INT3758

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Context Info
Confidence 0.78
First Reported 1975
Last Reported 2011
Negated 5
Speculated 7
Reported most in Body
Documents 326
Total Number 334
Disease Relevance 184.65
Pain Relevance 38.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
urine 18
blood 15
hepatocytes 14
liver 14
plasma 14
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 368 100.00 Very High Very High Very High
carbamazepine 70 100.00 Very High Very High Very High
gABA 5 100.00 Very High Very High Very High
ischemia 99 99.98 Very High Very High Very High
intrathecal 5 99.98 Very High Very High Very High
spinal inflammation 64 99.92 Very High Very High Very High
addiction 36 99.92 Very High Very High Very High
anesthesia 121 99.84 Very High Very High Very High
Inflammatory marker 28 99.84 Very High Very High Very High
Inflammation 1682 99.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 2652 100.00 Very High Very High Very High
Injury 901 100.00 Very High Very High Very High
Pressure And Volume Under Development 710 100.00 Very High Very High Very High
Cirrhosis 477 100.00 Very High Very High Very High
Fever 461 100.00 Very High Very High Very High
Albuminuria 407 100.00 Very High Very High Very High
Necrosis 173 100.00 Very High Very High Very High
Burns 167 100.00 Very High Very High Very High
Body Weight 162 100.00 Very High Very High Very High
Coagulation Disorder 89 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Concentrations of 0.8 mM morphine and heroin, 0.4 mM meperidine, and 0.005 mM methadone inhibited the albumin synthesis by about 50% after 24 h of pretreatment.
Gene_expression (synthesis) of albumin associated with methadone and morphine
1) Confidence 0.78 Published 1987-1988 Journal Mol Toxicol Section Abstract Doc Link 3509697 Disease Relevance 0.16 Pain Relevance 1.21
The inverse correlation between body weight index and albumin synthesis in cancer patients supports the possibility of a compensatory enhanced albumin synthesis in these metabolically affected patients.
Gene_expression (synthesis) of albumin in body associated with body weight and cancer
2) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.22 Pain Relevance 0.17
Lower levels of serum albumin were found to be associated with poor survival in all studies.
Gene_expression (levels) of serum albumin
3) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.25 Pain Relevance 0
Lower levels of serum albumin were associated with poor survival in all studies.
Gene_expression (levels) of serum albumin
4) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.66 Pain Relevance 0
The lower serum albumin concentration may be due to the production of cytokines such as IL-6, which modulate the production of albumin by hepatocytes [33].
Gene_expression (production) of albumin in hepatocytes associated with cytokine
5) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.29 Pain Relevance 0.23
In the later stages of disease, malnutrition and inflammation suppress albumin synthesis [30].
Gene_expression (synthesis) of albumin associated with appetite loss, inflammation and disease
6) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.19 Pain Relevance 0.21
Malnutrition and inflammation suppress albumin synthesis [29].
Gene_expression (synthesis) of albumin associated with appetite loss and inflammation
7) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.20 Pain Relevance 0.15
The inverse correlation between body weight index and albumin synthesis in cancer patients supports the possibility of a compensatory enhanced albumin synthesis in these metabolically affected patients.
Gene_expression (synthesis) of albumin in body associated with body weight and cancer
8) Confidence 0.77 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.19 Pain Relevance 0.18
In this most strange affection, the patients over many years habitually produce albumin in their urine without becoming dropsical, and I have noted recently that the kidneys were healthy.
Gene_expression (produce) of albumin in urine
9) Confidence 0.77 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2630042 Disease Relevance 0.35 Pain Relevance 0
Methadone metabolism led to decreased urea and albumin production.
Gene_expression (production) of albumin associated with methadone
10) Confidence 0.77 Published 2010 Journal Tissue Eng Part A Section Abstract Doc Link 19778170 Disease Relevance 0.21 Pain Relevance 1.18
Simultaneously, there is reduced synthesis of binding proteins, such as albumin prealbumin, and transferrin.


Gene_expression (synthesis) of albumin
11) Confidence 0.75 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.25 Pain Relevance 0.05
This was an age before the discovery of bacteria, but inevitably infections predominated, and any of those specific to the kidney or the genito-urinary tract could produce albuminuria: venereal disease with a urethral discharge was a potent source of albumin for example.
Gene_expression (source) of albumin in kidney associated with sexually transmitted diseases, albuminuria and infection
12) Confidence 0.75 Published 2005 Journal Medical History. Supplement Section Body Doc Link PMC2632782 Disease Relevance 2.22 Pain Relevance 0
Interestingly, administration of these cells (derived from human cord blood) into fetal sheep resulted significant human hematopoiesis (up to 5%), hepatic chimerism with > 20% albumin-producing human parenchymal hepatic cells, as well as detection of human cardiomyocytes.
Gene_expression (producing) of albumin in cardiomyocytes associated with hematological disease
13) Confidence 0.75 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796850 Disease Relevance 0.34 Pain Relevance 0
Albumin production was not different between the 3 cell types.
Gene_expression (production) of Albumin
14) Confidence 0.75 Published 2007 Journal Liver Transpl. Section Abstract Doc Link 17394165 Disease Relevance 0.06 Pain Relevance 0.10
TER-alb was calculated and expressed as the percentage disappearance per hour.
Gene_expression (expressed) of TER-alb
15) Confidence 0.74 Published 2005 Journal Crit Care Section Body Doc Link PMC1175929 Disease Relevance 0 Pain Relevance 0
Albumin and urea production remained on a relatively constant level for up to 2-3 weeks.
Gene_expression (production) of Albumin
16) Confidence 0.73 Published 2007 Journal ALTEX Section Abstract Doc Link 17361319 Disease Relevance 0 Pain Relevance 0.51
The classic markers for kidney function16–19 used in this study were the levels of albumin and non-protein nitrogen compounds in the serum and urine, albumin/urinary creatinine ratio, creatinine clearance, the abbreviated Modification of Diet in Renal Disease formula for predictive estimation of glomerular filtration rates and urinary volume.


Gene_expression (levels) of albumin in urine associated with disorders of creatine metabolism and renal disease
17) Confidence 0.72 Published 2011 Journal European Journal of Dentistry Section Body Doc Link PMC3019747 Disease Relevance 0.97 Pain Relevance 0
The mRNA expression levels of albumin and cytochrome P450 (CYP3A29) were determined by RT-PCR method.
Spec (determined) Gene_expression (expression) of albumin
18) Confidence 0.68 Published 2005 Journal Biomed Mater Eng Section Abstract Doc Link 15912001 Disease Relevance 0 Pain Relevance 0.05
After this adaptive period stable levels for DNA content and albumin synthesis were noted; ALAT returned to low values. 4.
Gene_expression (synthesis) of albumin
19) Confidence 0.68 Published 1994 Journal Xenobiotica Section Abstract Doc Link 8017092 Disease Relevance 0 Pain Relevance 0.26
An early culture phase (3 days after isolation) could be described with decreasing DNA content of the cultures, peak values of alanine-amino-transferase (ALAT), and increasing albumin synthesis.
Gene_expression (synthesis) of albumin
20) Confidence 0.68 Published 1994 Journal Xenobiotica Section Abstract Doc Link 8017092 Disease Relevance 0 Pain Relevance 0.24

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