INT37590

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Context Info
Confidence 0.54
First Reported 1986
Last Reported 2010
Negated 2
Speculated 4
Reported most in Body
Documents 15
Total Number 20
Disease Relevance 9.40
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (COL7A1) cell adhesion (COL7A1)
Anatomy Link Frequency
chondrocyte 1
cartilage 1
tendons 1
fissures 1
articular cartilage 1
COL7A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 87 98.00 Very High Very High Very High
cINOD 13 97.84 Very High Very High Very High
fibrosis 13 97.56 Very High Very High Very High
aspirin 11 97.00 Very High Very High Very High
Arthritis 12 94.76 High High
c fibre 4 93.52 High High
backache 2 93.44 High High
Neuropeptide 4 91.44 High High
substance P 2 90.52 High High
unmyelinated 2 88.32 High High
Disease Link Frequency Relevance Heat
Injury 103 100.00 Very High Very High Very High
Adenocarcinoma 9 99.32 Very High Very High Very High
Fibrosis 24 99.16 Very High Very High Very High
Aging 42 99.04 Very High Very High Very High
Corneal Disease 16 98.92 Very High Very High Very High
Disease 40 98.56 Very High Very High Very High
Scoliosis 2 98.08 Very High Very High Very High
Osteoarthritis 91 98.00 Very High Very High Very High
INFLAMMATION 31 97.28 Very High Very High Very High
Cancer 156 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Extrinsic factors, notably solar radiation, damage the dermis, with affects on collagen and elastic fibres (Demas and Braun 2001).
Regulation (affects) of collagen in dermis
1) Confidence 0.54 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695163 Disease Relevance 0.63 Pain Relevance 0.04
We addressed the question whether the alterations in collagen content in lung adenocarcinomas reported in previous studies result from dysregulation of gelatinolytic activity and whether the activity is altered by acetylsalicylic acid in vitro.
Spec (whether) Regulation (alterations) of collagen in lung associated with adenocarcinoma and aspirin
2) Confidence 0.44 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12044784 Disease Relevance 0.43 Pain Relevance 0.35
This alteration in the crimping behavior of collagen may thus contribute to the underlying tissue changes which culminate in fissures and annual tears in the degenerating disc.


Regulation (alteration) of collagen in fissures
3) Confidence 0.44 Published 2002 Journal BMC Musculoskelet Disord Section Body Doc Link PMC101374 Disease Relevance 0.25 Pain Relevance 0
To date, few studies have examined the effectiveness of collagen cross-linking in treating keratoconus and improving visual acuity.
Spec (examined) Regulation (effectiveness) of collagen associated with corneal disease
4) Confidence 0.44 Published 2008 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2699818 Disease Relevance 0.43 Pain Relevance 0
It showed a statistically significant influence of burst TENS on new collagen production, maturation of newly formed collagen and organisation of collagen.
Regulation (influence) of collagen
5) Confidence 0.42 Published 2005 Journal Acta Orthop Belg Section Abstract Doc Link 16035709 Disease Relevance 0.07 Pain Relevance 0.30
Influence of burst TENS stimulation on collagen formation after Achilles tendon suture in man.
Regulation (Influence) of collagen in suture
6) Confidence 0.42 Published 2005 Journal Acta Orthop Belg Section Title Doc Link 16035709 Disease Relevance 0.09 Pain Relevance 0.35
However, all chondroformative processes were unaffected by meloxicam as indicated by a lack of effect on DNA synthesis and on type-II collagen and proteoglycan levels in chondrocyte culture medium and clusters, while acetylsalicylic acid decreased proteoglycan production and cell proliferation.
Regulation (effect) of collagen in chondrocyte associated with aspirin
7) Confidence 0.39 Published 1997 Journal Pharmacology Section Abstract Doc Link 9065961 Disease Relevance 0.21 Pain Relevance 0.53
Therapeutic levels of piroxicam has no effect on cartilage glycosaminoglycan (GAG), collagen or noncollagen protein synthesis by porcine weight bearing articular cartilage explants.
Neg (no) Regulation (effect) of collagen in articular cartilage
8) Confidence 0.33 Published 1986 Journal J. Rheumatol. Section Abstract Doc Link 3560088 Disease Relevance 0.17 Pain Relevance 0.25
Collagen sponges for bone regeneration with rhBMP-2.
Regulation (sponges) of Collagen
9) Confidence 0.33 Published 2003 Journal Adv. Drug Deliv. Rev. Section Title Doc Link 14623404 Disease Relevance 0.19 Pain Relevance 0.09
Changes in collagen cross-linking in degenerative disc disease and scoliosis.
Regulation (Changes) of collagen associated with scoliosis and disease
10) Confidence 0.27 Published 1998 Journal Spine Section Title Doc Link 9854753 Disease Relevance 0.20 Pain Relevance 0.09
In contrast, the collagen metabolism in healthy control tendons seems not to be affected by eccentric training.
Regulation (affected) of collagen in tendons
11) Confidence 0.26 Published 2007 Journal Scand J Med Sci Sports Section Abstract Doc Link 16787448 Disease Relevance 0.16 Pain Relevance 0.09
We carried out the present study to determine the effect of chikungunya on the collagen and connective tissue metabolism in 75 chikungunya-affected people.
Spec (determine) Regulation (effect) of collagen in connective tissue
12) Confidence 0.26 Published 2008 Journal Virol J Section Abstract Doc Link PMC2291039 Disease Relevance 0.81 Pain Relevance 0.10
This loss of vascular supply continues to progress in a near linear fashion for the remainder of the patient's life, leading to long-term, localized deficits in wound healing in these patients.21,22 While most authors suggest that progressive microvascular occlusion is the primary cause of poor wound healing in irradiated tissues, others have suggested that damage to the basal layer of the epidermis may play a major role in chronic radiation damage.18 Another possibility is that radiation may have direct effects on other components of the wound, such as collagen, with vascular damage as a secondary occurrence.15,18,19
Regulation (effects) of collagen in epidermis associated with injury and wound healing
13) Confidence 0.22 Published 2008 Journal Eplasty Section Body Doc Link PMC2206003 Disease Relevance 1.15 Pain Relevance 0
Agents with periodontal regenerative potential regulate cell-mediated collagen lattice contraction in vitro.
Regulation (regulate) of collagen
14) Confidence 0.19 Published 1996 Journal J. Dent. Res. Section Title Doc Link 8675801 Disease Relevance 0.30 Pain Relevance 0.22
OBJECTIVE: To investigate changes in levels of serum cartilage oligomeric matrix protein (COMP) and urine c-telopeptide of type-2 collagen (CTX-II) as markers for cartilage turnover in patients with osteoarthritis (OA) of the knee, in response to muscle strength training in combination with treatment with glucosamine, ibuprofen or placebo.
Spec (investigate) Regulation (changes) of collagen in urine associated with osteoarthritis
15) Confidence 0.15 Published 2010 Journal Osteoarthr. Cartil. Section Abstract Doc Link 19679221 Disease Relevance 0.17 Pain Relevance 0.09
The relationship between collagen and prolidase activity was observed during fibrotic processes, where an increase in prolidase activity was accompanied by increase in tissue collagen deposition.27 The negative effect of free radicals is mediated by degradative agents such as proteolytic enzymes and the last step of collagen degradation is mediated by prolidase.12 Surazynski et al. pointed out that prolidase may also have a role in angiogenesis as prolidase deficiency is associated with angiopathy.13 Oxidative stress resulted in collagen degradation and this process is mediated by prolidase.12 Moreover the degree of severity of oxidative stress is directly related to the inhibition of collagen production, and prolidase is thought to be the target enzyme of this process.28 Yildiz et al. showed that increased serum prolidase activity was significantly associated with the presence and severity of coronary artery disease.29 In accordance with their study we have shown that serum prolidase activity is significantly associated with the presence and severity of vasculogenic ED, and elevated serum prolidase activity may be an independent predictor of ED.10 In addition, it was suggested that hypertension and its duration is associated with increased serum prolidase activity and might be useful as a marker for the follow?
Regulation (activity) of collagen in coronary artery associated with stress, fibrosis, prolidase deficiency, coronary artery disease, erectile dysfunction, vascular disease and hypertension
16) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 0.98 Pain Relevance 0.07
terminals, and has a major role in collagen turnover and cell growth.10,11 The relationship between collagen and prolidase activity was observed during a study of fibrotic processes, where an increase in prolidase activity was accompanied by an increase in tissue collagen deposition.11 The negative effect of free radicals is mediated by degradative agents such as proteolytic enzymes and the final step of collagen degradation is mediated by prolidase.12 Surazynski et al. noted that prolidase may also have a role in angiogenesis since prolidase deficiency is associated with angiopathy.13
Regulation (activity) of collagen associated with fibrosis, prolidase deficiency and vascular disease
17) Confidence 0.06 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC3020342 Disease Relevance 0.68 Pain Relevance 0
Subsequent studies have also suggested that T2 relaxation time measurements are sensitive to the collagen architecture [92, 93].
Regulation (sensitive) of collagen
18) Confidence 0.04 Published 2010 Journal Skeletal Radiol Section Body Doc Link PMC2920421 Disease Relevance 0.31 Pain Relevance 0.16
Obviously therapeutic intervention in order to control both joint cartilage collagen content and bone content have to be considered in OA management.
Regulation (control) of collagen in cartilage associated with osteoarthritis
19) Confidence 0.03 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.80 Pain Relevance 0.36
No

significant change in cellularity or collagen content was

Neg (No) Regulation (change) of collagen
20) Confidence 0.02 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC548804 Disease Relevance 1.38 Pain Relevance 0.04

General Comments

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