INT37652

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 29
Total Number 31
Disease Relevance 9.09
Pain Relevance 4.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Pgr) nucleolus (Pgr) nucleus (Pgr)
enzyme binding (Pgr) cytoplasm (Pgr)
Anatomy Link Frequency
heart 3
anterior pituitary 3
mammary gland 2
POA 2
myometrium 1
Pgr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Arthritis 8 99.84 Very High Very High Very High
antagonist 59 99.52 Very High Very High Very High
cocaine 37 99.40 Very High Very High Very High
anesthesia 15 99.40 Very High Very High Very High
Dorsal horn neuron 13 99.00 Very High Very High Very High
Inflammation 17 98.28 Very High Very High Very High
palliative 3 98.28 Very High Very High Very High
Delta opioid receptors 2 97.36 Very High Very High Very High
agonist 67 97.34 Very High Very High Very High
anticonvulsant 34 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Arthritis 6 99.84 Very High Very High Very High
Heart Rate Under Development 6 99.80 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 8 99.74 Very High Very High Very High
Repression 1 99.56 Very High Very High Very High
Disease 57 99.28 Very High Very High Very High
Cancer 73 99.00 Very High Very High Very High
Malignant Neoplastic Disease 4 98.78 Very High Very High Very High
INFLAMMATION 13 98.28 Very High Very High Very High
Lordosis 2 98.20 Very High Very High Very High
Hypothermia 2 98.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The acute induction of PR mRNA, and repression (at 6 h) of PPE mRNA by E2 was enhanced by 4-MBC in male and female VMH and female MPO, whereas male MPO exhibited reduced responsiveness of both genes.
Positive_regulation (induction) of PR in MPO associated with repression and urological neuroanatomy
1) Confidence 0.59 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17188730 Disease Relevance 0.54 Pain Relevance 0
For both the rat preproenkephalin gene and the gene for the progesterone receptor, a strong induction by estrogen, tissue specificity of expression and a sex difference in regulation are prominent phenomena.
Positive_regulation (induction) of progesterone
2) Confidence 0.46 Published 1994 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 8043503 Disease Relevance 0 Pain Relevance 0
We also found that injection of BPA significantly increased PR mRNA in the POA and anterior pituitary, while injection of BBP increased PR mRNA in the POA and anterior pituitary, although the increase in the anterior pituitary was not significant.
Positive_regulation (increased) of PR in anterior pituitary
3) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
We also found that injection of BPA significantly increased PR mRNA in the POA and anterior pituitary, while injection of BBP increased PR mRNA in the POA and anterior pituitary, although the increase in the anterior pituitary was not significant.
Positive_regulation (increased) of PR in anterior pituitary
4) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
Northern blot revealed that injection of E(2) resulted in expected changes, i.e., significant increases in PR mRNA in the POA, MBH and anterior pituitary, and in PPE mRNA in the MBH.
Positive_regulation (increases) of PR in MBH
5) Confidence 0.42 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0
Anesthesia mostly was accompanied by an increase of HR and PR and a decrease of CO and SV, whereas BP remained unchanged or somewhat declined.
Positive_regulation (increase) of PR associated with anesthesia
6) Confidence 0.41 Published 1980 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 7436631 Disease Relevance 0.09 Pain Relevance 0.10
RESULTS: With spontaneously beating hearts l-bupivacaine led to a significant decrease in heart rate (to 74% +/- 7% of baseline), +dP/dt (69% +/- 7%), systolic pressure (78% +/- 6%), coronary flow (61% +/- 8%), and to an increase in PR (177% +/- 52%) and QRS intervals (166% +/- 36%).
Positive_regulation (increase) of PR in heart
7) Confidence 0.40 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179268 Disease Relevance 0.07 Pain Relevance 0
Stimulation of PR in mammary epithelial cells is another typical effect of E2, which we observed in the animals treated with both E2 doses and GEN high; however, we counted significantly fewer PR-expressing cells in the E2 high tissues compared with the E2 low tissues.
Positive_regulation (Stimulation) of PR in epithelial cells
8) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.18 Pain Relevance 0
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Positive_regulation (stimulated) of PR in mammary gland
9) Confidence 0.39 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.22 Pain Relevance 0.15
Both solvents produced tachycardia; toluene increased the duration of QRS and specially PR, while benzene decreased P wave duration.
Positive_regulation (increased) of PR associated with heart rate under development
10) Confidence 0.37 Published 1986 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3963933 Disease Relevance 0.28 Pain Relevance 0
Therefore, increased plasma concentrations of PR in arthritis are related to the degree of inflammation.
Positive_regulation (increased) of PR in plasma associated with inflammation and arthritis
11) Confidence 0.32 Published 1995 Journal Drug Metab. Dispos. Section Abstract Doc Link 7736918 Disease Relevance 0.95 Pain Relevance 0.53
In conscious rats, when administered intracerebroventricularly (i.c.v.) in doses of 0.3, 1 and 3 micrograms/kg/min for 30 min, all the three Ca-antagonists induced dose-dependent increases in mean arterial pressure (MAP) and pulse rate (PR), whereas nicardipine administered intravenously (i.v.) caused a decrease in MAP and an increase in PR.
Positive_regulation (increases) of PR associated with antagonist
12) Confidence 0.29 Published 1987 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 3576611 Disease Relevance 0.15 Pain Relevance 0.40
Chlordiazepoxide increased PR responding in both the HG and LG rats, while the selective corticotrophin releasing hormone 1 receptor antagonist R121919 had no effect on cocaine self-administration under the PR schedule.
Positive_regulation (increased) of PR associated with antagonist and cocaine
13) Confidence 0.28 Published 2004 Journal Neuroscience Section Abstract Doc Link 15450359 Disease Relevance 0.31 Pain Relevance 0.44
Therefore, we performed proliferation-specific analyses and determined expression of the progesterone receptor (PR), which is stimulated in the mammary gland after E2 exposure (Tekmal et al. 2005).
Positive_regulation (stimulated) of progesterone receptor in mammary gland
14) Confidence 0.28 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2174401 Disease Relevance 0.22 Pain Relevance 0.15
In addition, estrogens increase the PR immunoreaction in stromal, but not epithelial, cells in ovariectomized (ovx) rats.
Positive_regulation (increase) of PR
15) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0 Pain Relevance 0
In the myometrium PR levels were low in the OvxC group, E2 the last 24 hrs prior to sacrifice increased PR levels, while P treatment had no effect, or when given after 24 hrs of E2 treatment, reduced the effect from E2 stimulation.
Positive_regulation (increased) of PR in myometrium
16) Confidence 0.27 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1586009 Disease Relevance 0.05 Pain Relevance 0
In conscious rats, when administered intracerebroventricularly (i.c.v.) in doses of 0.3, 1 and 3 micrograms/kg/min for 30 min, all the three Ca-antagonists induced dose-dependent increases in mean arterial pressure (MAP) and pulse rate (PR), whereas nicardipine administered intravenously (i.v.) caused a decrease in MAP and an increase in PR.
Positive_regulation (increase) of PR associated with antagonist
17) Confidence 0.25 Published 1987 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 3576611 Disease Relevance 0.22 Pain Relevance 0.41
These results support the participation of the PR and the MAPK pathway in the facilitation of lordosis behavior by delta opioid receptors.
Positive_regulation (participation) of PR associated with delta opioid receptors and lordosis
18) Confidence 0.23 Published 2006 Journal Horm Behav Section Abstract Doc Link 16289112 Disease Relevance 0.17 Pain Relevance 0.31
We believe that 2.5 h is sufficient for the D1 agonist to induce Fos expression via ER dependent pathways, as vaginocervical stimulation is able to induce Fos expression via dopaminergic activation of PR [35] within 1h [36].
Positive_regulation (activation) of PR associated with agonist
19) Confidence 0.19 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2359852 Disease Relevance 0.09 Pain Relevance 0.18
Northern blot revealed that injection of E(2) resulted in expected changes, i.e., significant increases in PR mRNA in the POA, MBH and anterior pituitary, and in PPE mRNA in the MBH.
Positive_regulation (increases) of PR in POA
20) Confidence 0.14 Published 2001 Journal Neuroendocrinology Section Abstract Doc Link 11474214 Disease Relevance 0 Pain Relevance 0

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