INT37679

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Context Info
Confidence 0.34
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 11.93
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4)
endoplasmic reticulum (HLA-DRB4) plasma membrane (HLA-DRB4)
Anatomy Link Frequency
microglia 1
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal inflammation 3 97.44 Very High Very High Very High
cytokine 55 96.72 Very High Very High Very High
psoriasis 1 96.20 Very High Very High Very High
Inflammatory mediators 18 94.80 High High
Inflammation 127 86.00 High High
qutenza 5 83.60 Quite High
rheumatoid arthritis 4 76.88 Quite High
cINOD 21 73.28 Quite High
Inflammatory response 30 68.52 Quite High
antagonist 1 65.68 Quite High
Disease Link Frequency Relevance Heat
Death 81 100.00 Very High Very High Very High
Pancreatitis 17 99.68 Very High Very High Very High
Cancer 144 99.56 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 295 99.42 Very High Very High Very High
Necrosis 16 99.32 Very High Very High Very High
Disease 179 98.28 Very High Very High Very High
Apoptosis 164 98.20 Very High Very High Very High
Low Back Pain 3 97.44 Very High Very High Very High
Pemphigoid 15 96.80 Very High Very High Very High
Reprotox - General 1 3 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given that sulindac sulfide activated caspase-8 and increased membrane death receptor (DR4 and DR5) protein levels, we evaluated its combination with the endogenous death receptor ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).
Positive_regulation (increased) of DR4 associated with necrosis, cancer, apoptosis and death
1) Confidence 0.34 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 16227396 Disease Relevance 1.39 Pain Relevance 0.12
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Neg (no) Positive_regulation (effect) of DR4 associated with necrosis and cancer
2) Confidence 0.33 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.69 Pain Relevance 0.07
Concomitantly, we observed DR4, Fas(CD95) and caspase 8 activation, suggesting that these compounds activate both the mitochondrial and death receptor pathways working together to induce apoptosis.
Positive_regulation (activation) of DR4 associated with apoptosis and death
3) Confidence 0.33 Published 2009 Journal Anticancer Res. Section Abstract Doc Link 19846903 Disease Relevance 0.89 Pain Relevance 0.30
The frequencies of HLA-DR4 and HLA-DRw53 were shown to be significantly increased in 231 VKH patients as compared with those in 289 healthy controls (Table 4).
Positive_regulation (increased) of HLA-DR4
4) Confidence 0.25 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2645903 Disease Relevance 0.29 Pain Relevance 0
Susceptibility to PF has been correlated with the presence of DR4, DR14 and DR1 alleles; however, in contrast to PV, no single DR4 or DR14 allele was shown to be associated with the disease.

┬Ľ In an immunogenetic study of patients with autoimmune pancreatitis, a significant increase in DR4 was found.

Positive_regulation (increase) of DR4 associated with pancreatitis, pemphigoid and disease
5) Confidence 0.17 Published 2006 Journal BMC Med Section Body Doc Link PMC1618394 Disease Relevance 1.10 Pain Relevance 0.07
Binding of TRAIL to the death inducing receptors DR4/DR5 results in the recruitment of the Fas ┬ľassociated death domain (FADD) to the receptors, which initiates binding of procaspase-8 and procaspase-9, and the formation of the death inducing signaling complex (DISC) [9].
Positive_regulation (inducing) of DR4 associated with death
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.54 Pain Relevance 0.03
Of special interest was the finding that the prevalence of HLA-DR4 was elevated to the same degree in both groups but that genetic markers for ankylosing spondylitis and for psoriasis (HLA-B27 and Cw6 respectively) were similar in both groups and not increased above control population levels.
Positive_regulation (elevated) of HLA-DR4 associated with psoriasis and spinal inflammation
7) Confidence 0.04 Published 1987 Journal Br. J. Rheumatol. Section Abstract Doc Link 3580712 Disease Relevance 1.14 Pain Relevance 0.22
Human microglia display an activated phenotype when they surround plaques [23] that includes upregulation of Human Leukocyte Antigen-DR (HLA-DR) [18].
Positive_regulation (upregulation) of Leukocyte Antigen-DR in microglia
8) Confidence 0.02 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2784760 Disease Relevance 1.13 Pain Relevance 0.17
Activation of pathways leading to increased mitochondrial ROS generation and related to cell death (apoptotic or not) may be elicited by TNF, mainly by acting on the TNF receptor TNFRI, but a significant role for ROS has also been described in the activation of Fas as well as other death receptors, such as DR-4 and DR-5 [107].
Positive_regulation (activation) of DR-4 associated with apoptosis and death
9) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.99 Pain Relevance 0.04
SNU668 cells with ectopic expression of NAG-1 showed markedly elevated subG1 population, induced death receptor-4 (DR-4) and DR-5, and revealed smaller active fragments of caspase-3.
Positive_regulation (induced) of DR-4 associated with death
10) Confidence 0.01 Published 2006 Journal Apoptosis Section Abstract Doc Link 16699947 Disease Relevance 0.59 Pain Relevance 0.13
The lentiviral vectors we used also contain the P140K version of the O6-methylguanine-DNA methyltransferase (MGMT) gene [17] to increase marking after transplantation.
Positive_regulation (increase) of transplantation
11) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.76 Pain Relevance 0
The MGMT cassette in the anti-HIV vectors provides a means to increase marking after transplantation.
Positive_regulation (increase) of transplantation associated with acquired immune deficiency syndrome or hiv infection
12) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2765621 Disease Relevance 0.41 Pain Relevance 0

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