INT37659

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Context Info
Confidence 0.06
First Reported 1987
Last Reported 1987
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.79
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3, F2) peptidase activity (F2) extracellular space (F2)
plasma membrane (F2)
Anatomy Link Frequency
cleavage 1
IGHG3 (Homo sapiens)
F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
peptic ulcer disease 2 78.20 Quite High
Disease Link Frequency Relevance Heat
Coagulation Disorder 6 94.56 High High
Disease 2 78.20 Quite High
Ulcers 2 77.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although immunoprecipitation between thrombin and the paraprotein could not be demonstrated, the patient's purified IgG, in the presence of thrombin, decreased the thrombin activity on a chromogenic substrate.
IgG Negative_regulation (decreased) of thrombin
1) Confidence 0.06 Published 1987 Journal Am. J. Hematol. Section Abstract Doc Link 3578266 Disease Relevance 0.37 Pain Relevance 0.07
In contrast to previously described paraproteins, this patient's IgG appeared to inhibit the activity of thrombin per se rather than to interfere with fibrinogen cleavage or fibrin polymerization.
IgG Negative_regulation (inhibit) of thrombin in cleavage
2) Confidence 0.04 Published 1987 Journal Am. J. Hematol. Section Abstract Doc Link 3578266 Disease Relevance 0.42 Pain Relevance 0.08

General Comments

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