INT37618

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 50
Total Number 57
Disease Relevance 33.88
Pain Relevance 11.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col2a1) extracellular region (Col2a1) proteinaceous extracellular matrix (Col2a1)
cytoplasm (Col2a1)
Anatomy Link Frequency
chondrocytes 7
cartilage 6
intervertebral space 2
tendon 2
skeletal muscle 2
Col2a1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 555 100.00 Very High Very High Very High
metalloproteinase 178 100.00 Very High Very High Very High
Arthritis 1064 99.98 Very High Very High Very High
Osteoarthritis 1299 99.78 Very High Very High Very High
addiction 7 96.76 Very High Very High Very High
imagery 97 95.48 Very High Very High Very High
cytokine 290 95.28 Very High Very High Very High
chemokine 58 94.84 High High
Inflammation 395 93.60 High High
agonist 8 89.92 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 562 100.00 Very High Very High Very High
Arthritis 1163 99.98 Very High Very High Very High
Targeted Disruption 31 99.88 Very High Very High Very High
Osteoarthritis 1303 99.78 Very High Very High Very High
Adhesions 146 99.64 Very High Very High Very High
Immunization 73 99.60 Very High Very High Very High
Sprains And Strains 184 98.28 Very High Very High Very High
Hypertrophy 66 97.84 Very High Very High Very High
Intervertebral Disk Degeneration 32 97.84 Very High Very High Very High
Death 58 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col2a1 in ligament
1) Confidence 0.70 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of these marker genes confirmed the accuracy of the dissection protocol since the relative levels of Myod1 expression in the Achilles tendon and spinal ligament were negligible as was the expression of Col2a1 in the skeletal muscle.
Gene_expression (expression) of Col2a1 in skeletal muscle
2) Confidence 0.70 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.07 Pain Relevance 0
With the exception of Col2CTX, all assays were conducted at TNO (Leiden, The Netherlands).


Neg (exception) Gene_expression (exception) of Col2
3) Confidence 0.65 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212578 Disease Relevance 0 Pain Relevance 0.04
Associated with the arthritis is the development of cytotoxicity to mouse chondrocytes and, in some animals, of rheumatoid factor, immune deposits in joint tissues and kidneys, and the production of autoantibodies to mouse type II collagen.
Gene_expression (production) of type II collagen in joint associated with arthritis
4) Confidence 0.46 Published 1987 Journal Arthritis Rheum. Section Abstract Doc Link 3566822 Disease Relevance 0.71 Pain Relevance 0.33
Histochemical analysis revealed that collagen type II was more expressed in hyaline tissue (very intense), whereas collagen type I was predominant in fibrocartilage (very intense) (Figures 1c,d, 2c,d and 3c,d).
Gene_expression (expressed) of collagen type II in fibrocartilage
5) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656234 Disease Relevance 0.09 Pain Relevance 0
RNA analysis and immunohistochemistry reveal that cells sustain the expression of cartilage genes and proteins, such as collagen type II, type IX, and type X, aggrecan and sox 9 [13,14].
Gene_expression (expression) of collagen type II in cartilage
6) Confidence 0.45 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656234 Disease Relevance 0 Pain Relevance 0.04
However, ISH revealed that whereas sox9 and col2a was present in chordoblasts from the non-deformed stage, runx2 and col1a was only detected in fused samples, when intervertebral space was severely narrowed.
Gene_expression (present) of col2a in intervertebral space
7) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.18 Pain Relevance 0
Furthermore, col2a was expressed at the growth zone of the vertebral body endplates in both intermediate and fused samples (Figure 6F, G).
Gene_expression (expressed) of col2a in vertebral body
8) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0 Pain Relevance 0
During trans-chondroid ossification, chondrocytes are found to express both col1 and col2 [24].
Gene_expression (express) of col2 in chondrocytes
9) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0.32 Pain Relevance 0
Positive staining of col2a in the notochord became stronger as intervertebral space narrowed down (Figure 6F, G).
Gene_expression (staining) of col2a in intervertebral space
10) Confidence 0.35 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2909226 Disease Relevance 0 Pain Relevance 0
Quantitative RT-PCR analysis revealed a significant increase of AGN and COL2 expression in both T-MPCs and BM-MPCs, although the increase in COL2 expression was significantly lower in T-MPCs pellets compared with BM-MPCs (Figure 3b).


Gene_expression (expression) of COL2
11) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.08 Pain Relevance 0
Quantitative RT-PCR analysis revealed a significant increase of AGN and COL2 expression in both T-MPCs and BM-MPCs, although the increase in COL2 expression was significantly lower in T-MPCs pellets compared with BM-MPCs (Figure 3b).


Gene_expression (expression) of COL2
12) Confidence 0.30 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575631 Disease Relevance 0.08 Pain Relevance 0
Type II collagen neo-synthesis and degradation
Gene_expression (synthesis) of Type II collagen
13) Confidence 0.27 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.91 Pain Relevance 0
Another explanation for this discrepancy is that different MMPs may be responsible for aggrecan and collagen type II cleavage.
Gene_expression (cleavage) of collagen type II in cleavage associated with metalloproteinase
14) Confidence 0.27 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.20 Pain Relevance 0.33
Interestingly, in this study, DBA/1 mice maintained a high level of collagen type II neo-synthesis and a low collagen catabolic activity for 8 weeks after injury.
Gene_expression (synthesis) of collagen type II associated with injury
15) Confidence 0.24 Published 2009 Journal Osteoarthritis Cartilage Section Body Doc Link PMC2706394 Disease Relevance 0.50 Pain Relevance 0.07
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col2a1 in tendon
16) Confidence 0.24 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
The expression levels of Col1a1 (a positive marker for tendon, ligament and skeletal muscle), Col2a1 (a negative marker for the same tissues), Myod1 (a positive marker for skeletal muscle and a negative marker for tendon) and Comp were determined at 3 weeks of age by quantitative real-time PCR (Supplementary Material, Table S1).
Spec (determined) Gene_expression (expression) of Col2a1 in skeletal muscle
17) Confidence 0.24 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2792148 Disease Relevance 0.27 Pain Relevance 0
g/mL) in the presence or absence of type II collagen or the synthetic collagen fragment CII256-270 (both at 50 ?
Gene_expression (presence) of type II collagen
18) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 0.19 Pain Relevance 0.12
Pre-clinical assessment of therapeutics for RA has relied largely on murine models of arthritis, particularly the CIA model, in which mice are immunised with heterologous type II collagen in complete Freund's adjuvant (CFA) [5].
Gene_expression (immunised) of type II collagen associated with rheumatoid arthritis and arthritis
19) Confidence 0.22 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 2.14 Pain Relevance 0.67
Furthermore, immunisation of transgenic mice expressing RA-associated HLA-DR4/DR1 haplotypes with type II collagen results in arthritis [1,2] and reveals a single immunodominant epitope (amino acids 261 to 273) that overlaps the immunodominant epitope in DBA/1 mice with collagen-induced arthritis (CIA) (256 to 270) [1,3].
Gene_expression (expressing) of type II collagen associated with targeted disruption, immunization, rheumatoid arthritis and arthritis
20) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212575 Disease Relevance 1.71 Pain Relevance 0.64

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