INT3760

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Context Info
Confidence 0.70
First Reported 1975
Last Reported 2011
Negated 7
Speculated 2
Reported most in Abstract
Documents 142
Total Number 151
Disease Relevance 87.46
Pain Relevance 26.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB)
DNA binding (ALB) protein complex (ALB) transmembrane transport (ALB)
Anatomy Link Frequency
blood 10
plasma 9
nasal 7
urine 5
liver 2
ALB (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 72 99.98 Very High Very High Very High
Paracetamol 82 99.92 Very High Very High Very High
ischemia 44 99.80 Very High Very High Very High
Morphine 39 99.68 Very High Very High Very High
Infliximab 61 99.64 Very High Very High Very High
Inflammation 434 99.48 Very High Very High Very High
Oxycodone 11 99.42 Very High Very High Very High
fibrosis 87 99.28 Very High Very High Very High
cva 84 99.28 Very High Very High Very High
Chronic pancreatitis 11 99.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 235 100.00 Very High Very High Very High
Adhesions 215 100.00 Very High Very High Very High
Pressure And Volume Under Development 197 100.00 Very High Very High Very High
Metastasis 184 100.00 Very High Very High Very High
Lymphopenia 34 100.00 Very High Very High Very High
Hepatitis C Virus Infection 11 100.00 Very High Very High Very High
Cancer 1075 99.96 Very High Very High Very High
Hypertension 157 99.90 Very High Very High Very High
Weight Loss 120 99.84 Very High Very High Very High
Sepsis 281 99.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, bound fractions of oxycodone and morphine increased with increasing concentrations of both albumin and AAG.
Positive_regulation (increasing) of albumin associated with oxycodone and morphine
1) Confidence 0.70 Published 1993 Journal Ther Drug Monit Section Abstract Doc Link 8249052 Disease Relevance 0 Pain Relevance 1.32
These data could be clinically relevant, since the drugs examined are used at very high doses in rheumatoid arthritis and related conditions, with plasma levels that could cause significant stabilization of serum albumin and perhaps other proteins.
Positive_regulation (stabilization) of albumin in plasma associated with rheumatoid arthritis
2) Confidence 0.70 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9589803 Disease Relevance 0.22 Pain Relevance 0.18
A study investigating the prognostic role of serum albumin in patients with ovarian cancer treated in an integrative cancer treatment setting found that every one gm/dL increase in serum albumin was associated with a RR of 0.39 (95% CI: 0.29 to 0.53; p < 0.001) [77].
Positive_regulation (increase) of serum albumin associated with ovarian cancer and immunotherapy of cancer
3) Confidence 0.69 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.29 Pain Relevance 0.05
Leukocyte counts or albumin and lysozyme levels were not significantly increased after administration of 1 microg of capsaicin at any time point.
Neg (not) Positive_regulation (increased) of albumin in Leukocyte
4) Confidence 0.69 Published 1997 Journal J. Allergy Clin. Immunol. Section Body Doc Link 9389293 Disease Relevance 0.06 Pain Relevance 0
To evaluate whether glandular secretions contribute to the albumin increase in nasal lavage fluids, volunteers with allergic rhinitis were pretreated with atropine or placebo before capsaicin challenge.
Spec (whether) Positive_regulation (increase) of albumin in nasal associated with rhinitis and qutenza
5) Confidence 0.69 Published 1998 Journal J. Appl. Physiol. Section Abstract Doc Link 9475863 Disease Relevance 0.33 Pain Relevance 0.44
Atropine significantly reduced the volume of returned lavage fluids and their lysozyme content but increased their albumin and fibrinogen content.
Positive_regulation (increased) of albumin
6) Confidence 0.69 Published 1998 Journal J. Appl. Physiol. Section Abstract Doc Link 9475863 Disease Relevance 0.34 Pain Relevance 0.75
We have previously shown that capsaicin nasal challenge in subjects with allergic rhinitis produces a dose-dependent increase in the albumin content of nasal lavage fluids.
Positive_regulation (increase) of albumin in nasal associated with rhinitis and qutenza
7) Confidence 0.69 Published 1998 Journal J. Appl. Physiol. Section Abstract Doc Link 9475863 Disease Relevance 0.31 Pain Relevance 0.17
Plasma creatinine concentration did not change, plasma blood urea nitrogen decreased significantly, and significant increases in urine glucose, protein, and albumin occurred similarly in all groups.
Positive_regulation (increases) of albumin in blood
8) Confidence 0.68 Published 2000 Journal Anesthesiology Section Body Doc Link 11149433 Disease Relevance 0 Pain Relevance 0
Bradykinin nasal challenge caused a mean maximal increase in albumin levels in recovered nasal lavages of 11.5, 13.0, 12.2 and 12.3 times of baseline levels on the placebo, terfenadine, ipratropium bromide and terfenadine plus ipratroprium bromide pretreatment days respectively.
Positive_regulation (increase) of albumin in nasal associated with bradykinin
9) Confidence 0.68 Published 1992 Journal Clin. Exp. Allergy Section Abstract Doc Link 1387041 Disease Relevance 0.16 Pain Relevance 0.43
Leukospermia was also significantly coupled to alterations of the seminal plasma protein composition (increase of the albumin concentration, decrease of prostatic markers and other anomalies).
Positive_regulation (increase) of albumin in plasma
10) Confidence 0.68 Published 1988 Journal Acta Eur. Fertil. Section Abstract Doc Link 3223195 Disease Relevance 0.63 Pain Relevance 0.18
The protein level in the nasal lavage fluid increased from 190 to 1275 microg/ml 24 h after the challenge with an increase of relative albumin level from 24% to 40% at 24 h.
Positive_regulation (increase) of albumin in nasal
11) Confidence 0.68 Published 1996 Journal Allergy Section Abstract Doc Link 9020419 Disease Relevance 0.27 Pain Relevance 0.20
IMPLICATIONS: Sevoflurane delivered in a 3% concentration with a fresh gas flow of 1 L/min for 4 h generated an average maximal Compound A concentration of 39 ppm but did not result in any significant increase in sensitive markers of renal function or injury, including urinary protein, albumin, glucose, and alpha- and pi-glutathione-S-transferase.
Positive_regulation (increase) of albumin associated with injury
12) Confidence 0.58 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9495434 Disease Relevance 0.33 Pain Relevance 0.36
First, by microsomal incubations of APAP in presence of CPF and/or intact albumin, in vitro reference adducts were generated to determine the mass spectrometric characteristics of the expected CPF adducts and to confirm their formation on pronase E digestion of the alkylated protein.
Positive_regulation (presence) of albumin associated with paracetamol
13) Confidence 0.50 Published 2007 Journal Drug Metab. Dispos. Section Abstract Doc Link 17510247 Disease Relevance 0.07 Pain Relevance 0.43
Furthermore, the HPLC assay allowed the examination of a number of coloured substances, including bilirubin, which appeared to be a strong stabilizer of its physiological carrier, albumin.
Positive_regulation (stabilizer) of albumin
14) Confidence 0.50 Published 1998 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 9589803 Disease Relevance 0.20 Pain Relevance 0.22
Natural hydrophobic substances like bile salts (cholate, deoxycholate, chenodeoxycholate, lithocholate and their conjugates with glycine and taurine), fatty acids (caprylic, capric, lauric, myristic, palmitic, stearic, oleic, linoleic, arachidonic, eicosapentaenoic and docosahexaenoic acid) were much more active (EC50 approximately 10(-4)-10(-5) M) than selected amino acids (EC50 > 10(-2) M) and inorganic salts (EC50 approximately 10(-1) M) in inhibiting heat-induced denaturation of human serum albumin in vitro.
Positive_regulation (heat-induced) of serum albumin in bile associated with bile
15) Confidence 0.50 Published 1999 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 10082322 Disease Relevance 0.14 Pain Relevance 0.11
Our findings demonstrate that the enhanced albumin passage through the wall of the microvasculature characteristically found in long-term Type 1 diabetic patients with clinical microangiopathy is pressure-dependent to a large extent.
Positive_regulation (enhanced) of albumin associated with diabetes mellitus
16) Confidence 0.50 Published 1985 Journal Diabetologia Section Abstract Doc Link 4085693 Disease Relevance 0.68 Pain Relevance 0.16
All studies found pretreatment serum albumin to be prognostic of cancer survival.


Positive_regulation (pretreatment) of serum albumin associated with cancer
17) Confidence 0.50 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.53 Pain Relevance 0
Alternatively, tumor necrosis factor may increase the permeability of the microvasculature, thus allowing an increased transcapillary passage of albumin.
Positive_regulation (increased) of albumin associated with necrosis and cancer
18) Confidence 0.50 Published 2010 Journal Nutr J Section Body Doc Link PMC3019132 Disease Relevance 1.37 Pain Relevance 0.22
Inhibition of heat-induced denaturation of albumin by nonsteroidal antiinflammatory drugs (NSAIDs): pharmacological implications.
Positive_regulation (heat-induced) of albumin associated with inflammation and cinod
19) Confidence 0.50 Published 2001 Journal Arch. Pharm. Res. Section Title Doc Link 11339635 Disease Relevance 0.38 Pain Relevance 0.42
Since we speculated that these drugs could also act by protecting endogenous proteins against denaturation, we evaluated their effect on heat-induced denaturation human serum albumin (HSA) in comparison with several fatty acids which are known to be potent stabilizers of this protein.
Positive_regulation (heat-induced) of serum albumin
20) Confidence 0.50 Published 2001 Journal Arch. Pharm. Res. Section Abstract Doc Link 11339635 Disease Relevance 0.34 Pain Relevance 0.40

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