INT37661

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Context Info
Confidence 0.59
First Reported 1987
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 38.60
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINC1) extracellular region (SERPINC1) plasma membrane (SERPINC1)
Anatomy Link Frequency
leucocyte 2
thrombocytes 2
plasma 1
liver 1
platelet 1
SERPINC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 2 100.00 Very High Very High Very High
cINOD 7 99.94 Very High Very High Very High
cva 818 99.92 Very High Very High Very High
Inflammation 316 99.84 Very High Very High Very High
Pain 15 99.38 Very High Very High Very High
antagonist 11 99.00 Very High Very High Very High
abdominal pain 15 97.52 Very High Very High Very High
anesthesia 34 96.88 Very High Very High Very High
Angina 3 95.08 Very High Very High Very High
cytokine 68 93.32 High High
Disease Link Frequency Relevance Heat
Depression 2 100.00 Very High Very High Very High
Thrombophilia 1595 99.96 Very High Very High Very High
Thrombosis 927 99.92 Very High Very High Very High
Disseminated Intravascular Coagulation 494 99.90 Very High Very High Very High
INFLAMMATION 317 99.84 Very High Very High Very High
Disorder Of Lipid Metabolism 19 99.84 Very High Very High Very High
Inborn Genetic Diseases 4 99.76 Very High Very High Very High
Injury 365 99.64 Very High Very High Very High
Burns 64 99.50 Very High Very High Very High
Thrombosis Related Under Development 634 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 30-year-old man with congenital antithrombin III deficiency was scheduled for artificial head replacement of the hip joint under general anesthesia.
Negative_regulation (deficiency) of antithrombin III in hip joint associated with anesthesia
1) Confidence 0.59 Published 2001 Journal Masui Section Abstract Doc Link 11452476 Disease Relevance 0.26 Pain Relevance 0.12
We report successful treatment of a 39-year-old man who suffered from right lower extremity arterial thrombosis associated with decreased levels of serum antithrombin III.
Negative_regulation (decreased) of antithrombin III in extremity associated with thrombosis
2) Confidence 0.58 Published 2000 Journal Surg. Today Section Abstract Doc Link 10930236 Disease Relevance 1.00 Pain Relevance 0.14
A diagnosis of DIC is made after taking into consideration the triggering disease, clinical picture, and unambiguous and striking hemostatic findings such as a drop in thrombocytes, loss of antithrombin activity, increased concentrations of D-dimers or fibrin monomers [7].
Negative_regulation (loss) of antithrombin in thrombocytes associated with disseminated intravascular coagulation and disease
3) Confidence 0.48 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 1.00 Pain Relevance 0
In these studies the duration of DIC was significantly shortened and organ functions were improved, but no significant reduction in mortality in the antithrombin groups was achieved.
Neg (no) Negative_regulation (reduction) of antithrombin associated with disseminated intravascular coagulation
4) Confidence 0.48 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 1.21 Pain Relevance 0
Congenital antithrombin III (ATIII) deficiency is a hereditary disease that predisposes to thromboembolic complications.
Negative_regulation (deficiency) of ATIII associated with inborn genetic diseases and cva
5) Confidence 0.43 Published 2009 Journal Masui Section Abstract Doc Link 20055199 Disease Relevance 0.51 Pain Relevance 0.05
We report perioperative management for twice in a patient with congenital ATIII deficiency.
Negative_regulation (deficiency) of ATIII
6) Confidence 0.43 Published 2009 Journal Masui Section Abstract Doc Link 20055199 Disease Relevance 0.54 Pain Relevance 0.11
Congenital antithrombin III (ATIII) deficiency is a hereditary disease that predisposes to thromboembolic complications.
Negative_regulation (deficiency) of antithrombin III associated with inborn genetic diseases and cva
7) Confidence 0.43 Published 2009 Journal Masui Section Abstract Doc Link 20055199 Disease Relevance 0.51 Pain Relevance 0.05
A 69-year-old man with congenital ATIII deficiency, with history of deep vein thrombosis (DVT) in his left popliteal vein, was scheduled for transurethral resection of bladder tumor (TUR-Bt).
Negative_regulation (deficiency) of ATIII in popliteal vein associated with bladder cancer and thrombosis
8) Confidence 0.43 Published 2009 Journal Masui Section Abstract Doc Link 20055199 Disease Relevance 0.56 Pain Relevance 0.11
Both the patient and his son were given the diagnosis of congenital ATIII deficiency.
Negative_regulation (deficiency) of ATIII
9) Confidence 0.43 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 9341285 Disease Relevance 0.40 Pain Relevance 0.16
The clinical manifestations of members of 28 families with congenital ATIII deficiency reported in Japan were reviewed.
Negative_regulation (deficiency) of ATIII
10) Confidence 0.43 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 9341285 Disease Relevance 0.32 Pain Relevance 0.13
[Congenital antithrombin III deficiency associated with pulmonary thromboembolism].
Negative_regulation (deficiency) of antithrombin III associated with pulmonary embolism and cva
11) Confidence 0.43 Published 1997 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Title Doc Link 9341285 Disease Relevance 0.46 Pain Relevance 0.18
Blood chemistry subsequently revealed an antithrombin III deficiency, which was confirmed to be inherent, after screening his family.
Negative_regulation (deficiency) of antithrombin III in Blood
12) Confidence 0.43 Published 2007 Journal Surg. Today Section Abstract Doc Link 17387563 Disease Relevance 0.63 Pain Relevance 0.16
Acute arterial thrombosis with antithrombin III deficiency in nephrotic syndrome: report of a case.
Negative_regulation (deficiency) of antithrombin III associated with pain, disorder of lipid metabolism and thrombosis
13) Confidence 0.42 Published 2000 Journal Surg. Today Section Title Doc Link 10930236 Disease Relevance 1.02 Pain Relevance 0.22
Antithrombin is a vitamin K independent glycoprotein and an essential inhibitor of thrombin and other serine proteases such as factors Xa and IXa [1].
Negative_regulation (inhibitor) of Antithrombin
14) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.45 Pain Relevance 0
Furthermore, biologically, the effect of antithrombin may be modified directly by bacterial endotoxins because porins (nonspecific channels of the bacterial outer membrane that allow transmembrane passage of nutrient molecules that are usually small and hydrophilic) not only enhanced thrombin activity but also inhibited the enhanced antithrombin activity resulting from antithrombin administration [74].
Negative_regulation (inhibited) of antithrombin
15) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.47 Pain Relevance 0.06
In sepsis, laboratory data demonstrate not only changes in the number of leucocytes but also a reduction in the number of thrombocytes and antithrombin concentration.


Negative_regulation (reduction) of antithrombin in thrombocytes associated with sepsis
16) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 1.13 Pain Relevance 0.10
Acquired antithrombin deficiency is more frequent than congenital deficiency and develops primarily through increased consumption or loss of antithrombin.
Negative_regulation (loss) of antithrombin
17) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.63 Pain Relevance 0
With reagents such as heparinase or natrium chlorate that degrade heparin sulfate, the effect of antithrombin on leucocyte migration could be abolished [36-38,43].
Negative_regulation (abolished) of antithrombin in leucocyte
18) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.38 Pain Relevance 0.07
Infusions of antithrombin significantly reduced mortality in monkeys previously treated intravenously with lethal doses of Escherichia coli.
Negative_regulation (reduced) of antithrombin
19) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.41 Pain Relevance 0.12
Disseminated intravascular coagulation and antithrombin-dependent inhibition of inflammation
Negative_regulation (inhibition) of antithrombin-dependent associated with inflammation and disseminated intravascular coagulation
20) Confidence 0.35 Published 2006 Journal Crit Care Section Body Doc Link PMC1550851 Disease Relevance 0.93 Pain Relevance 0.10

General Comments

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