INT3766

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Context Info
Confidence 0.69
First Reported 1977
Last Reported 2010
Negated 16
Speculated 4
Reported most in Abstract
Documents 192
Total Number 197
Disease Relevance 21.80
Pain Relevance 85.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
hippocampus 26
RVLM 18
frontal cortex 17
brain 12
XII 10
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 221 100.00 Very High Very High Very High
Somatostatin 117 100.00 Very High Very High Very High
Nucleus accumbens 66 100.00 Very High Very High Very High
gABA 22 100.00 Very High Very High Very High
antagonist 182 99.98 Very High Very High Very High
agonist 168 99.98 Very High Very High Very High
Morphine 154 99.98 Very High Very High Very High
Nicotine 47 99.98 Very High Very High Very High
Cannabinoid 12 99.98 Very High Very High Very High
Hippocampus 200 99.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pressure Volume 2 Under Development 3 99.98 Very High Very High Very High
Multiple System Atrophy 24 99.90 Very High Very High Very High
Urological Neuroanatomy 106 99.84 Very High Very High Very High
Anaerobic Bacterial Infections 2 99.84 Very High Very High Very High
INFLAMMATION 204 99.76 Very High Very High Very High
Overactive Bladder 8 99.56 Very High Very High Very High
Stress 21 99.28 Very High Very High Very High
Substance Withdrawal Syndrome 2 99.06 Very High Very High Very High
Ganglion Cysts 21 98.64 Very High Very High Very High
Porphyria 16 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Results indicate that Novelty, but not Formalin or Restraint, increases ACh release in the hippocampus and that the type of behavioral state displayed by the animal at the time of formalin injection determines the response of the septo-hippocampal cholinergic pathway.
Spec (determines) Positive_regulation (increases) of Localization (release) of ACh in hippocampus associated with hippocampus
1) Confidence 0.69 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067465 Disease Relevance 0.27 Pain Relevance 0.22
Ovariectomy caused the significant increase in both TTX-insensitive basal Ach release and TTX-insensitive stretch-induced Ach release.
Positive_regulation (increase) of Localization (release) of Ach
2) Confidence 0.69 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.14 Pain Relevance 0
The fenfluramine's ability to increase ACh release was potentiated by E(2) replacement with a 0.5 mg-pellet.
Positive_regulation (increase) of Localization (release) of ACh
3) Confidence 0.67 Published 2002 Journal Brain Res. Section Abstract Doc Link 12020863 Disease Relevance 0.39 Pain Relevance 0.23
Ch administration significantly increased ACh release (to 136% of basal values; P < 0.01) in the presence of the low neostigmine concentration, but failed to significantly increase ACh release following local electrical depolarization of striatal neurons.
Neg (failed) Positive_regulation (increase) of Localization (release) of ACh in neurons
4) Confidence 0.66 Published 1993 Journal Brain Res. Section Abstract Doc Link 8111630 Disease Relevance 0 Pain Relevance 0.19
The increase in XII ACh release caused by 10 microM morphine was blocked by the mu opioid antagonist naloxone and not blocked by the kappa opioid antagonist norbinaltorphimine.
Positive_regulation (increase) of Localization (release) of ACh in XII
5) Confidence 0.58 Published 2007 Journal Sleep Section Body Doc Link 17552371 Disease Relevance 0 Pain Relevance 0
MEASUREMENTS AND RESULTS: Morphine caused a statistically significant, concentration-dependent increase in XII ACh release.
Positive_regulation (increase) of Localization (release) of ACh in XII
6) Confidence 0.58 Published 2007 Journal Sleep Section Body Doc Link 17552371 Disease Relevance 0 Pain Relevance 0
Ovariectomy caused the significant increase in both TTX-insensitive basal Ach release and TTX-insensitive stretch-induced Ach release.
Positive_regulation (stretch-induced) of Localization (release) of Ach
7) Confidence 0.50 Published 2007 Journal Neurourol. Urodyn. Section Body Doc Link 17480029 Disease Relevance 0.14 Pain Relevance 0
Both basal and stimulated ACh release were found to be tetrodotoxin (TTX) sensitive.
Positive_regulation (stimulated) of Localization (release) of ACh associated with tetrodotoxin
8) Confidence 0.48 Published 1993 Journal Brain Res. Section Abstract Doc Link 8111630 Disease Relevance 0 Pain Relevance 0.19
During the later phase of abstinence, when no withdrawal symptoms were detectable, the opposite effect, i.e. an increase of ACh release was found.
Positive_regulation (increase) of Localization (release) of ACh associated with withdrawal
9) Confidence 0.47 Published 1999 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 10102787 Disease Relevance 0.19 Pain Relevance 0.97
On Day 2, ACh release increased in both sexes during the Formalin test.
Positive_regulation (increased) of Localization (release) of ACh
10) Confidence 0.47 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878722 Disease Relevance 0.22 Pain Relevance 0.29
In a separate experiment, ACh release in the NAC was monitored in 10-min intervals during free-feeding; ACh increased in the interval immediately following maximal food intake.
Positive_regulation (increased) of Localization (release) of ACh in NAC associated with nucleus accumbens
11) Confidence 0.47 Published 1992 Journal J. Neurochem. Section Abstract Doc Link 1573406 Disease Relevance 0 Pain Relevance 0.63
Peripheral administration of choline (Ch) chloride (30-120 mg/kg) to anesthetized animals caused dose-related (r = 0.994, P < 0.01) increases in ACh release; basal release rose from 117 +/- 7% to 141 +/- 5% of initial baseline levels (P < 0.05) and electrically evoked ACh release rose from 386 +/- 38% to 600 +/- 34% (P < 0.01) in rats given 120 mg/kg.
Positive_regulation (increases) of Localization (release) of ACh
12) Confidence 0.47 Published 1993 Journal Brain Res. Section Abstract Doc Link 8481795 Disease Relevance 0 Pain Relevance 0.44
Morphine at a low dose of 5 mg/kg (i.p.) increased ACh release by the RVLM by 42.4%.
Positive_regulation (increased) of Localization (release) of ACh in RVLM associated with rostral ventrolateral medulla and morphine
13) Confidence 0.47 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336550 Disease Relevance 0 Pain Relevance 1.08
The increased ACh release induced by local application of morphine was reversed by pretreatment with naloxone (1 mg/kg i.p.).
Positive_regulation (induced) of Localization (release) of ACh associated with narcan and morphine
14) Confidence 0.47 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336550 Disease Relevance 0 Pain Relevance 1.41
The increased ACh release induced by local application of morphine was reversed by pretreatment with naloxone (1 mg/kg i.p.).
Positive_regulation (increased) of Localization (release) of ACh associated with narcan and morphine
15) Confidence 0.47 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336550 Disease Relevance 0 Pain Relevance 1.41
Intraperitoneal (i.p.) administration of 5 and 10 mg/kg morphine significantly increased ACh release by the RVLM.
Positive_regulation (increased) of Localization (release) of ACh in RVLM associated with rostral ventrolateral medulla and morphine
16) Confidence 0.47 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14600399 Disease Relevance 0 Pain Relevance 0.88
The increased ACh release induced by local application of morphine was attenuated by pretreatment with yohimbine, but not prazosin.
Positive_regulation (increased) of Localization (release) of ACh associated with morphine
17) Confidence 0.47 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14600399 Disease Relevance 0 Pain Relevance 1.06
The increased ACh release induced by local application of morphine was attenuated by pretreatment with yohimbine, but not prazosin.
Positive_regulation (induced) of Localization (release) of ACh associated with morphine
18) Confidence 0.47 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14600399 Disease Relevance 0 Pain Relevance 1.06
TTX injected in the caudal ventrolateral medulla (CVLM) inhibited the phenylephrine-induced increase of ACh release.
Positive_regulation (increase) of Localization (release) of ACh in medulla associated with medulla and tetrodotoxin
19) Confidence 0.46 Published 1998 Journal Clin. Exp. Hypertens. Section Abstract Doc Link 9533616 Disease Relevance 0.08 Pain Relevance 0.94
The sevoflurane-induced ACh release was inhibited by 1,2-bis (2-aminophenoxy) ethane-N,N,N',N'-tetra-acetic acid (BAPTA-AM), suggesting the involvement of intracellular calcium-sensitive stores in the process.
Positive_regulation (induced) of Localization (release) of ACh
20) Confidence 0.46 Published 2005 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 16133935 Disease Relevance 0 Pain Relevance 0.14

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