INT37588

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Context Info
Confidence 0.63
First Reported 1981
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.35
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (FAM20B) kinase activity (FAM20B)
Anatomy Link Frequency
cartilage 2
articular cartilage 1
FAM20B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 19 98.56 Very High Very High Very High
cytokine 1 95.12 Very High Very High Very High
Osteoarthritis 4 92.20 High High
Inflammation 2 89.88 High High
diclofenac 2 86.08 High High
aspirin 1 84.88 Quite High
Disease Link Frequency Relevance Heat
Arthritis 3 99.16 Very High Very High Very High
Osteoarthritis 7 97.62 Very High Very High Very High
INFLAMMATION 8 92.60 High High
Alcoholic Liver Cirrhosis 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data indicate that glucocorticoids minimally suppress glycosaminoglycan (GAG) synthesis in nonactivated cultures.
Gene_expression (synthesis) of glycosaminoglycan
1) Confidence 0.63 Published 1981 Journal In Vitro Section Abstract Doc Link 6765898 Disease Relevance 0.18 Pain Relevance 0.14
Therapeutic levels of piroxicam has no effect on cartilage glycosaminoglycan (GAG), collagen or noncollagen protein synthesis by porcine weight bearing articular cartilage explants.
Gene_expression (synthesis) of glycosaminoglycan in articular cartilage
2) Confidence 0.34 Published 1986 Journal J. Rheumatol. Section Abstract Doc Link 3560088 Disease Relevance 0.17 Pain Relevance 0.25
Experiments conducted on explants of normal and osteoarthritic human cartilage have shown that certain NSAIDs at pharmacologic concentrations achievable in man consistently inhibit glycosaminoglycan (GAG) synthesis.
Gene_expression (synthesis) of glycosaminoglycan in cartilage associated with cinod and osteoarthritis
3) Confidence 0.21 Published 1993 Journal Eur J Rheumatol Inflamm Section Abstract Doc Link 7821339 Disease Relevance 0.42 Pain Relevance 0.73
Prostaglandins in human cartilage metabolism.

(1) Human cartilage, both non-arthritic (N) and arthritic, is extremely sensitive to inhibition of glycosaminoglycan (GAG) synthesis by low concentrations of interleukin 1 (IL1).

Gene_expression (synthesis) of glycosaminoglycan in cartilage associated with arthritis
4) Confidence 0.10 Published 1993 Journal J Lipid Mediat Section Title Doc Link 8357988 Disease Relevance 0.58 Pain Relevance 0.47

General Comments

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