very High
Toxicity 15 99.44 Very High Very High Very High
Myocardial Infarction 5 99.44 Very High Very High Very High
Disorders Of Creatine Metabolism 13 99.04 Very High Very High Very High
Hypocalcemia 7 97.80 Very High Very High Very High
Hypoxia 8 97.60 Very High Very High Very High
Congenital Anomalies 4 97.12 Very High Very High Very High
Osteoarthritis 3 96.96 Very High Very High Very High
Emergencies 1 96.24 Very High Very High Very High
Rheumatoid Arthritis 2 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This effect presumably is mediated through enzyme induction, resulting from inhaled polycyclic aromatic hydrocarbons.
Positive_regulation (induction) of enzyme
1) Confidence 0.40 Published 1982 Journal Drug Intell Clin Pharm Section Abstract Doc Link 7173046 Disease Relevance 0.41 Pain Relevance 0.49
A possible role of enzyme induction in hepatic and hepatorenal failure following, fluroxene anesthesia is suggested by recent studies in the monkey, which demonstrate that pretreatment with phenobarbital results in increased production of a toxic metabolite and conversion of a well tolerated anesthesia to a rapidly lethal one.
Spec (possible) Positive_regulation (induction) of enzyme associated with anesthesia
2) Confidence 0.40 Published 1975 Journal Acta Anaesthesiol Belg Section Abstract Doc Link 1231480 Disease Relevance 0.26 Pain Relevance 0.49
Although there were no significant abdominal signs, serological examinations demonstrated a marked increase of pancreatic enzyme activity.
Positive_regulation (increase) of enzyme
3) Confidence 0.40 Published 2000 Journal Hiroshima J. Med. Sci. Section Abstract Doc Link 10824463 Disease Relevance 0.79 Pain Relevance 0.06
The principal methods used for the assessment of enzyme induction and enzyme inhibition are measurement of the pharmacokinetics of a model compound (probe drug), analysis of drug metabolism in vitro, and determination of changes in the disposition of, and endogenous substrate for, the enzyme of interest. 2.
Positive_regulation (induction) of enzyme
4) Confidence 0.32 Published 1990 Journal Xenobiotica Section Abstract Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.07
At present it is difficult to assess the toxicological implications of enzyme induction and inhibition in man.
Positive_regulation (induction) of enzyme
5) Confidence 0.32 Published 1990 Journal Xenobiotica Section Abstract Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.08
Assessment of enzyme induction and enzyme inhibition in humans: toxicological implications.
Positive_regulation (induction) of enzyme
6) Confidence 0.32 Published 1990 Journal Xenobiotica Section Title Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.08
Measurement of the excretion of metabolites of cortisol and oestradiol, which are endogenous substrates for cytochrome P450 IIIA enzymes, provides a non-invasive means of assessing enzyme induction or inhibition. 3.
Positive_regulation (induction) of enzyme
7) Confidence 0.32 Published 1990 Journal Xenobiotica Section Abstract Doc Link 2275213 Disease Relevance 0 Pain Relevance 0.09
Microsomal enzyme induction is complex.
Positive_regulation (induction) of enzyme
8) Confidence 0.32 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6359860 Disease Relevance 0.70 Pain Relevance 0.83
It has been assumed that this sensitivity in chronic alcoholics is due to microsomal enzyme induction with enhanced metabolic activation of acetaminophen.
Positive_regulation (induction) of enzyme associated with paracetamol
9) Confidence 0.21 Published 1983 Journal Am. J. Med. Section Abstract Doc Link 6359860 Disease Relevance 0.69 Pain Relevance 0.84
He was diagnosed as having acute myocardial infarction indicated by abnormal ECG, elevated serum enzyme and characteristic signs of echocardiography.
Positive_regulation (elevated) of enzyme associated with myocardial infarction
10) Confidence 0.18 Published 1990 Journal Kokyu To Junkan Section Abstract Doc Link 2371461 Disease Relevance 0.88 Pain Relevance 0.22
Irreversible binding is increased by microsomal enzyme induction and by anaerobic conditions.
Positive_regulation (induction) of enzyme
11) Confidence 0.18 Published 1977 Journal Environ Health Perspect Section Abstract Doc Link PMC1475353 Disease Relevance 0.18 Pain Relevance 0.52
Since GBE is a mixture of its constituents, the total response to GBE would be a result of complex interactions with the constituents.
Positive_regulation (response) of GBE
12) Confidence 0.09 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0 Pain Relevance 0.12
The mechanisms of the therapeutic effectiveness of GBE are expected to be extremely complex, because of the large number of its constituent substances (6,8).
Positive_regulation (effectiveness) of GBE
13) Confidence 0.09 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC538515 Disease Relevance 0.11 Pain Relevance 0.37
Flurbiprofen, fenoprofen, ibuprofen, naproxen, ketoprofen and suprofen stimulated the activity of the human enzyme (1.5-2.4-fold) at low concentrations of less than 20-100 microM, whereas at higher concentrations they inhibited the activity.
Positive_regulation (stimulated) of enzyme
14) Confidence 0.09 Published 1998 Journal Biol. Pharm. Bull. Section Abstract Doc Link 9853403 Disease Relevance 0.16 Pain Relevance 0.17
The increase in enzyme activity at lower acetaminophen concentrations is accounted for by the increased turnover of compounds II and III to native enzyme, while the decline at higher acetaminophen concentrations is explained by the competition of acetaminophen with Cl- for compound I.
Positive_regulation (increase) of enzyme associated with paracetamol
15) Confidence 0.08 Published 1993 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.67
Interaction of acetaminophen with myeloperoxidase intermediates: optimum stimulation of enzyme activity.
Positive_regulation (stimulation) of enzyme associated with paracetamol
16) Confidence 0.08 Published 1993 Journal Arch. Biochem. Biophys. Section Title Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.55
Using steady-state kinetics on the chlorination of monochlorodimedon to measure the activity of myeloperoxidase, our study reveals that acetaminophen stimulates the chlorinating activity of the enzyme and optimum stimulation is achieved at about 30 microM.
Positive_regulation (stimulates) of enzyme associated with paracetamol
17) Confidence 0.08 Published 1993 Journal Arch. Biochem. Biophys. Section Abstract Doc Link 8396889 Disease Relevance 0 Pain Relevance 0.61
The identification of high levels of an inflammatory enzyme, phospholipase A2, in lumbar herniated and degenerative discs presents the basis for a direct inflammogenic capability of lumbar discs, separate from a immunologic mechanism.
Positive_regulation (levels) of enzyme associated with inflammation
18) Confidence 0.08 Published 1995 Journal Spine Section Abstract Doc Link 7502140 Disease Relevance 0.68 Pain Relevance 0.39
The enzyme was most active in the neutral region with Ala-pNA as substrate, and the activity was increased about 20-fold in the presence of some -SH compounds.
Positive_regulation (active) of enzyme
19) Confidence 0.04 Published 1987 Journal Biochem. Med. Metab. Biol. Section Abstract Doc Link 3593594 Disease Relevance 0 Pain Relevance 0.05
After five doses, bosentan levels fell, possibly because of enzyme induction, and protection was no longer evident.
Spec (possibly) Positive_regulation (induction) of enzyme
20) Confidence 0.04 Published 1999 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 10233186 Disease Relevance 0 Pain Relevance 0

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